Basic Information | |
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Species | Arabidopsis lyrata |
Cazyme ID | 323060 |
Family | GT47 |
Protein Properties | Length: 423 Molecular Weight: 49023.9 Isoelectric Point: 9.1419 |
Chromosome | Chromosome/Scaffold: 5 Start: 9457512 End: 9461098 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 84 | 373 | 0 |
KRFKVWSYREGEQPLVHDGPVNDIYGIEGQFIDELSNVIGGPSGRFRASRPEEAHAFFLPFSVANIVHYVYQPITSPADFNRARLHRIFNDYVDVVARKH PFWNQSNGADHFMVSCHDWAPDVADSKPEFFKDFMRGLCNANTTEGFRPNIDISIPEINIPKRKLKPPFMGQTPENRTILAFFAGRAHGYIREVLFTHWK GKDKDVQVYDHLTKGQNYHELIGHSKFCLCPSGYEVASPREVEAIYSGCVPVVISDNYSLPFNDVLDWSKFSVEIPVDKIPDIKKILQEI |
Full Sequence |
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Protein Sequence Length: 423 Download |
MSSLLDHTNA LQSSSSSLYS PPNTIKRRSN LEKREEELRK ARAEIRRAVR FKNYTSNEEV 60 TYIPTGQIYR NSFAFHQSHI EMMKRFKVWS YREGEQPLVH DGPVNDIYGI EGQFIDELSN 120 VIGGPSGRFR ASRPEEAHAF FLPFSVANIV HYVYQPITSP ADFNRARLHR IFNDYVDVVA 180 RKHPFWNQSN GADHFMVSCH DWAPDVADSK PEFFKDFMRG LCNANTTEGF RPNIDISIPE 240 INIPKRKLKP PFMGQTPENR TILAFFAGRA HGYIREVLFT HWKGKDKDVQ VYDHLTKGQN 300 YHELIGHSKF CLCPSGYEVA SPREVEAIYS GCVPVVISDN YSLPFNDVLD WSKFSVEIPV 360 DKIPDIKKIL QEIPHDKYIR MYQNVMKVRR HFVVNRPAQP FDVIHMILHS VWLRRLNIRL 420 PS* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 9.0e-59 | 82 | 356 | 294 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Sequence Alignments (This image is cropped. Click for full image.) |
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