| Basic Information | |
|---|---|
| Species | Arabidopsis thaliana |
| Cazyme ID | AT2G28110.1 |
| Family | GT47 |
| Protein Properties | Length: 449 Molecular Weight: 51694.2 Isoelectric Point: 9.517 |
| Chromosome | Chromosome/Scaffold: 2 Start: 11977944 End: 11979837 |
| Description | exostosin family domain containing protein, expressed |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT47 | 93 | 393 | 0 |
| NLKIYVYDLPSKFNKDWLANDRCTNHLFAAEVALHKAFLSLEGDVRTEDPYEADFFFVPVYVSCNFSTINGFPAIGHARSLINDAIKLVSTQYPFWNRTS GSDHVFTATHDFGSCFHTMEDRAIADGVPIFLRNSIILQTFGVTFNHPCQEVENVVIPPYISPESLHKTQKNIPVTKERDIWVFFRGKMELHPKNISGRF YSKRVRTNIWRSYGGDRRFYLQRQRFAGYQSEIARSVFCLCPLGWAPWSPRLVESVALGCVPVIIADGIRLPFPSTVRWPDISLTVAERDVGKLGDILEH V | |||
| Full Sequence |
|---|
| Protein Sequence Length: 449 Download |
| MTTHKHRRTE KNLCFKQYYK WILCFILTLY FFASFFVDHD QDHRSSTSIS KHLLTNHKPK 60 LFASRAMFES KIHDHKLGFT SQQPNIKTDV FNNLKIYVYD LPSKFNKDWL ANDRCTNHLF 120 AAEVALHKAF LSLEGDVRTE DPYEADFFFV PVYVSCNFST INGFPAIGHA RSLINDAIKL 180 VSTQYPFWNR TSGSDHVFTA THDFGSCFHT MEDRAIADGV PIFLRNSIIL QTFGVTFNHP 240 CQEVENVVIP PYISPESLHK TQKNIPVTKE RDIWVFFRGK MELHPKNISG RFYSKRVRTN 300 IWRSYGGDRR FYLQRQRFAG YQSEIARSVF CLCPLGWAPW SPRLVESVAL GCVPVIIADG 360 IRLPFPSTVR WPDISLTVAE RDVGKLGDIL EHVAATNLSV IQRNLEDPSV RRALMFNVPS 420 REGDATWQVL EALSKKLNRS VRRSNSFL* 480 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 5.0e-68 | 94 | 390 | 305 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0005794 | Golgi apparatus |
| GO:0009834 | secondary cell wall biogenesis |
| GO:0010417 | glucuronoxylan biosynthetic process |
| GO:0015020 | glucuronosyltransferase activity |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | AAX33322.1 | 0 | 5 | 442 | 11 | 435 | secondary cell wall-related glycosyltransferase family 47 [Populus tremula x Populus tremuloides] |
| GenBank | ABI64067.1 | 0 | 5 | 442 | 11 | 435 | glycosyltransferase GT47C [Populus tremula x Populus alba] |
| RefSeq | NP_850113.2 | 0 | 1 | 448 | 1 | 448 | FRA8 (FRAGILE FIBER 8); glucuronosyltransferase/ transferase [Arabidopsis thaliana] |
| RefSeq | XP_002314302.1 | 0 | 5 | 442 | 31 | 455 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002523710.1 | 0 | 4 | 442 | 28 | 454 | transferase, putative [Ricinus communis] |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| xylogalacturonan biosynthesis | RXN-9589 | EC-2.4.2.41 | xylogalacturonan β-1,3-xylosyltransferase |
