| Basic Information | |
|---|---|
| Species | Arabidopsis lyrata |
| Cazyme ID | 474511 |
| Family | GT68 |
| Protein Properties | Length: 564 Molecular Weight: 63978 Isoelectric Point: 7.5565 |
| Chromosome | Chromosome/Scaffold: 1 Start: 28767374 End: 28769767 |
| Description | O-fucosyltransferase family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT68 | 239 | 541 | 0 |
| KRVLVIPSHRFDYHYSRIIDIDRINTCLGRNVVVSFEEFWKKDKNRKKHHHVHINRFICYFSKPEPCYVDKEHITKLKALGITIGGKLDTPWEEDIASPS NKTAEEVETNFRSDDDLIAIGDVFYANVEREWVMQPGGPVAHKCRTLIEPNRLILLTAQRFIQTFLGKNYIALHFRRHGFLKFCNAKNPSCFYPIPQAAN CITRLIEKVEAPVIYLSTDAAESETGLLQSLLILNGKTVPLVKRPARDSAEKWDALLYRHGLEGDPQVEAMLDKTICAMSSVFVGASGSTFTEDILRLRK DWG | |||
| Full Sequence |
|---|
| Protein Sequence Length: 564 Download |
| MVKDSSSVSS SSSLSSPDEE SDLHNLLEES DSQIDQFRVS DAAAEQRPTF DVESLRSRLR 60 RNLKLNLTKK QSIVIFLPIV IILIYLSTDF SNYFSVRVPD SVFRSNTLTG RAHESDLQAL 120 YLLRKQESDL FSIWNHTLSN LSTIEDVKSA VFRQISLNRQ IQNALLSPHK TGNVEIGGSS 180 DVYFAGGSCR KVDQKLNGRK TIQWKPRPDK FLFAICLSGQ MSNHLICLEK HMFFAALLKR 240 VLVIPSHRFD YHYSRIIDID RINTCLGRNV VVSFEEFWKK DKNRKKHHHV HINRFICYFS 300 KPEPCYVDKE HITKLKALGI TIGGKLDTPW EEDIASPSNK TAEEVETNFR SDDDLIAIGD 360 VFYANVEREW VMQPGGPVAH KCRTLIEPNR LILLTAQRFI QTFLGKNYIA LHFRRHGFLK 420 FCNAKNPSCF YPIPQAANCI TRLIEKVEAP VIYLSTDAAE SETGLLQSLL ILNGKTVPLV 480 KRPARDSAEK WDALLYRHGL EGDPQVEAML DKTICAMSSV FVGASGSTFT EDILRLRKDW 540 GTASECDEYL CANEHPNFVA DPE* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| cd11296 | O-FucT_like | 0.0005 | 211 | 252 | 42 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| pfam10250 | O-FucT | 3.0e-5 | 234 | 530 | 323 | + GDP-fucose protein O-fucosyltransferase. This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. | ||
| cd11298 | O-FucT-2 | 2.0e-8 | 404 | 530 | 127 | + GDP-fucose protein O-fucosyltransferase 2. O-FucT-2 adds O-fucose to thrombospondin type 1 repeats (TSRs), and appears conserved in bilateria. The O-fucosylation of TSRs appears to play a role in regulating secretion of metalloproteases of the ADAMTS superfamily. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| cd11296 | O-FucT_like | 2.0e-18 | 378 | 537 | 170 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| DDBJ | BAF00786.1 | 0 | 1 | 563 | 1 | 563 | hypothetical protein [Arabidopsis thaliana] |
| RefSeq | NP_173170.2 | 0 | 15 | 563 | 4 | 564 | unknown protein [Arabidopsis thaliana] |
| RefSeq | NP_175780.1 | 0 | 1 | 563 | 1 | 563 | unknown protein [Arabidopsis thaliana] |
| RefSeq | NP_199853.1 | 0 | 15 | 563 | 4 | 566 | unknown protein [Arabidopsis thaliana] |
| RefSeq | XP_002264087.1 | 0 | 16 | 563 | 5 | 559 | PREDICTED: hypothetical protein [Vitis vinifera] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 4ap6_D | 0.004 | 404 | 530 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
| PDB | 4ap6_C | 0.004 | 404 | 530 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
| PDB | 4ap6_B | 0.004 | 404 | 530 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
| PDB | 4ap6_A | 0.004 | 404 | 530 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
| PDB | 4ap5_B | 0.004 | 404 | 530 | 263 | 369 | A Chain A, Crystal Structure Of Human Pofut2 |
