y
Basic Information | |
---|---|
Species | Aquilegia coerulea |
Cazyme ID | Aquca_002_00771.2 |
Family | GH79 |
Protein Properties | Length: 443 Molecular Weight: 49232.9 Isoelectric Point: 7.0242 |
Chromosome | Chromosome/Scaffold: 2 Start: 5906296 End: 5908861 |
Description | glucuronidase 1 |
View CDS |
External Links |
---|
CAZyDB |
Signature Domain Download full data set without filtering | |||
---|---|---|---|
Family | Start | End | Evalue |
GH79 | 40 | 206 | 1.80067e-42 |
DDNFVCATLDWWPSTKCNYNQCPWGKAGLLTLDLKNKILSNSIKAFKSLRIRIGGSLQDQILYKVGFAIKYCHHMNRSRDGRQGFTDGCLTMERWDQIND LLNKTGAVLAFGLNGLVGRDYASNDSQFSFVGDWDTRNARDLIEYTISKGYNNVDSWELGDDPNLIH | |||
GH79 | 202 | 436 | 0 |
PNLIHKVQDPLYLDQVAQTYKDVETTVRSFPWTSAWVGEAGGAYNSGGKTVSHTYVNSFWYLDQLGMTSKFNHKVYCRQTLIGGNYGLLNTTTFVPNPDY YSALLWHRLMGKTVLSTTHNGSPYLRAYSHCSKNKPGITLLLINMSNSTSLNVSVANDLNLHNMNEESKGGNAREEYHLTPKDNNVQSDVMLLNGSPLVL TKALDIPALKPILVDPNSPIYVAPDSIVFVSLRDF |
Full Sequence |
---|
Protein Sequence Length: 443 Download |
MVLRNILLVL LISNLSLCLS LLAEDVTVTV QSVTNIGTTD DNFVCATLDW WPSTKCNYNQ 60 CPWGKAGLLT LDLKNKILSN SIKAFKSLRI RIGGSLQDQI LYKVGFAIKY CHHMNRSRDG 120 RQGFTDGCLT MERWDQINDL LNKTGAVLAF GLNGLVGRDY ASNDSQFSFV GDWDTRNARD 180 LIEYTISKGY NNVDSWELGD DPNLIHKVQD PLYLDQVAQT YKDVETTVRS FPWTSAWVGE 240 AGGAYNSGGK TVSHTYVNSF WYLDQLGMTS KFNHKVYCRQ TLIGGNYGLL NTTTFVPNPD 300 YYSALLWHRL MGKTVLSTTH NGSPYLRAYS HCSKNKPGIT LLLINMSNST SLNVSVANDL 360 NLHNMNEESK GGNAREEYHL TPKDNNVQSD VMLLNGSPLV LTKALDIPAL KPILVDPNSP 420 IYVAPDSIVF VSLRDFQAPV CA* 480 |
Functional Domains Download unfiltered results here | ||||||||
---|---|---|---|---|---|---|---|---|
Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 2.0e-29 | 199 | 267 | 70 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
pfam03662 | Glyco_hydro_79n | 3.0e-79 | 23 | 201 | 179 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
---|---|
GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI27258.1 | 0 | 22 | 441 | 23 | 523 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002274743.1 | 0 | 22 | 441 | 21 | 521 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002315010.1 | 0 | 16 | 442 | 14 | 518 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002512114.1 | 0 | 23 | 201 | 28 | 207 | Heparanase precursor, putative [Ricinus communis] |
RefSeq | XP_002512114.1 | 0 | 199 | 440 | 283 | 529 | Heparanase precursor, putative [Ricinus communis] |