Basic Information | |
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Species | Arabidopsis lyrata |
Cazyme ID | 490811 |
Family | GT47 |
Protein Properties | Length: 429 Molecular Weight: 49016 Isoelectric Point: 8.5854 |
Chromosome | Chromosome/Scaffold: 7 Start: 963654 End: 965742 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 104 | 381 | 0 |
EKRFKVYIYPDGDPNTFYQTPRKVTGKYASEGYFFQNIRESRFRTLDPEEADLFFIPISCHKMRGKGTSYENMTVIVQNYVDGLIAKYPYWNRTLGADHF FVTCHDVGVRAFEGSLLLIKNTIRVVCSPSYNVGFIPHKDVALPQVLQPFALPAGGNDVENRTTLGFWAGHRNSKIRVILARVWENDTELDISNNRINRA TGHLVYQKRFYRTKFCICPGGSQVNSARITDSIHYGCIPVILSDYYDLPFNDILNWRKFAVVLREQDVYNLKQILKNI |
Full Sequence |
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Protein Sequence Length: 429 Download |
MTIVKPSQFS FSGGGSSSLC SLKGSLLTVA ILTFGSLFYL SLNSMRTSPP SPVIVVTPIH 60 VPQTFVNEDK TDNDDGAAPT TEAETYSDVY HSPEAFRLNY AEMEKRFKVY IYPDGDPNTF 120 YQTPRKVTGK YASEGYFFQN IRESRFRTLD PEEADLFFIP ISCHKMRGKG TSYENMTVIV 180 QNYVDGLIAK YPYWNRTLGA DHFFVTCHDV GVRAFEGSLL LIKNTIRVVC SPSYNVGFIP 240 HKDVALPQVL QPFALPAGGN DVENRTTLGF WAGHRNSKIR VILARVWEND TELDISNNRI 300 NRATGHLVYQ KRFYRTKFCI CPGGSQVNSA RITDSIHYGC IPVILSDYYD LPFNDILNWR 360 KFAVVLREQD VYNLKQILKN IPHSEFISLH NNLVKVQKHF QWNSPPVKFD AFHMIMYELW 420 LRHHVIKY* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 4.0e-60 | 103 | 381 | 298 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Sequence Alignments (This image is cropped. Click for full image.) |
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