y
Basic Information | |
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Species | Arabidopsis thaliana |
Cazyme ID | AT1G72970.1 |
Family | AA3 |
Protein Properties | Length: 595 Molecular Weight: 65344.1 Isoelectric Point: 10.2517 |
Chromosome | Chromosome/Scaffold: 1 Start: 27452766 End: 27455964 |
Description | HOTHEAD precursor, putative, expressed |
View CDS |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
AA3 | 42 | 587 | 0 |
KASTFSSSSSSSFSSNGQDSSYDYIVIGGGTAGCPLAATLSQNFSVLVLERGGVPFTNANVSFLRNFHIGLADISASSASQAFVSTDGVYNARARVLGGG SCINAGFYSRADAAFVKRAGWDPKLVKESYPWVEREIVHQPKLTLWQKALRDSLLEVGVRPFNGFTYDHVSGTKIGGTIFDRFGRRHTAAELLAYANPQK LRVLIYATVQKIVFDTSGTRPRVTGVIFKDEKGNQHQALLSNRKGSEVILSSGAIGSPQMLMLSGIGPKKELQRLKIPVVLENEHVGKGMADNPMNTILV PSKAPIEQSLIQTVGITKMGVYVEASTGFGQSPESIHTHYGIMSNKNELFSTIPAKQRRPEATQAYITRNKYQLHEAFNGSFILEKLAYPISRGHLSLVN TNVDDNPSVTFNYFKHPVDLQRCVEAIRLVSKVVTSNRFLNYTQCDKQNVHKMLSLSVKANINLRPKQLNDTKSMAQFCKDTVVTIWHYHGGCLVGKVVS PNRKVLGVDRLRVIDGSTFDESPGTNPQATMMMMGRYMGVKILRER |
Full Sequence |
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Protein Sequence Length: 595 Download |
MALKLFLFAL LLCLPTSLSS TASKGKEKKS KFNPYRYTFI DKASTFSSSS SSSFSSNGQD 60 SSYDYIVIGG GTAGCPLAAT LSQNFSVLVL ERGGVPFTNA NVSFLRNFHI GLADISASSA 120 SQAFVSTDGV YNARARVLGG GSCINAGFYS RADAAFVKRA GWDPKLVKES YPWVEREIVH 180 QPKLTLWQKA LRDSLLEVGV RPFNGFTYDH VSGTKIGGTI FDRFGRRHTA AELLAYANPQ 240 KLRVLIYATV QKIVFDTSGT RPRVTGVIFK DEKGNQHQAL LSNRKGSEVI LSSGAIGSPQ 300 MLMLSGIGPK KELQRLKIPV VLENEHVGKG MADNPMNTIL VPSKAPIEQS LIQTVGITKM 360 GVYVEASTGF GQSPESIHTH YGIMSNKNEL FSTIPAKQRR PEATQAYITR NKYQLHEAFN 420 GSFILEKLAY PISRGHLSLV NTNVDDNPSV TFNYFKHPVD LQRCVEAIRL VSKVVTSNRF 480 LNYTQCDKQN VHKMLSLSVK ANINLRPKQL NDTKSMAQFC KDTVVTIWHY HGGCLVGKVV 540 SPNRKVLGVD RLRVIDGSTF DESPGTNPQA TMMMMGRYMG VKILRERLGN KAGV* 600 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
TIGR03970 | Rv0697 | 8.0e-21 | 64 | 335 | 314 | + dehydrogenase, Rv0697 family. This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function. | ||
pfam05199 | GMC_oxred_C | 3.0e-27 | 431 | 576 | 151 | + GMC oxidoreductase. This domain found associated with pfam00732. | ||
TIGR01810 | betA | 3.0e-38 | 64 | 576 | 565 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
COG2303 | BetA | 4.0e-46 | 59 | 587 | 580 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
PLN02785 | PLN02785 | 0 | 26 | 594 | 569 | + Protein HOTHEAD |
Gene Ontology | |
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GO Term | Description |
GO:0005576 | extracellular region |
GO:0007267 | cell-cell signaling |
GO:0009553 | embryo sac development |
GO:0010430 | fatty acid omega-oxidation |
GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
DDBJ | BAA77842.1 | 0 | 15 | 594 | 15 | 594 | ACE [Arabidopsis thaliana] |
RefSeq | NP_001154469.1 | 0 | 15 | 594 | 15 | 567 | HTH (HOTHEAD); FAD binding / aldehyde-lyase/ mandelonitrile lyase [Arabidopsis thaliana] |
RefSeq | NP_565050.1 | 0 | 15 | 594 | 15 | 594 | HTH (HOTHEAD); FAD binding / aldehyde-lyase/ mandelonitrile lyase [Arabidopsis thaliana] |
RefSeq | XP_002329018.1 | 0 | 32 | 594 | 29 | 591 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002527404.1 | 0 | 34 | 593 | 38 | 596 | glucose-methanol-choline (gmc) oxidoreductase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3gdp_B | 0 | 60 | 587 | 24 | 517 | A Chain A, Rhamnogalacturonan Lyase From Aspergillus Aculeatus |
PDB | 3gdp_A | 0 | 60 | 587 | 24 | 517 | A Chain A, Rhamnogalacturonan Lyase From Aspergillus Aculeatus |
PDB | 3gdn_B | 0 | 60 | 587 | 24 | 517 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
PDB | 3gdn_A | 0 | 60 | 587 | 24 | 517 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
PDB | 1ju2_B | 0 | 60 | 587 | 24 | 517 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
Metabolic Pathways | |||
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Pathway Name | Reaction | EC | Protein Name |
amygdalin and prunasin degradation | MANDELONITRILE-LYASE-RXN | EC-4.1.2.10 | mandelonitrile lyase |
cutin biosynthesis | RXN-2121 | EC-1.1.1 | ω-hydroxy fatty acid ω-alcohol dehydrogenase |
cutin biosynthesis | RXN-9802 | EC-1.1.1 | ω-hydroxy fatty acid ω-alcohol dehydrogenase |
suberin biosynthesis | RXN-2121 | EC-1.1.1 | ω-hydroxy fatty acid ω-alcohol dehydrogenase |
vicianin bioactivation | MANDELONITRILE-LYASE-RXN | EC-4.1.2.10 | mandelonitrile lyase |