| Basic Information | |
|---|---|
| Species | Arabidopsis thaliana |
| Cazyme ID | AT1G74680.1 |
| Family | GT47 |
| Protein Properties | Length: 462 Molecular Weight: 52659 Isoelectric Point: 9.1524 |
| Chromosome | Chromosome/Scaffold: 1 Start: 28059188 End: 28061119 |
| Description | exostosin family domain containing protein, expressed |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GT47 | 74 | 394 | 0 |
| VLKVFMYDLPSEFHFGILNWHKKGSEIWPNVNNISTIPSYPGGLNRQHSVEYWLTLDLLASETPEIKRPCSSAAIRVKNSNEADIVFVPFFASLSYNRKS KLRGNETSSDDRLLQERLVEFLKSQDEWKRFDGKDHLIVAHHPNSLLYARNFLGSAMFVLSDFGRYSSAIANLEKDIIAPYVHVVKTISNNESASFEKRP VLAYFQGAIYRKDGGTIRQELYNLLKDEKDVHFAFGTVRGNGTKQTGKGMASSKFCLNIAGDTPSSNRLFDAIVSHCVPVIISDQIELPFEDTLDYSGFS VFVHASEAVKKEFLVNILRGI | |||
| Full Sequence |
|---|
| Protein Sequence Length: 462 Download |
| MIKMSEKSLL SSKFLFYTIT VSTLLFIVSS LVFLQRHDSS FTSSLVRKLI LPRTDIKNEE 60 FGLIDTKCDR DRDVLKVFMY DLPSEFHFGI LNWHKKGSEI WPNVNNISTI PSYPGGLNRQ 120 HSVEYWLTLD LLASETPEIK RPCSSAAIRV KNSNEADIVF VPFFASLSYN RKSKLRGNET 180 SSDDRLLQER LVEFLKSQDE WKRFDGKDHL IVAHHPNSLL YARNFLGSAM FVLSDFGRYS 240 SAIANLEKDI IAPYVHVVKT ISNNESASFE KRPVLAYFQG AIYRKDGGTI RQELYNLLKD 300 EKDVHFAFGT VRGNGTKQTG KGMASSKFCL NIAGDTPSSN RLFDAIVSHC VPVIISDQIE 360 LPFEDTLDYS GFSVFVHASE AVKKEFLVNI LRGITEDQWK KKWGRLKEVA GCFEYRFPSQ 420 VGDSVNMIWS AVSHKLSSLQ FDVHRKNRYR RSEMFDRNGS S* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 4.0e-60 | 75 | 394 | 330 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0003824 | catalytic activity |
| GO:0008150 | biological_process |
| GO:0012505 | endomembrane system |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | AAD55303.1 | 0 | 4 | 461 | 1 | 458 | AC008263_34 F25A4.34 [Arabidopsis thaliana] |
| RefSeq | NP_565089.1 | 0 | 1 | 461 | 1 | 461 | exostosin family protein [Arabidopsis thaliana] |
| RefSeq | XP_002284930.1 | 0 | 4 | 455 | 1 | 451 | PREDICTED: hypothetical protein isoform 1 [Vitis vinifera] |
| RefSeq | XP_002284932.1 | 0 | 68 | 455 | 27 | 412 | PREDICTED: hypothetical protein isoform 2 [Vitis vinifera] |
| RefSeq | XP_002514760.1 | 0 | 64 | 454 | 101 | 489 | catalytic, putative [Ricinus communis] |
