Basic Information | |
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Species | Arabidopsis lyrata |
Cazyme ID | 325645 |
Family | GT47 |
Protein Properties | Length: 337 Molecular Weight: 39281.4 Isoelectric Point: 8.4222 |
Chromosome | Chromosome/Scaffold: 6 Start: 4457763 End: 4458865 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 2 | 285 | 0 |
EKRFKIWTYREGEAPLFHKGPLNNIYAIEGQFMDEIENGNSRYKAASPEEATVFYIPVGIVNIIRFVYRPYTSYARDRLQNIVKDYISLISNRYPYWNRS RGADHFFLSCHDWAPDVSAVDPELYRHFIRALCNANASEGFTPMRDVSLPEINIPHSQLGFVHTGEAPQNRKLLAFFAGGSHGEVRKILFEQWKEKDKDV LVYEYLPKTMNYTKMMDKAKFCLCPSGWEVASPRIVESLYSGCVPVIIADSYVLPFSDVLNWKTFSVHIPISKMPDIKKILEAI |
Full Sequence |
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Protein Sequence Length: 337 Download |
MEKRFKIWTY REGEAPLFHK GPLNNIYAIE GQFMDEIENG NSRYKAASPE EATVFYIPVG 60 IVNIIRFVYR PYTSYARDRL QNIVKDYISL ISNRYPYWNR SRGADHFFLS CHDWAPDVSA 120 VDPELYRHFI RALCNANASE GFTPMRDVSL PEINIPHSQL GFVHTGEAPQ NRKLLAFFAG 180 GSHGEVRKIL FEQWKEKDKD VLVYEYLPKT MNYTKMMDKA KFCLCPSGWE VASPRIVESL 240 YSGCVPVIIA DSYVLPFSDV LNWKTFSVHI PISKMPDIKK ILEAISEEEY LEMQRRVLEV 300 RKHFVINRPS KPYDMLHMIM HSIWLRRLNV RIPLSE* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 2.0e-69 | 1 | 285 | 303 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Sequence Alignments (This image is cropped. Click for full image.) |
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