| Basic Information | |
|---|---|
| Species | Aquilegia coerulea |
| Cazyme ID | Aquca_020_00460.1 |
| Family | AA3 |
| Protein Properties | Length: 656 Molecular Weight: 72047 Isoelectric Point: 9.7858 |
| Chromosome | Chromosome/Scaffold: 20 Start: 3195905 End: 3200432 |
| Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| AA3 | 118 | 646 | 0 |
| ADKHYDYIIIGGGTAGCPLAATLSQNFSVLLLERGGVPFNNPNVSHMENFHISLADTSPHSASQAFLSTDGVINARARVLGGGSSINAGFYTRASPRFVR RVGWDGELVNQSYPWVERQIVKQPKLAQWQEALRSGLLEVGVSPFNGFSFDHIYGTKVGGTIFDDKGQRHTSAELLASANPHNLQVLIHASVQKIVFDRT TAGKPKAVGVIFKDENGLKHQAFLSKDKLSEVILSSGAIGSPQLLLLSGIGPKADLKKLNIPVVLDNEYVGKGMSDNPMNSIFLPTKRPIKQSLIETVGI TQMGVYIEGSSGFGQSGDSIRCHHGIMSAEIGQLVTIPPKQRTQEAIQAYMEKKKDIPYELFKGGFILQKVVGPLSTGEIKLLNTNVDDNPSITFNYFSH PYDLNRCVNGIRLMEKIVKTTHFSKLINNDKLAMDTILNMSVTANVNLIPKHTNDTKSLEQFCKDTVITIWHYHGGCHVGKVVDRDYRVMAVNSLRVVDG SVFPDSPGTNPQATVMMMGRYMGVKILRE | |||
| Full Sequence |
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| Protein Sequence Length: 656 Download |
| MFTVLSRYNT SSVRQCSERK RKSLSLGTLS TALFSFFDQF SDLFMAWVCV LKLLFCTLLP 60 LQLLLTFSLL TAVQGVKVHS NYRYPFIKEA SSFTIPPRAA QPTPSPPSSS SPYWKNIADK 120 HYDYIIIGGG TAGCPLAATL SQNFSVLLLE RGGVPFNNPN VSHMENFHIS LADTSPHSAS 180 QAFLSTDGVI NARARVLGGG SSINAGFYTR ASPRFVRRVG WDGELVNQSY PWVERQIVKQ 240 PKLAQWQEAL RSGLLEVGVS PFNGFSFDHI YGTKVGGTIF DDKGQRHTSA ELLASANPHN 300 LQVLIHASVQ KIVFDRTTAG KPKAVGVIFK DENGLKHQAF LSKDKLSEVI LSSGAIGSPQ 360 LLLLSGIGPK ADLKKLNIPV VLDNEYVGKG MSDNPMNSIF LPTKRPIKQS LIETVGITQM 420 GVYIEGSSGF GQSGDSIRCH HGIMSAEIGQ LVTIPPKQRT QEAIQAYMEK KKDIPYELFK 480 GGFILQKVVG PLSTGEIKLL NTNVDDNPSI TFNYFSHPYD LNRCVNGIRL MEKIVKTTHF 540 SKLINNDKLA MDTILNMSVT ANVNLIPKHT NDTKSLEQFC KDTVITIWHY HGGCHVGKVV 600 DRDYRVMAVN SLRVVDGSVF PDSPGTNPQA TVMMMGRYMG VKILRERLGR GGAGI* 660 |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam05199 | GMC_oxred_C | 7.0e-30 | 491 | 636 | 151 | + GMC oxidoreductase. This domain found associated with pfam00732. | ||
| TIGR03970 | Rv0697 | 5.0e-33 | 123 | 636 | 569 | + dehydrogenase, Rv0697 family. This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function. | ||
| TIGR01810 | betA | 1.0e-36 | 123 | 636 | 573 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
| COG2303 | BetA | 9.0e-52 | 118 | 650 | 579 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
| PLN02785 | PLN02785 | 0 | 74 | 655 | 582 | + Protein HOTHEAD | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAN78644.1 | 0 | 68 | 649 | 19 | 606 | hypothetical protein [Vitis vinifera] |
| EMBL | CBI35951.1 | 0 | 68 | 655 | 19 | 593 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002275841.1 | 0 | 122 | 655 | 53 | 584 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002329018.1 | 0 | 70 | 655 | 20 | 591 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002527404.1 | 0 | 119 | 650 | 63 | 593 | glucose-methanol-choline (gmc) oxidoreductase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3red_L | 0 | 122 | 647 | 27 | 518 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| PDB | 3red_K | 0 | 122 | 647 | 27 | 518 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| PDB | 3red_J | 0 | 122 | 647 | 27 | 518 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| PDB | 3red_I | 0 | 122 | 647 | 27 | 518 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
| PDB | 3red_H | 0 | 122 | 647 | 27 | 518 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
