| Basic Information | |
|---|---|
| Species | Arabidopsis thaliana |
| Cazyme ID | AT5G44930.2 |
| Family | GT47 |
| Protein Properties | Length: 444 Molecular Weight: 50996.8 Isoelectric Point: 9.9381 |
| Chromosome | Chromosome/Scaffold: 5 Start: 18140230 End: 18142144 |
| Description | exostosin family domain containing protein, expressed |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT47 | 64 | 366 | 0 |
| KTKVYMYELPTNFTYGVIEQHGGEKSDDVTGLKYPGHQHMHEWYLYSDLTRPEVKRVGSPIVRVFDPAEADLFYVSAFSSLSLIVDSGRPGFGYSDEEMQ ESLVSWLESQEWWRRNNGRDHVIVAGDPNALKRVMDRVKNAVLLVTDFDRLRADQGSLVKDVIIPYSHRIDAYEGELGVKQRTNLLFFMGNRYRKDGGKV RDLLFKLLEKEEDVVIKRGTQSRENMRAVKQGMHTSKFCLHLAGDTSSACRLFDAIASLCVPVIVSDGIELPFEDVIDYRKFSIFLRRDAALKPGFVVKK LRK | |||
| Full Sequence |
|---|
| Protein Sequence Length: 444 Download |
| MNPKIRKPNN SSSKKVTVSV LSVFLVFVFV NTFFYPSFYS DSGSIRRNLV DSRESFHFPG 60 NFRKTKVYMY ELPTNFTYGV IEQHGGEKSD DVTGLKYPGH QHMHEWYLYS DLTRPEVKRV 120 GSPIVRVFDP AEADLFYVSA FSSLSLIVDS GRPGFGYSDE EMQESLVSWL ESQEWWRRNN 180 GRDHVIVAGD PNALKRVMDR VKNAVLLVTD FDRLRADQGS LVKDVIIPYS HRIDAYEGEL 240 GVKQRTNLLF FMGNRYRKDG GKVRDLLFKL LEKEEDVVIK RGTQSRENMR AVKQGMHTSK 300 FCLHLAGDTS SACRLFDAIA SLCVPVIVSD GIELPFEDVI DYRKFSIFLR RDAALKPGFV 360 VKKLRKVKPG KILKYQKVMK EVRRYFDYTH LNGSVNEIWR QVTKKIPLIK LMINREKRMI 420 KRDGSDPQCS CLCSNQTGII HGV* 480 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 2.0e-71 | 66 | 367 | 313 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0003824 | catalytic activity |
| GO:0008150 | biological_process |
| GO:0012505 | endomembrane system |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | NP_199306.1 | 0 | 1 | 443 | 1 | 443 | ARAD2 (ARABINAN DEFICIENT 2); catalytic [Arabidopsis thaliana] |
| RefSeq | NP_850241.1 | 0 | 64 | 443 | 59 | 447 | ARAD1 (ARABINAN DEFICIENT 1); catalytic/ transferase, transferring glycosyl groups [Arabidopsis thaliana] |
| RefSeq | XP_002318294.1 | 0 | 69 | 439 | 1 | 378 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002322391.1 | 0 | 19 | 440 | 15 | 454 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002523645.1 | 0 | 14 | 440 | 10 | 449 | catalytic, putative [Ricinus communis] |
