Basic Information | |
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Species | Aquilegia coerulea |
Cazyme ID | Aquca_037_00334.1 |
Family | AA7 |
Protein Properties | Length: 571 Molecular Weight: 62530.8 Isoelectric Point: 6.27 |
Chromosome | Chromosome/Scaffold: 37 Start: 2316679 End: 2318784 |
Description | FAD-binding Berberine family protein |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
AA7 | 83 | 299 | 0 |
TKPIAIVLPQTQEQLASTVLCCRQAMLVIRIRCGGHSYEGLSSVASNGVPFVIIDMMNLNRVSVDMESKTAWVEGGATLGETYYAISESSDSHGFSAGSC PTVGSGGHIAGGGFGLLSRKYGLAADNVVDALVLDADGRILDREAMGEDVFWAIRGGGGGVFGIIYAWKIRLVQIPQVVTSFIVSRPGTLQQVAELVHKW QFVGPQLEDAFYLSAFV |
Full Sequence |
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Protein Sequence Length: 571 Download |
MVKCKRPPSL LFLFIFIMIT LVAVPSLSSP TDLIKYCLTI KHVTNFTLIP PTSTRSSDND 60 SSLYYNLLNF SIQNLRFVEP SFTKPIAIVL PQTQEQLAST VLCCRQAMLV IRIRCGGHSY 120 EGLSSVASNG VPFVIIDMMN LNRVSVDMES KTAWVEGGAT LGETYYAISE SSDSHGFSAG 180 SCPTVGSGGH IAGGGFGLLS RKYGLAADNV VDALVLDADG RILDREAMGE DVFWAIRGGG 240 GGVFGIIYAW KIRLVQIPQV VTSFIVSRPG TLQQVAELVH KWQFVGPQLE DAFYLSAFVG 300 AGLPEVKSIG ISATFKGFYL GPKAEATTII NGTFPELGIQ DEDCKQMSWI ESVLFFSGLP 360 NGSCLSDLKD RFLHDKGYFK AKSDYVKIVI PMGGIRSALK ILAKEPKGEG NLFTIQYQVA 420 WNEQDQGNKK SNELIDWMTG FYQFMTPFVA TEPRTAYVNY VDLDLGKMDM IISASSNAVE 480 TARRWGEKYF LNNYDRLVQI KTVIDPNNVF SNQQGIPPMS GTIGTLDAQI NAAPSKICDL 540 NVKATASGDD KENNLRSSYI IIWSTCTARF * |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
TIGR01679 | bact_FAD_ox | 0.003 | 85 | 162 | 79 | + FAD-linked oxidoreductase. This model represents a family of bacterial oxidoreductases with covalently linked FAD, closely related to two different eukaryotic oxidases, L-gulonolactone oxidase (EC 1.1.3.8) from rat and D-arabinono-1,4-lactone oxidase (EC 1.1.3.37) from Saccharomyces cerevisiae. | ||
pfam08031 | BBE | 3.0e-16 | 456 | 517 | 62 | + Berberine and berberine like. This domain is found in the berberine bridge and berberine bridge- like enzymes which are involved in the biosynthesis of numerous isoquinoline alkaloids. They catalyze the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine. | ||
COG0277 | GlcD | 4.0e-17 | 85 | 518 | 455 | + FAD/FMN-containing dehydrogenases [Energy production and conversion] | ||
pfam01565 | FAD_binding_4 | 3.0e-17 | 85 | 224 | 141 | + FAD binding domain. This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyzes the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyzes the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidises the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan. |
Gene Ontology | |
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GO Term | Description |
GO:0008762 | UDP-N-acetylmuramate dehydrogenase activity |
GO:0016491 | oxidoreductase activity |
GO:0050660 | flavin adenine dinucleotide binding |
GO:0055114 | oxidation-reduction process |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI16966.1 | 0 | 1 | 519 | 277 | 767 | unnamed protein product [Vitis vinifera] |
EMBL | CBI16966.1 | 3e-28 | 362 | 495 | 66 | 222 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002264336.1 | 0 | 9 | 519 | 7 | 534 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002329230.1 | 0 | 25 | 530 | 8 | 537 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002533924.1 | 0 | 17 | 519 | 14 | 535 | d-lactate dehydrogenase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3fw9_A | 0 | 37 | 520 | 5 | 495 | A Chain A, Structure Of Berberine Bridge Enzyme In Complex With (S)-Scoulerine |
PDB | 3d2j_A | 0 | 13 | 520 | 7 | 520 | A Chain A, Structure Of Berberine Bridge Enzyme In Complex With (S)-Scoulerine |
PDB | 3d2h_A | 0 | 13 | 520 | 7 | 520 | A Chain A, Structure Of Berberine Bridge Enzyme In Complex With (S)-Scoulerine |
PDB | 3d2d_A | 0 | 13 | 520 | 7 | 520 | A Chain A, Structure Of Berberine Bridge Enzyme In Complex With (S)-Reticuline |
PDB | 4ec3_A | 0 | 37 | 520 | 11 | 501 | A Chain A, Structure Of Berberine Bridge Enzyme, H174a Variant In Complex With (S)-Reticuline |