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Basic Information | |
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Species | Arabidopsis lyrata |
Cazyme ID | 350042 |
Family | GH79 |
Protein Properties | Length: 529 Molecular Weight: 58531 Isoelectric Point: 9.3542 |
Chromosome | Chromosome/Scaffold: 6 Start: 3056051 End: 3058374 |
Description | glucuronidase 2 |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 22 | 522 | 0 |
DENFVCATLDWWPHDKCNYDQCPWGYSSVINMDLTRPLLTKAIQAFKPLRIRIGGSLQDQVTYDVGNLKTPCRPFQKMNSGLFGFSKGCLHMKRWDELNS FLTATGAVVTFGLNALRGRHKLRGKAWGGAWDHINTQDFINYTVSKGYVIDSWEFGFLVLGIGNELSGSGVGASVSAELYGKDLIVLKDVINKVYKNSRL HKPILVAPGGFYEQQWYTKLLQISGPGVVDVVTHHIYNLGSGNDPALVKKIMDPSYLSQVSKTFKDVNQTIQEHGRWASPWVGESGGAYNSGGRHVSDTF IDSFWYLDQLGMSARHNTKVYCRQTLVGGFYGLLEKGTFVPNPDYYSALLWHRLMGKGVLAVQTDGPPQLRVYAHCSKGRAGVTLLLINLSNQSDFTVSV SNGIKVVLNAESRKKKSLLDTLKRPFSWIGSKASDGYLNREEYHLKPENGELQSKTMILNGKSLKPMATGDIPSLEPVLRGVNSPLNVLPLSMSFIVLPN F |
Full Sequence |
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Protein Sequence Length: 529 Download |
MAQETKRASI VVEGARRVCE TDENFVCATL DWWPHDKCNY DQCPWGYSSV INMDLTRPLL 60 TKAIQAFKPL RIRIGGSLQD QVTYDVGNLK TPCRPFQKMN SGLFGFSKGC LHMKRWDELN 120 SFLTATGAVV TFGLNALRGR HKLRGKAWGG AWDHINTQDF INYTVSKGYV IDSWEFGFLV 180 LGIGNELSGS GVGASVSAEL YGKDLIVLKD VINKVYKNSR LHKPILVAPG GFYEQQWYTK 240 LLQISGPGVV DVVTHHIYNL GSGNDPALVK KIMDPSYLSQ VSKTFKDVNQ TIQEHGRWAS 300 PWVGESGGAY NSGGRHVSDT FIDSFWYLDQ LGMSARHNTK VYCRQTLVGG FYGLLEKGTF 360 VPNPDYYSAL LWHRLMGKGV LAVQTDGPPQ LRVYAHCSKG RAGVTLLLIN LSNQSDFTVS 420 VSNGIKVVLN AESRKKKSLL DTLKRPFSWI GSKASDGYLN REEYHLKPEN GELQSKTMIL 480 NGKSLKPMAT GDIPSLEPVL RGVNSPLNVL PLSMSFIVLP NFDASACS* 540 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 6 | 332 | 327 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
DDBJ | BAB08480.1 | 0 | 6 | 528 | 2 | 516 | unnamed protein product [Arabidopsis thaliana] |
EMBL | CAB62595.1 | 0 | 1 | 528 | 1 | 521 | putative protein [Arabidopsis thaliana] |
RefSeq | NP_196400.2 | 0 | 1 | 528 | 23 | 543 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
RefSeq | NP_200933.2 | 0 | 6 | 528 | 25 | 539 | AtGUS1 (Arabidopsis thaliana glucuronidase 1); beta-glucuronidase |
RefSeq | XP_002514696.1 | 0 | 1 | 528 | 18 | 539 | Heparanase-2, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.005 | 250 | 441 | 235 | 431 | A Chain A, The Crystal Structure Of A Hyperthermoactive Exopolygalacturonase From Thermotoga Maritima |
PDB | 3vnz_A | 0.005 | 250 | 441 | 235 | 431 | A Chain A, The Crystal Structure Of A Hyperthermoactive Exopolygalacturonase From Thermotoga Maritima |
PDB | 3vny_A | 0.005 | 250 | 441 | 235 | 431 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
DK557248 | 252 | 279 | 529 | 0 |
HO797031 | 378 | 156 | 528 | 0 |
FD978266 | 225 | 246 | 469 | 0 |
EV125918 | 226 | 305 | 529 | 0 |
EE537753 | 218 | 212 | 429 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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