| Basic Information | |
|---|---|
| Species | Arabidopsis lyrata |
| Cazyme ID | 493582 |
| Family | GH79 |
| Protein Properties | Length: 537 Molecular Weight: 59781.1 Isoelectric Point: 7.8464 |
| Chromosome | Chromosome/Scaffold: 7 Start: 17927926 End: 17930728 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GH79 | 45 | 529 | 0 |
| DEDFICATLDWWPPEKCDYGTCSWDHASILNLDLNNTILQNAIKAFAPLKIRIGGTLQDIVIYETPDQKQPCLPFTKNSSILFGYTQGCLPMRRWDELNA FFRKTGARVIFGLNALSGRSIKPNGEAIGAWDYTNAESFIRFTAQNNHTIDGWELGNELCGSGVGARVAANQYAIDTINLRNIVNRVYKNVSPMPLVIGP GGFFEADWFTDYLNKAENSLNATTRHIYDLGPGVDEHLIEKILNPSYLDQEAITFRSVKNIIKKSSTKAVAWVGESGGAYNSGRNLVSNAFVYSFWYLDQ LGMASLYDTKTYCRQSLIGGNYGLLNTTNFTPNPDYYSALIWRQLMGRKALFTTFSGTKKIRSYTHCARQSKGITVLLMNLDNTTTVVAKVELNKTFSLR HTKHMKSYKRATSQLPQDPNGEIQREEYHLTAKDGNLHSQTMLLNGNALQVNSTGDLPPIEPIHINSTEPITIAPYSIVFVHMRS | |||
| Full Sequence |
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| Protein Sequence Length: 537 Download |
| MGCRQIWIIV LFLCVFQFLD CTVSSAVEET GTVSVYGRAA VGTIDEDFIC ATLDWWPPEK 60 CDYGTCSWDH ASILNLDLNN TILQNAIKAF APLKIRIGGT LQDIVIYETP DQKQPCLPFT 120 KNSSILFGYT QGCLPMRRWD ELNAFFRKTG ARVIFGLNAL SGRSIKPNGE AIGAWDYTNA 180 ESFIRFTAQN NHTIDGWELG NELCGSGVGA RVAANQYAID TINLRNIVNR VYKNVSPMPL 240 VIGPGGFFEA DWFTDYLNKA ENSLNATTRH IYDLGPGVDE HLIEKILNPS YLDQEAITFR 300 SVKNIIKKSS TKAVAWVGES GGAYNSGRNL VSNAFVYSFW YLDQLGMASL YDTKTYCRQS 360 LIGGNYGLLN TTNFTPNPDY YSALIWRQLM GRKALFTTFS GTKKIRSYTH CARQSKGITV 420 LLMNLDNTTT VVAKVELNKT FSLRHTKHMK SYKRATSQLP QDPNGEIQRE EYHLTAKDGN 480 LHSQTMLLNG NALQVNSTGD LPPIEPIHIN STEPITIAPY SIVFVHMRSV VVPACA* 540 |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 28 | 346 | 320 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| DDBJ | BAB10787.1 | 0 | 1 | 536 | 1 | 536 | unnamed protein product [Arabidopsis thaliana] |
| EMBL | CBI25561.1 | 0 | 6 | 535 | 5 | 532 | unnamed protein product [Vitis vinifera] |
| RefSeq | NP_851092.1 | 0 | 136 | 536 | 1 | 401 | AtGUS3 (Arabidopsis thaliana glucuronidase 3); beta-glucuronidase |
| RefSeq | NP_851093.1 | 0 | 1 | 536 | 1 | 536 | AtGUS3 (Arabidopsis thaliana glucuronidase 3); beta-glucuronidase |
| RefSeq | XP_002324603.1 | 0 | 31 | 536 | 1 | 506 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0000003 | 57 | 393 | 36 | 369 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| PDB | 3vnz_A | 0.0000003 | 57 | 393 | 36 | 369 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| PDB | 3vny_A | 0.0000003 | 57 | 393 | 36 | 369 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
