Basic Information | |
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Species | Arabidopsis lyrata |
Cazyme ID | 489382 |
Family | GT47 |
Protein Properties | Length: 335 Molecular Weight: 39167 Isoelectric Point: 8.3303 |
Chromosome | Chromosome/Scaffold: 6 Start: 11319855 End: 11321101 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 2 | 286 | 0 |
EKRFKVYVYEEGEPPLVHDGPCKSVYAVEGRFITEIEKMRTKFRTYDANQAYVYFLPFSVTWLVRYLYEGNSDAKPLRTFVSDYIRLVSTNHPFWNRTNG ADHFMLACHDWGPLTSQADNDLFNTSIRVMCNANSSEGFNPSKDVTLPEIKLYGGEVDPKLRLSKTLSASPRPYLGFFAGGVHGPVRPILLNHWKQRDPD MPVYEYLPKHLNYYDFMRSSKFCFCPSGYEVASPRVIEAIYSECIPVILSVNFVLPFTDVLRWETFSVLVDVSEIPRLKEILMSI |
Full Sequence |
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Protein Sequence Length: 335 Download |
MEKRFKVYVY EEGEPPLVHD GPCKSVYAVE GRFITEIEKM RTKFRTYDAN QAYVYFLPFS 60 VTWLVRYLYE GNSDAKPLRT FVSDYIRLVS TNHPFWNRTN GADHFMLACH DWGPLTSQAD 120 NDLFNTSIRV MCNANSSEGF NPSKDVTLPE IKLYGGEVDP KLRLSKTLSA SPRPYLGFFA 180 GGVHGPVRPI LLNHWKQRDP DMPVYEYLPK HLNYYDFMRS SKFCFCPSGY EVASPRVIEA 240 IYSECIPVIL SVNFVLPFTD VLRWETFSVL VDVSEIPRLK EILMSISDEK YEWLKRNLRY 300 VRRHFELNDP PKRFDAFHLT LHSIWLRRLN LRLT* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 1.0e-61 | 1 | 286 | 307 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Sequence Alignments (This image is cropped. Click for full image.) |
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