| Basic Information | |
|---|---|
| Species | Arabidopsis thaliana |
| Cazyme ID | AT3G42180.1 |
| Family | GT47 |
| Protein Properties | Length: 471 Molecular Weight: 54268.1 Isoelectric Point: 9.305 |
| Chromosome | Chromosome/Scaffold: 3 Start: 14324274 End: 14328676 |
| Description | exostosin family protein, putative, expressed |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT47 | 132 | 421 | 0 |
| KTFKVWSYKEGEQPLVHDGPVNDIYGIEGQFIDELSYVMGGPSGRFRASRPEEAHAFFLPFSVANIVHYVYQPITSPADFNRARLHRIFNDYVDVVAHKH PFWNQSNGADHFMVSCHDWAPDVPDSKPEFFKNFMRGLCNANTSEGFRRNIDFSIPEINIPKRKLKPPFMGQNPENRTILAFFAGRAHGYIREVLFSHWK GKDKDVQVYDHLTKGQNYHELIGHSKFCLCPSGYEVASPREVEAIYSGCVPVVISDNYSLPFNDVLDWSKFSVEIPVDKIPDIKKILQEI | |||
| Full Sequence |
|---|
| Protein Sequence Length: 471 Download |
| MSNNSSKSFC LLGFPLILIL LLSFLLFSSF PNNESPPQQF FSSLTMSSLL VHTNALQSSS 60 SSSSLYSPPI TVKRRSNLEK REEELRKARA AIRRAVRFKN CTSNEEVITY IPTGQIYRNS 120 FAFHQSHIEM MKTFKVWSYK EGEQPLVHDG PVNDIYGIEG QFIDELSYVM GGPSGRFRAS 180 RPEEAHAFFL PFSVANIVHY VYQPITSPAD FNRARLHRIF NDYVDVVAHK HPFWNQSNGA 240 DHFMVSCHDW APDVPDSKPE FFKNFMRGLC NANTSEGFRR NIDFSIPEIN IPKRKLKPPF 300 MGQNPENRTI LAFFAGRAHG YIREVLFSHW KGKDKDVQVY DHLTKGQNYH ELIGHSKFCL 360 CPSGYEVASP REVEAIYSGC VPVVISDNYS LPFNDVLDWS KFSVEIPVDK IPDIKKILQE 420 IPHDKYLRMY RNVMKVRRHF VVNRPAQPFD VIHMILHSVW LRRLNIRLPS * 480 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 3.0e-56 | 130 | 404 | 294 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0003824 | catalytic activity |
| GO:0008150 | biological_process |
| GO:0012505 | endomembrane system |
| GO:0016020 | membrane |
| GO:0016757 | transferase activity, transferring glycosyl groups |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ABA18105.1 | 0 | 46 | 470 | 1 | 423 | exostosin family protein [Capsella rubella] |
| GenBank | ABA18110.1 | 0 | 131 | 470 | 1 | 340 | exostosin family protein [Arabidopsis arenosa] |
| GenBank | ABG48476.1 | 0 | 46 | 470 | 1 | 425 | At3g42180 [Arabidopsis thaliana] |
| EMBL | CAB68119.1 | 0 | 131 | 470 | 1 | 340 | putative protein [Arabidopsis thaliana] |
| RefSeq | NP_189804.4 | 0 | 1 | 470 | 1 | 470 | catalytic/ transferase, transferring glycosyl groups [Arabidopsis thaliana] |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| xylogalacturonan biosynthesis | RXN-9589 | EC-2.4.2.41 | xylogalacturonan β-1,3-xylosyltransferase |
