y
Basic Information | |
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Species | Aquilegia coerulea |
Cazyme ID | Aquca_002_01146.1 |
Family | GH31 |
Protein Properties | Length: 930 Molecular Weight: 103493 Isoelectric Point: 6.2448 |
Chromosome | Chromosome/Scaffold: 2 Start: 8564539 End: 8569426 |
Description | alpha-xylosidase 1 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH31 | 276 | 766 | 0 |
FYFFPGSTPLAVVDQYTQFVGRPAPMPYWAIGFHQCKWGYKNVSVTEAVVDNYRKALIPVDVIWNDDDHMEGNKDFTLDPVNFPRPKMLAFLDKVHSRGM KYIVLTDPGIGVNSSYGVYQRGMANDVFIKLDGEPFLGQVWPGPVYFPDFLNPKTVAWWKDEIARFHELVPVDGLWIDMNEVSNFCSGKCTIPKDRPCPG KFGWICCLDCKNVTNTKWDEPPYKINASGKHVPLGFQTIATSAIHYNGVLEYDAHSIYGFSHTIATHKALLAINGKRPFILSRSTFVGSGKYAAHWTGDN KATWDDLRYSISTILNFGIFGMPMVGADICGFYPTPTEELCNRWIELGAFYPFSRNHANQASPNQELFVWDSVAKSARNALGMRYKILPYLYTLNYEAHT SGAPIARPIFFTFPNLTESYGLSTQFLLGSSLMVSPVLKQGTSKVKALFPPGTWYSLFDMTQTIISKEGHYLTLDAPLHVINVHVYQNTIL |
Full Sequence |
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Protein Sequence Length: 930 Download |
MFSCFHHSPS LSVLVGAVVS VFLVLSSDGV SSSFSKIGQG YSLVSIEDAP NGGLIGLLQV 60 KKKTNTYGPD IPNLQLYVKH ETQDRLRVHI TDAEKQRWEV PYDLLPREQP PTMKKSIGKS 120 RKVLYGESEI SGNKLIFSYI SDPFSFAVKR KSDGQTLFNS SSDESDPYSS LVFKDQYIEI 180 STKLPEDASL YGLGENTQSH GIKLQPNDPY TLYTTDVAAL NPEVDLYGSQ PVYMDLRNVG 240 GEAFAHAVML LNSNGMDVVY RGNSLTYKII GGVLDFYFFP GSTPLAVVDQ YTQFVGRPAP 300 MPYWAIGFHQ CKWGYKNVSV TEAVVDNYRK ALIPVDVIWN DDDHMEGNKD FTLDPVNFPR 360 PKMLAFLDKV HSRGMKYIVL TDPGIGVNSS YGVYQRGMAN DVFIKLDGEP FLGQVWPGPV 420 YFPDFLNPKT VAWWKDEIAR FHELVPVDGL WIDMNEVSNF CSGKCTIPKD RPCPGKFGWI 480 CCLDCKNVTN TKWDEPPYKI NASGKHVPLG FQTIATSAIH YNGVLEYDAH SIYGFSHTIA 540 THKALLAING KRPFILSRST FVGSGKYAAH WTGDNKATWD DLRYSISTIL NFGIFGMPMV 600 GADICGFYPT PTEELCNRWI ELGAFYPFSR NHANQASPNQ ELFVWDSVAK SARNALGMRY 660 KILPYLYTLN YEAHTSGAPI ARPIFFTFPN LTESYGLSTQ FLLGSSLMVS PVLKQGTSKV 720 KALFPPGTWY SLFDMTQTII SKEGHYLTLD APLHVINVHV YQNTILPMQQ GGLTTKDART 780 TPFSLVVTFP AGASEGEAKG KLFLDDDELP EMKLGNGQST YIEFYATVSK KTVKVWSEVQ 840 EGKFATEKGW IIEKVTVLGL DGIGEALTVE VDETPISDVS NIELNASEQM SLEKLEGDNY 900 KKSMMVEVKG LELPIGKKFV MSWQMGIKG* 960 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd06602 | GH31_MGAM_SI_GAA | 4.0e-96 | 527 | 690 | 165 | + This family includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). | ||
cd06603 | GH31_GANC_GANAB_alpha | 1.0e-104 | 296 | 677 | 388 | + This family includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in electrophoretic mobility in starch gel, GANC and GANAB have been shown to have other differences, including those of substrate specificity. GANC and GANAB are key enzymes in glycogen metabolism that hydrolyze terminal, non-reducing 1,4-linked alpha-D-glucose residues from glycogen in the endoplasmic reticulum. The GANC/GANAB family includes the alpha-glucosidase II (ModA) from Dictyostelium discoideum as well as the alpha-glucosidase II (GLS2, or ROT2 - Reversal of TOR2 lethality protein 2) from Saccharomyces cerevisiae. | ||
cd06604 | GH31_glucosidase_II_MalA | 5.0e-118 | 296 | 677 | 388 | + Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized in Bacillus thermoamyloliquefaciens where it forms a homohexamer. This family also includes the MalA alpha-glucosidase from Sulfolobus sulfataricus and the AglA alpha-glucosidase from Picrophilus torridus. MalA is part of the carbohydrate-metabolizing machinery that allows this organism to utilize carbohydrates, such as maltose, as the sole carbon and energy source. | ||
COG1501 | COG1501 | 3.0e-124 | 175 | 871 | 709 | + Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism] | ||
pfam01055 | Glyco_hydro_31 | 0 | 277 | 766 | 494 | + Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. |
Gene Ontology | |
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GO Term | Description |
GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
GO:0005975 | carbohydrate metabolic process |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CAB96077.1 | 0 | 18 | 927 | 12 | 928 | alpha-glucosidase [Solanum tuberosum] |
RefSeq | XP_002282429.1 | 0 | 18 | 929 | 9 | 924 | PREDICTED: hypothetical protein isoform 1 [Vitis vinifera] |
RefSeq | XP_002311455.1 | 0 | 31 | 929 | 9 | 910 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002315944.1 | 0 | 31 | 929 | 26 | 928 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002531635.1 | 0 | 9 | 929 | 3 | 930 | alpha-glucosidase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3w38_A | 0 | 11 | 860 | 10 | 851 | A Chain A, Glutathionylspermidine SynthetaseAMIDASE C59A COMPLEX WITH ADP AND Gsp |
PDB | 3w37_A | 0 | 11 | 860 | 10 | 851 | A Chain A, Glutathionylspermidine SynthetaseAMIDASE C59A COMPLEX WITH ADP AND Gsp |
PDB | 3lpp_D | 0 | 67 | 923 | 106 | 898 | A Chain A, Glutathionylspermidine SynthetaseAMIDASE C59A COMPLEX WITH ADP AND Gsp |
PDB | 3lpp_C | 0 | 67 | 923 | 106 | 898 | A Chain A, Glutathionylspermidine SynthetaseAMIDASE C59A COMPLEX WITH ADP AND Gsp |
PDB | 3lpp_B | 0 | 67 | 923 | 106 | 898 | A Chain A, Glutathionylspermidine SynthetaseAMIDASE C59A COMPLEX WITH ADP AND Gsp |