| Basic Information | |
|---|---|
| Species | Arabidopsis thaliana |
| Cazyme ID | AT5G44380.1 |
| Family | AA7 |
| Protein Properties | Length: 542 Molecular Weight: 60616.4 Isoelectric Point: 9.9951 |
| Chromosome | Chromosome/Scaffold: 5 Start: 17878722 End: 17881440 |
| Description | berberine and berberine like domain containing protein, expressed |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| AA7 | 86 | 536 | 0 |
| KPGFIFRPIHQSQVQASIICSKKLGIHFRVRSGGHDFEALSYVSRIEKPFILLDLSKLKQINVDIESNSAWVQPGATLGELYYRIAEKSKIHGFPAGLCT SVGIGGYMTGGGYGTLMRKYGLAGDNVLDVKMVDANGKLLDRAAMGEDLFWAIRGGGGASFGIVLAWKIKLVPVPKTVTVFTVTKTLEQDARLKTISKWQ QISSKIIEEIHIRVVLRAAGNDGNKTVTMTYLGQFLGEKGTLLKVMEKAFPELGLTQKDCTEMSWIEAALFHGGFPTGSPIEILLQLKSPLGKDYFKATS DFVKEPIPVIGLKGIFKRLIEGNTTFLNWTPYGGMMSKIPESAIPFPHRNGTLFKILYYANWLENDKTSSRKINWIKEIYNYMAPYVSSNPRQAYVNYRD LDFGQNKNNAKVNFIEAKIWGPKYFKGNFDRLVKIKTKVDPENFFRHEQSI | |||
| Full Sequence |
|---|
| Protein Sequence Length: 542 Download |
| MGNSKPLPTI SCIIVSVLYF SFYCITPTSS SASIQDQFIN CVKRNTHVSF PLEKTLFTPA 60 KNVSLFNQVL ESTAQNLQFL AKSMPKPGFI FRPIHQSQVQ ASIICSKKLG IHFRVRSGGH 120 DFEALSYVSR IEKPFILLDL SKLKQINVDI ESNSAWVQPG ATLGELYYRI AEKSKIHGFP 180 AGLCTSVGIG GYMTGGGYGT LMRKYGLAGD NVLDVKMVDA NGKLLDRAAM GEDLFWAIRG 240 GGGASFGIVL AWKIKLVPVP KTVTVFTVTK TLEQDARLKT ISKWQQISSK IIEEIHIRVV 300 LRAAGNDGNK TVTMTYLGQF LGEKGTLLKV MEKAFPELGL TQKDCTEMSW IEAALFHGGF 360 PTGSPIEILL QLKSPLGKDY FKATSDFVKE PIPVIGLKGI FKRLIEGNTT FLNWTPYGGM 420 MSKIPESAIP FPHRNGTLFK ILYYANWLEN DKTSSRKINW IKEIYNYMAP YVSSNPRQAY 480 VNYRDLDFGQ NKNNAKVNFI EAKIWGPKYF KGNFDRLVKI KTKVDPENFF RHEQSIPPMP 540 Y* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| COG0277 | GlcD | 3.0e-15 | 98 | 256 | 170 | + FAD/FMN-containing dehydrogenases [Energy production and conversion] | ||
| pfam08031 | BBE | 7.0e-19 | 479 | 537 | 59 | + Berberine and berberine like. This domain is found in the berberine bridge and berberine bridge- like enzymes which are involved in the biosynthesis of numerous isoquinoline alkaloids. They catalyze the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine. | ||
| pfam01565 | FAD_binding_4 | 1.0e-21 | 87 | 226 | 141 | + FAD binding domain. This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyzes the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyzes the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidises the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0003824 | catalytic activity |
| GO:0005618 | cell wall |
| GO:0006979 | response to oxidative stress |
| GO:0008762 | UDP-N-acetylmuramate dehydrogenase activity |
| GO:0009055 | electron carrier activity |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | AAL24314.1 | 0 | 1 | 540 | 1 | 541 | berberine bridge enzyme-like protein [Arabidopsis thaliana] |
| RefSeq | NP_199251.1 | 0 | 1 | 541 | 1 | 541 | FAD-binding domain-containing protein [Arabidopsis thaliana] |
| RefSeq | NP_199252.1 | 0 | 1 | 540 | 1 | 541 | FAD-binding domain-containing protein [Arabidopsis thaliana] |
| RefSeq | NP_199253.1 | 0 | 1 | 539 | 1 | 536 | FAD-binding domain-containing protein [Arabidopsis thaliana] |
| RefSeq | XP_002523164.1 | 0 | 31 | 540 | 26 | 532 | Reticuline oxidase precursor, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vte_A | 0 | 32 | 540 | 1 | 514 | A Chain A, Crystal Structure Of Tetrahydrocannabinolic Acid Synthase From Cannabis Sativa |
| PDB | 4dns_B | 0 | 26 | 539 | 1 | 496 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| PDB | 4dns_A | 0 | 26 | 539 | 1 | 496 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| PDB | 3tsj_B | 0 | 60 | 539 | 26 | 496 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| PDB | 3tsj_A | 0 | 60 | 539 | 26 | 496 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| cannabinoid biosynthesis | RXN-7854 | EC-1.21.3 | tetrahydrocannabinolic acid synthase |
