| Basic Information | |
|---|---|
| Species | Aquilegia coerulea |
| Cazyme ID | Aquca_002_00771.3 |
| Family | GH79 |
| Protein Properties | Length: 435 Molecular Weight: 48930.8 Isoelectric Point: 8.442 |
| Chromosome | Chromosome/Scaffold: 2 Start: 5906296 End: 5908861 |
| Description | glucuronidase 1 |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 40 | 415 | 0 |
| DDNFVCATLDWWPSTKCNYNQCPWGKAGLLTLDLKNKILSNSIKAFKSLRIRIGGSLQDQILYKVGFAIKYCHHMNRSRDGRQGFTDGCLTMERWDQIND LLNKTGAVLAFGLNGLVGRDYASNDSQFSFVGDWDTRNARDLIEYTISKGYNNVDSWELGNELCGNKDFTQVDAKQYAKDVIALRKVIDKLYKKSTVQPK LLAPGGIYDEEWFHTFLQASGPNVVDVTTHHIYNLGPGDDPNLIHKVQDPLYLDQVAQTYKDVETTVRSFPWTSAWVGEAGGAYNSGGKTVSHTYVNSFW YLDQLGMTSKFNHKVYCRQTLIGGNYGLLNTTTFVPNPDYYSALLWHRLMGKTVLSTTHNGSPYLRAYSHCSKNKV | |||
| Full Sequence |
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| Protein Sequence Length: 435 Download |
| MVLRNILLVL LISNLSLCLS LLAEDVTVTV QSVTNIGTTD DNFVCATLDW WPSTKCNYNQ 60 CPWGKAGLLT LDLKNKILSN SIKAFKSLRI RIGGSLQDQI LYKVGFAIKY CHHMNRSRDG 120 RQGFTDGCLT MERWDQINDL LNKTGAVLAF GLNGLVGRDY ASNDSQFSFV GDWDTRNARD 180 LIEYTISKGY NNVDSWELGN ELCGNKDFTQ VDAKQYAKDV IALRKVIDKL YKKSTVQPKL 240 LAPGGIYDEE WFHTFLQASG PNVVDVTTHH IYNLGPGDDP NLIHKVQDPL YLDQVAQTYK 300 DVETTVRSFP WTSAWVGEAG GAYNSGGKTV SHTYVNSFWY LDQLGMTSKF NHKVYCRQTL 360 IGGNYGLLNT TTFVPNPDYY SALLWHRLMG KTVLSTTHNG SPYLRAYSHC SKNKVSIICV 420 IRHSIRIYNM CVKF* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 2.0e-169 | 23 | 345 | 324 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI27258.1 | 0 | 22 | 421 | 23 | 425 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002274743.1 | 0 | 22 | 421 | 21 | 423 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002315010.1 | 0 | 16 | 421 | 14 | 417 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002512114.1 | 0 | 23 | 421 | 28 | 428 | Heparanase precursor, putative [Ricinus communis] |
| RefSeq | XP_002512114.1 | 0.00000000000006 | 53 | 101 | 539 | 587 | Heparanase precursor, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.00004 | 90 | 408 | 75 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
| PDB | 3vnz_A | 0.00004 | 90 | 408 | 75 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
| PDB | 3vny_A | 0.00004 | 90 | 408 | 75 | 383 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
