| Basic Information | |
|---|---|
| Species | Arabidopsis thaliana |
| Cazyme ID | AT4G22580.1 |
| Family | GT47 |
| Protein Properties | Length: 436 Molecular Weight: 50360.8 Isoelectric Point: 7.7385 |
| Chromosome | Chromosome/Scaffold: 4 Start: 11889098 End: 11890725 |
| Description | exostosin family domain containing protein, expressed |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT47 | 37 | 383 | 0 |
| CTNRWIHIRTLPSRFNLDLLSTCNRYPITDDLCPYLANHGLGPKTHTRTRSWYRTDPLLLELIFHRRILEYPCLTPDPNLASAIYLPYYAGIDSLRYLYG PDLNSSADHGSDLLEFLTRDQPEIWSRRSGHDHFLVMARPAWDFSQPLTVDPPIWGTSFLERREFFNLTALTLESRYWPWQEQAVPYPTSFHPHSLPFLE SWIRRVRRSRRTSLMLFAGGGGTSSSPNIRRSIRLECTSINATQSDNKICDFVDCSNGICEHDPIRFMRPMLQSSFCLQPPGDTPTRKATFDGIIAGCIP VFFEDQTAKMQYKWHLPESEFAEFSVTIPKEDVVFRGVRIQDVLMSI | |||
| Full Sequence |
|---|
| Protein Sequence Length: 436 Download |
| MASKSTVTTL TIFFFFFFFF IEPKVQSQQI SAVDSECTNR WIHIRTLPSR FNLDLLSTCN 60 RYPITDDLCP YLANHGLGPK THTRTRSWYR TDPLLLELIF HRRILEYPCL TPDPNLASAI 120 YLPYYAGIDS LRYLYGPDLN SSADHGSDLL EFLTRDQPEI WSRRSGHDHF LVMARPAWDF 180 SQPLTVDPPI WGTSFLERRE FFNLTALTLE SRYWPWQEQA VPYPTSFHPH SLPFLESWIR 240 RVRRSRRTSL MLFAGGGGTS SSPNIRRSIR LECTSINATQ SDNKICDFVD CSNGICEHDP 300 IRFMRPMLQS SFCLQPPGDT PTRKATFDGI IAGCIPVFFE DQTAKMQYKW HLPESEFAEF 360 SVTIPKEDVV FRGVRIQDVL MSIPKEEVTR MRERVIEMMP RVMYRRHGAS MGLMNKKDAV 420 DIAIDGVLDR IISRV* 480 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 1.0e-47 | 86 | 370 | 299 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0003824 | catalytic activity |
| GO:0012505 | endomembrane system |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | NP_193989.1 | 0 | 1 | 435 | 1 | 435 | exostosin family protein [Arabidopsis thaliana] |
| RefSeq | XP_002267390.1 | 0 | 36 | 435 | 32 | 438 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002304426.1 | 0 | 21 | 435 | 14 | 429 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002329867.1 | 0 | 1 | 435 | 1 | 432 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002529790.1 | 0 | 12 | 435 | 9 | 449 | catalytic, putative [Ricinus communis] |
