Basic Information | |
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Species | Arabidopsis lyrata |
Cazyme ID | 482474 |
Family | GT47 |
Protein Properties | Length: 447 Molecular Weight: 50922.4 Isoelectric Point: 9.4472 |
Chromosome | Chromosome/Scaffold: 4 Start: 16666733 End: 16668871 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 58 | 370 | 0 |
KVRVYMYNLPKRFTYGLIDQHSIARGGIKKPVDDVTTLKYPGHQHMHEWYLFSDLNRPEVDRSGSPIVRVLDPDDADLFYVPVFSSLSLIVNAGRPVEPG SGYSDEKMQEGLMEWLEGQEWWRRNGGRDHVIPAGDPNALYRILDRVKNSVLLVADFGRLRHDQGSFVKDVVIPYSHRVNLFNGEIGVQDRNTLLFFMGN RYRKDGGKVRDLLFQVLEKEDDVTIKHGTQSRENRRAATKGMHTSKFCLNPAGDTPSACRLFDSIVSLCVPVIVSDSIELPFEDVIDYRKFSIFVEANAA LQPGFLVQMLRKI |
Full Sequence |
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Protein Sequence Length: 447 Download |
MARRSSLLKR AAIAVVSVIA IYVILNASVS RSLPSSSDLP RQLIREDDDE GRAPIQPKVR 60 VYMYNLPKRF TYGLIDQHSI ARGGIKKPVD DVTTLKYPGH QHMHEWYLFS DLNRPEVDRS 120 GSPIVRVLDP DDADLFYVPV FSSLSLIVNA GRPVEPGSGY SDEKMQEGLM EWLEGQEWWR 180 RNGGRDHVIP AGDPNALYRI LDRVKNSVLL VADFGRLRHD QGSFVKDVVI PYSHRVNLFN 240 GEIGVQDRNT LLFFMGNRYR KDGGKVRDLL FQVLEKEDDV TIKHGTQSRE NRRAATKGMH 300 TSKFCLNPAG DTPSACRLFD SIVSLCVPVI VSDSIELPFE DVIDYRKFSI FVEANAALQP 360 GFLVQMLRKI KTKKILEYQR EMQPVRRYFD YDNPNGAVKE IWRQVSQKLP LIKLMSNRDR 420 RLVLRNLTEP NCSCLCTNQT GRITSI* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 1.0e-81 | 55 | 370 | 327 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |