| Basic Information | |
|---|---|
| Species | Arabidopsis thaliana |
| Cazyme ID | AT5G11610.2 |
| Family | GT47 |
| Protein Properties | Length: 454 Molecular Weight: 51993.9 Isoelectric Point: 10.1687 |
| Chromosome | Chromosome/Scaffold: 5 Start: 3735350 End: 3738217 |
| Description | exostosin family protein, putative, expressed |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT47 | 218 | 444 | 0 |
| QTLKVYVYSEGDRPIFHQPEAIMEGIYASEGWFMKLMESSHRFLTKDPTKAHLFYIPFSSRILQQKLYVHDSHSRNNLVKYLGNYIDLIASNYPSWNRTC GSDHFFTACHDWAPTETRGPYINCIRALCNADVGIDFVVGKDVSLPETKVSSLQNPNGKIGGSRPSKRTILAFFAGSLHGYVRPILLNQWSSRPEQDMKI FNRIDHKSYIRYMKRSRFCVCAKGYEC | |||
| Full Sequence |
|---|
| Protein Sequence Length: 454 Download |
| MDQSRVLRFI GQVETCRVVL LMVLVVAFVS GLQYFELSPV LLSIVSPGNS TISEFRKSND 60 TTKSAENETF LASQEASTGL KPYNRTTEVL KSSEHKFLND SHKIEASGQR RRSNETASSL 120 HPLQPKIPQI RKKYPHRSIT KPPSIVISIK QMNNMILKRH NDPKNSLAPL WGSKVDQELK 180 TARDKIKKAA LVKKDDTLYA PLYHNISIFK RSYELMEQTL KVYVYSEGDR PIFHQPEAIM 240 EGIYASEGWF MKLMESSHRF LTKDPTKAHL FYIPFSSRIL QQKLYVHDSH SRNNLVKYLG 300 NYIDLIASNY PSWNRTCGSD HFFTACHDWA PTETRGPYIN CIRALCNADV GIDFVVGKDV 360 SLPETKVSSL QNPNGKIGGS RPSKRTILAF FAGSLHGYVR PILLNQWSSR PEQDMKIFNR 420 IDHKSYIRYM KRSRFCVCAK GYECLCRRKR SRI* 480 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 3.0e-35 | 220 | 443 | 244 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0003824 | catalytic activity |
| GO:0008150 | biological_process |
| GO:0012505 | endomembrane system |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| DDBJ | BAC42362.1 | 0 | 1 | 444 | 1 | 444 | unknown protein [Arabidopsis thaliana] |
| RefSeq | NP_196722.1 | 0 | 1 | 444 | 1 | 444 | exostosin family protein [Arabidopsis thaliana] |
| RefSeq | NP_974766.1 | 0 | 1 | 453 | 1 | 453 | exostosin family protein [Arabidopsis thaliana] |
| RefSeq | XP_002309547.1 | 0 | 104 | 444 | 29 | 368 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002516500.1 | 0 | 142 | 444 | 51 | 353 | catalytic, putative [Ricinus communis] |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| xylogalacturonan biosynthesis | RXN-9589 | EC-2.4.2.41 | xylogalacturonan β-1,3-xylosyltransferase |
