Basic Information | |
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Species | Arabidopsis thaliana |
Cazyme ID | AT5G37000.1 |
Family | GT47 |
Protein Properties | Length: 548 Molecular Weight: 62552.6 Isoelectric Point: 9.7194 |
Chromosome | Chromosome/Scaffold: 5 Start: 14618107 End: 14620282 |
Description | exostosin family protein, putative, expressed |
View CDS |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 237 | 519 | 0 |
ERKLKIYVYKEGGKPIFHTPMPRGIYASEGWFMKLMESNKKFVVKDPRKAHLFYIPISIKALRSSLGLDFQTPKSLADHLKEYVDLIAGKYKFWNRTGGA DHFLVACHDWGNKLTTKTMKNSVRSLCNSNVAQGFRIGTDTALPVTYIRSSEAPLEYLGGKTSSERKILAFFAGSMHGYLRPILVKLWENKEPDMKIFGP MPRDPKSKKQYREYMKSSRYCICARGYEVHTPRVVEAIINECVPVIIADNYVPPFFEVLNWEEFAVFVEEKDIPNLRNILLSI |
Full Sequence |
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Protein Sequence Length: 548 Download |
MRIITRFHHS DIRRLLLGII VIAGFVVLLV QCFGIPCRNS FCLSPIKVSV IELTNSNVTQ 60 VSVMNYTNLS DDDDEELENK KEDLDSENDV VISKEKVEMN VSFIAIGNIS LRNPKMVVVS 120 SESESDPNSV MIRVKDSRKG NVLSLRRHKQ GSAISISQMN SLLIQSLSSF KSPKPRWSSA 180 RDSEMLSARS EIEKVSLVHD FLGLNPLVYR NISKFLRSGD MSRFSMCCLF RSYDLMERKL 240 KIYVYKEGGK PIFHTPMPRG IYASEGWFMK LMESNKKFVV KDPRKAHLFY IPISIKALRS 300 SLGLDFQTPK SLADHLKEYV DLIAGKYKFW NRTGGADHFL VACHDWGNKL TTKTMKNSVR 360 SLCNSNVAQG FRIGTDTALP VTYIRSSEAP LEYLGGKTSS ERKILAFFAG SMHGYLRPIL 420 VKLWENKEPD MKIFGPMPRD PKSKKQYREY MKSSRYCICA RGYEVHTPRV VEAIINECVP 480 VIIADNYVPP FFEVLNWEEF AVFVEEKDIP NLRNILLSIP EDRYIGMQAR VKAVQQHFLW 540 HKKPPSS* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 7.0e-66 | 236 | 519 | 304 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0003824 | catalytic activity |
GO:0008150 | biological_process |
GO:0012505 | endomembrane system |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
DDBJ | BAB08970.1 | 0 | 1 | 544 | 1 | 535 | unnamed protein product [Arabidopsis thaliana] |
EMBL | CAN76867.1 | 0 | 122 | 544 | 227 | 689 | hypothetical protein [Vitis vinifera] |
EMBL | CBI28021.1 | 0 | 122 | 544 | 227 | 641 | unnamed protein product [Vitis vinifera] |
RefSeq | NP_198516.1 | 0 | 1 | 547 | 1 | 547 | exostosin family protein [Arabidopsis thaliana] |
RefSeq | XP_002280595.1 | 0 | 122 | 544 | 225 | 639 | PREDICTED: hypothetical protein [Vitis vinifera] |
Metabolic Pathways | |||
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Pathway Name | Reaction | EC | Protein Name |
xylogalacturonan biosynthesis | RXN-9589 | EC-2.4.2.41 | xylogalacturonan β-1,3-xylosyltransferase |