| Basic Information | |
|---|---|
| Species | Arabidopsis lyrata |
| Cazyme ID | 497509 |
| Family | GH79 |
| Protein Properties | Length: 442 Molecular Weight: 49351.4 Isoelectric Point: 8.3783 |
| Chromosome | Chromosome/Scaffold: 665 Start: 18 End: 3400 |
| Description | glucuronidase 1 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 39 | 417 | 0 |
| DENFVCATLDWWPPEKCNYDQCPWGYASLINLNLSSPLLAKAFQAFRTLRIRIGASLQDQVIYDVGDLKTPCTQFEKTDDGLFGFYKGCLYMKRWDELNR FFHATGAIVTFGLDALHGRDKLNGTAWGGDWDHTNTQDFMTTQSQRLSGSGIWASVSVELDGKDLILLKDVINNVYKNSRTRPLVVAPGGFFEEKWYSEL LRLSGPGVLDVLTHHIYNLGPGNDPMLVNRILDPNYLSGISGTFANVNRTIQEHGPWAAAWVGEAGGAFNSGGRQVSETFINSFCSVFRRSITPKYTADK LWLEVSTVCSKRKRLFPIQITTGNALLWHRLMGKGVLGVQTTASEYLRAYVHCSKRRAGITILLINLSKNTTFTVAVSN | |||
| Full Sequence |
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| Protein Sequence Length: 442 Download |
| MGFKVVFLIS LFLLPVTFGS NMERTTLVID GGHGIAETDE NFVCATLDWW PPEKCNYDQC 60 PWGYASLINL NLSSPLLAKA FQAFRTLRIR IGASLQDQVI YDVGDLKTPC TQFEKTDDGL 120 FGFYKGCLYM KRWDELNRFF HATGAIVTFG LDALHGRDKL NGTAWGGDWD HTNTQDFMTT 180 QSQRLSGSGI WASVSVELDG KDLILLKDVI NNVYKNSRTR PLVVAPGGFF EEKWYSELLR 240 LSGPGVLDVL THHIYNLGPG NDPMLVNRIL DPNYLSGISG TFANVNRTIQ EHGPWAAAWV 300 GEAGGAFNSG GRQVSETFIN SFCSVFRRSI TPKYTADKLW LEVSTVCSKR KRLFPIQITT 360 GNALLWHRLM GKGVLGVQTT ASEYLRAYVH CSKRRAGITI LLINLSKNTT FTVAVSNGVN 420 VVLQADTMKR NLFWNTQEQG FL |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 7.0e-159 | 22 | 322 | 313 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| DDBJ | BAB08480.1 | 0 | 22 | 436 | 1 | 430 | unnamed protein product [Arabidopsis thaliana] |
| EMBL | CAB62595.1 | 0 | 18 | 441 | 1 | 440 | putative protein [Arabidopsis thaliana] |
| RefSeq | NP_196400.2 | 0 | 1 | 441 | 1 | 462 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
| RefSeq | NP_200933.2 | 0 | 1 | 436 | 1 | 453 | AtGUS1 (Arabidopsis thaliana glucuronidase 1); beta-glucuronidase |
| RefSeq | XP_002514696.1 | 0 | 15 | 424 | 15 | 439 | Heparanase-2, putative [Ricinus communis] |
