y
Basic Information | |
---|---|
Species | Arabidopsis thaliana |
Cazyme ID | AT5G34940.3 |
Family | GH79 |
Protein Properties | Length: 383 Molecular Weight: 42594.2 Isoelectric Point: 5.221 |
Chromosome | Chromosome/Scaffold: 5 Start: 13235829 End: 13238718 |
Description | heparanase-like protein precursor, putative, expressed |
View CDS |
Signature Domain Download full data set without filtering | |||
---|---|---|---|
Family | Start | End | Evalue |
GH79 | 45 | 381 | 0 |
DEDFICATLDWWPPEKCDYGSCSWDHASILNLDLTIVVPISKNTAFAPLKIRIGGTLQDIVIYETPDSKQPCLPFTKNSSILFGYTQGCLPMRRWDELNA FFRKTGTKVIFGLNALSGRSIKSNGEAIGAWNYTNAESFIRFTAENNYTIDGWELGNELCGSGVGARVGANQYAIDTINLRNIVNRVYKNVSPMPLVIGP GGFFEVDWFTEYLNKAENSLNATTRHIYDLGPGVDEHLIEKILNPSYLDQEAKSFRSLKNIIKNSSTKAVAWVGESGGAYNSGRNLVSNAFVYSFWYLDQ LGMASLYDTKTYCRQSLIGGNYGLLNTTNFTPNPDYY |
Full Sequence |
---|
Protein Sequence Length: 383 Download |
MAYRQILAIV LFLCVFQFLD CTVSSAVEEN GTVFVYGRAA VGTIDEDFIC ATLDWWPPEK 60 CDYGSCSWDH ASILNLDLTI VVPISKNTAF APLKIRIGGT LQDIVIYETP DSKQPCLPFT 120 KNSSILFGYT QGCLPMRRWD ELNAFFRKTG TKVIFGLNAL SGRSIKSNGE AIGAWNYTNA 180 ESFIRFTAEN NYTIDGWELG NELCGSGVGA RVGANQYAID TINLRNIVNR VYKNVSPMPL 240 VIGPGGFFEV DWFTEYLNKA ENSLNATTRH IYDLGPGVDE HLIEKILNPS YLDQEAKSFR 300 SLKNIIKNSS TKAVAWVGES GGAYNSGRNL VSNAFVYSFW YLDQLGMASL YDTKTYCRQS 360 LIGGNYGLLN TTNFTPNPDY YR* 420 |
Functional Domains Download unfiltered results here | ||||||||
---|---|---|---|---|---|---|---|---|
Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 28 | 346 | 320 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
---|---|
GO Term | Description |
GO:0004566 | beta-glucuronidase activity |
GO:0008150 | biological_process |
GO:0009505 | plant-type cell wall |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
DDBJ | BAB10787.1 | 0 | 1 | 381 | 1 | 381 | unnamed protein product [Arabidopsis thaliana] |
RefSeq | NP_198344.2 | 0 | 1 | 382 | 1 | 382 | AtGUS3 (Arabidopsis thaliana glucuronidase 3); beta-glucuronidase |
RefSeq | NP_851093.1 | 0 | 1 | 381 | 1 | 381 | AtGUS3 (Arabidopsis thaliana glucuronidase 3); beta-glucuronidase |
RefSeq | XP_002324603.1 | 0 | 31 | 381 | 1 | 351 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002533671.1 | 0 | 1 | 381 | 1 | 389 | heparanase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.000007 | 142 | 381 | 124 | 352 | A Chain A, Ribonuclease-Inhibitor Complex |
PDB | 3vnz_A | 0.000007 | 142 | 381 | 124 | 352 | A Chain A, Ribonuclease-Inhibitor Complex |
PDB | 3vny_A | 0.000007 | 142 | 381 | 124 | 352 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |