| Basic Information | |
|---|---|
| Species | Arabidopsis lyrata |
| Cazyme ID | 496280 |
| Family | GH79 |
| Protein Properties | Length: 538 Molecular Weight: 59502.9 Isoelectric Point: 7.5937 |
| Chromosome | Chromosome/Scaffold: 8 Start: 19932163 End: 19935421 |
| Description | glucuronidase 1 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 39 | 531 | 0 |
| DENFVCATLDWWPPEKCNYDQCPWGYASLINLNLSSPLLAKAIQAFRTLRIRIGGSLQDQVIYDVGDLKTPCTQFEKTDDGLFGFSKGCLYMKRWDELNR FFHATGAIVTFGLNALHGRDKLNGTAWGGDWDHTNTQDFMNYTVSKGYAIDSWELGNELSGSGIWASVSVELYGKDLILLKDVINNVYKNSRTKPLVVAP GGFFEEKWYSELLRLSGPGVLDVLTHHIYNLGPGNDPMLVNRILDPNYLSGISGTFANVNRTIQEHGPWAAAWVGEAGGAFNSGGRQVSETFINSFWYLD QLGISSKHNTKVYCRQALVGGFYGLLEKETFVPNPDYYSALLWHRLMGKGVLGVQTTASEYLRAYVHCSKRRAGITILLINLSKNTTFTVAVSNGVNVVL QADTMKRKSFLETLKSKVSWVGNKASDGYLNREEYHLSPKHGDLHSKIMLLNGNPLVPTATGDIPKLEPARHGVKSPVYINPLSISFIVLPTF | |||
| Full Sequence |
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| Protein Sequence Length: 538 Download |
| MGFKVVFLIS LFLLPVTFGS NMERTTLVID GAHGIAETDE NFVCATLDWW PPEKCNYDQC 60 PWGYASLINL NLSSPLLAKA IQAFRTLRIR IGGSLQDQVI YDVGDLKTPC TQFEKTDDGL 120 FGFSKGCLYM KRWDELNRFF HATGAIVTFG LNALHGRDKL NGTAWGGDWD HTNTQDFMNY 180 TVSKGYAIDS WELGNELSGS GIWASVSVEL YGKDLILLKD VINNVYKNSR TKPLVVAPGG 240 FFEEKWYSEL LRLSGPGVLD VLTHHIYNLG PGNDPMLVNR ILDPNYLSGI SGTFANVNRT 300 IQEHGPWAAA WVGEAGGAFN SGGRQVSETF INSFWYLDQL GISSKHNTKV YCRQALVGGF 360 YGLLEKETFV PNPDYYSALL WHRLMGKGVL GVQTTASEYL RAYVHCSKRR AGITILLINL 420 SKNTTFTVAV SNGVNVVLQA DTMKRKSFLE TLKSKVSWVG NKASDGYLNR EEYHLSPKHG 480 DLHSKIMLLN GNPLVPTATG DIPKLEPARH GVKSPVYINP LSISFIVLPT FDAPACS* 540 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 22 | 341 | 320 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| DDBJ | BAB08480.1 | 0 | 22 | 537 | 1 | 516 | unnamed protein product [Arabidopsis thaliana] |
| EMBL | CAB62595.1 | 0 | 18 | 537 | 1 | 521 | putative protein [Arabidopsis thaliana] |
| RefSeq | NP_196400.2 | 0 | 1 | 537 | 1 | 543 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
| RefSeq | NP_200933.2 | 0 | 1 | 537 | 1 | 539 | AtGUS1 (Arabidopsis thaliana glucuronidase 1); beta-glucuronidase |
| RefSeq | XP_002514696.1 | 0 | 15 | 537 | 15 | 539 | Heparanase-2, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.009 | 51 | 440 | 36 | 423 | A Chain A, Crystal Structure Of The Polygalacturonase From Colletotrichum Lupini And Its Implications For The Interaction With Polygalacturonase- Inhibiting Proteins |
| PDB | 3vnz_A | 0.009 | 51 | 440 | 36 | 423 | A Chain A, Crystal Structure Of The Polygalacturonase From Colletotrichum Lupini And Its Implications For The Interaction With Polygalacturonase- Inhibiting Proteins |
| PDB | 3vny_A | 0.009 | 51 | 440 | 36 | 423 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
