| Basic Information | |
|---|---|
| Species | Arabidopsis thaliana |
| Cazyme ID | AT1G67410.1 |
| Family | GT47 |
| Protein Properties | Length: 431 Molecular Weight: 49755.9 Isoelectric Point: 7.1787 |
| Chromosome | Chromosome/Scaffold: 1 Start: 25251193 End: 25253667 |
| Description | exostosin family domain containing protein, expressed |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT47 | 51 | 361 | 0 |
| KPLRVFMYDLPRKFNIAMMDPHSSDVEPITGKNLPSWPQTSGIKRQHSVEYWLMASLLNGGEDENEAIRVFDPDLADVFYVPFFSSLSFNTHGKNMTDPD TEFDRLLQVELMEFLENSKYWNRSGGKDHVIPMTHPNAFRFLRQQVNASILIVVDFGRYSKDMARLSKDVVSPYVHVVESLNEEGDDGMGDPFEARTTLL YFRGNTVRKDEGKIRLRLEKLLAGNSDVHFEKSVATTQNIKVSTEGMRSSKFCLHPAGDTPSSCRLFDAIVSHCIPVIISDKIELPFEDEIDYSEFSLFF SIKESLEPGYI | |||
| Full Sequence |
|---|
| Protein Sequence Length: 431 Download |
| MYGKTICTIV FFIFLVASFS IYMGTVDPRP YFYLLQSQPN GASSPCSSSG KPLRVFMYDL 60 PRKFNIAMMD PHSSDVEPIT GKNLPSWPQT SGIKRQHSVE YWLMASLLNG GEDENEAIRV 120 FDPDLADVFY VPFFSSLSFN THGKNMTDPD TEFDRLLQVE LMEFLENSKY WNRSGGKDHV 180 IPMTHPNAFR FLRQQVNASI LIVVDFGRYS KDMARLSKDV VSPYVHVVES LNEEGDDGMG 240 DPFEARTTLL YFRGNTVRKD EGKIRLRLEK LLAGNSDVHF EKSVATTQNI KVSTEGMRSS 300 KFCLHPAGDT PSSCRLFDAI VSHCIPVIIS DKIELPFEDE IDYSEFSLFF SIKESLEPGY 360 ILNNLRQFPK EKWLEMWKRL KNVSHHFEFQ YPPKREDAVN MLWRQVKHKI PYVKLAVHRN 420 RRLKVPDWWL * 480 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 5.0e-83 | 49 | 368 | 327 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0003824 | catalytic activity |
| GO:0008150 | biological_process |
| GO:0012505 | endomembrane system |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | AAC18793.1 | 0 | 1 | 410 | 1 | 440 | End is cut off [Arabidopsis thaliana] |
| RefSeq | NP_176908.2 | 0 | 1 | 430 | 1 | 430 | exostosin family protein [Arabidopsis thaliana] |
| RefSeq | XP_002272591.1 | 0 | 27 | 429 | 27 | 426 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002456855.1 | 0 | 53 | 429 | 61 | 431 | hypothetical protein SORBIDRAFT_03g044100 [Sorghum bicolor] |
| RefSeq | XP_002512333.1 | 0 | 1 | 429 | 1 | 431 | catalytic, putative [Ricinus communis] |
