y
Basic Information | |
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Species | Medicago truncatula |
Cazyme ID | AC233660_42.1 |
Family | GH31 |
Protein Properties | Length: 592 Molecular Weight: 66055.5 Isoelectric Point: 6.1986 |
Chromosome | Chromosome/Scaffold: 2336602 Start: 171184 End: 172959 |
Description | alpha-xylosidase 1 |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH31 | 1 | 435 | 0 |
MDGHKDFTVNPVNYPLPKLLNFLDRIHSIGMKYIVINDPGIAVNTKYGVYQRGMANDVFIKYEGEPFMAMVWPGAVYFPDFLNPKTVSWWADEIRRFHEL VPIDGLWIDMNEVSNFCTGKCTIPKERFCPLQGEKLPNSTCCLDCTNITSTRWDDPPYKINASGNEIPIGYKTIATSAVHYNGVLEYDAHSLFGFSEAIA THKALSELQGKRPFVLSRSTYVGSGKYAAHWTGDNKGTWEDLRYTISTILNFGIFGMPMVGADICGFYPSFYPTLRYPISTEELCNRWIEVGAFYPFSRD HSSVISPRQELYQWESVAESARNALGMRYKLLPYLYTLNYEAHISGAPIARPLFFSFPTYIECYSLSTQFLLGSSLMISPVLEQGKTEVDALFPPGTWYS LFDLTQVIVSKDGTNVTLNAPLHVVNVHLYQNSIL |
Full Sequence |
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Protein Sequence Length: 592 Download |
MDGHKDFTVN PVNYPLPKLL NFLDRIHSIG MKYIVINDPG IAVNTKYGVY QRGMANDVFI 60 KYEGEPFMAM VWPGAVYFPD FLNPKTVSWW ADEIRRFHEL VPIDGLWIDM NEVSNFCTGK 120 CTIPKERFCP LQGEKLPNST CCLDCTNITS TRWDDPPYKI NASGNEIPIG YKTIATSAVH 180 YNGVLEYDAH SLFGFSEAIA THKALSELQG KRPFVLSRST YVGSGKYAAH WTGDNKGTWE 240 DLRYTISTIL NFGIFGMPMV GADICGFYPS FYPTLRYPIS TEELCNRWIE VGAFYPFSRD 300 HSSVISPRQE LYQWESVAES ARNALGMRYK LLPYLYTLNY EAHISGAPIA RPLFFSFPTY 360 IECYSLSTQF LLGSSLMISP VLEQGKTEVD ALFPPGTWYS LFDLTQVIVS KDGTNVTLNA 420 PLHVVNVHLY QNSILPMQQG GMISKDARMT PFSLIVTFPA GANEGEAKGN LFLDDDELPE 480 MKLGNGYSTY IDFHASVKEG TVKVWSQVQE GKFALDKGWV IDTINVLGLN GNGAIGTIEI 540 NGKPTNVKID TTKQNYIHGR GDGEKNIVMV GMKGLNIPVG KSFAMTWKMG S* 600 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam01055 | Glyco_hydro_31 | 3.0e-44 | 1 | 120 | 120 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. | ||
cd06602 | GH31_MGAM_SI_GAA | 1.0e-52 | 1 | 116 | 120 | + This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). | ||
cd06604 | GH31_glucosidase_II_MalA | 1.0e-91 | 1 | 346 | 352 | + Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized in Bacillus thermoamyloliquefaciens where it forms a homohexamer. This family also includes the MalA alpha-glucosidase from Sulfolobus sulfataricus and the AglA alpha-glucosidase from Picrophilus torridus. MalA is part of the carbohydrate-metabolizing machinery that allows this organism to utilize carbohydrates, such as maltose, as the sole carbon and energy source. | ||
cd06602 | GH31_MGAM_SI_GAA | 3.0e-93 | 187 | 364 | 179 | + This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). | ||
pfam01055 | Glyco_hydro_31 | 6.0e-108 | 179 | 435 | 260 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. |
Gene Ontology | |
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GO Term | Description |
GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
GO:0005975 | carbohydrate metabolic process |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | NP_177023.1 | 0 | 1 | 590 | 332 | 913 | XYL1 (ALPHA-XYLOSIDASE 1); alpha-N-arabinofuranosidase/ hydrolase, hydrolyzing O-glycosyl compounds / xylan 1,4-beta-xylosidase [Arabidopsis thaliana] |
RefSeq | XP_002282429.1 | 0 | 1 | 590 | 337 | 921 | PREDICTED: hypothetical protein isoform 1 [Vitis vinifera] |
RefSeq | XP_002311455.1 | 0 | 1 | 590 | 323 | 907 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002315944.1 | 0 | 1 | 590 | 341 | 925 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002531635.1 | 0 | 1 | 590 | 343 | 927 | alpha-glucosidase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3w38_A | 0 | 1 | 549 | 361 | 871 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
PDB | 3w37_A | 0 | 1 | 549 | 361 | 871 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
PDB | 3lpp_D | 0 | 1 | 587 | 359 | 898 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
PDB | 3lpp_C | 0 | 1 | 587 | 359 | 898 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
PDB | 3lpp_B | 0 | 1 | 587 | 359 | 898 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
HO795307 | 594 | 1 | 590 | 0 |
ES818715 | 397 | 92 | 487 | 0 |
ES819167 | 312 | 202 | 513 | 0 |
DY825555 | 308 | 137 | 444 | 0 |
DR926414 | 305 | 204 | 508 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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