| Basic Information | |
|---|---|
| Species | Aquilegia coerulea |
| Cazyme ID | Aquca_042_00116.2 |
| Family | GT47 |
| Protein Properties | Length: 510 Molecular Weight: 58091.6 Isoelectric Point: 8.5375 |
| Chromosome | Chromosome/Scaffold: 42 Start: 1238993 End: 1246347 |
| Description | Exostosin family protein |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GT47 | 78 | 433 | 0 |
| SIKVYLADLPSSFNYDLLTQYWSFTSDSRIGSDIDNDLRRSIRSSRSNFSSSMGNLHFPPFPENPIIKQYSAEYWILGDLMTPQKLRGSSFAERVFNYRD ADVVFVPFFATLSAEMQLIMGKSVFRKKVNENEDYVRQKNLMDLIRSSEAWKQSGGRDHVFVLTDPVAMWHVRDEIGPAVLLVVDFGGWYRHDLKASNGS SSDMIQHTQVSLLKDVIVPYTHLLPRLHLSDNQNRRTLLYFKGAKHRHRGGVVREKLWDLLVDEPDVVMEEGFPNSTGKEQSIKGMRSSEFCLHPAGDTP TSCRLFDAILSLCIPVIVSDDIELPFEGMVDYSDFSIFVPVSDALQPNWLIRHLQS | |||
| Full Sequence |
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| Protein Sequence Length: 510 Download |
| MLQRTPTYRE RESKIAMAPK TSFMNLVQCT TPLLFISLSL FFLLPLSLFF LLYSTHSHFY 60 PTSFSLSSPS SSLIPTTSIK VYLADLPSSF NYDLLTQYWS FTSDSRIGSD IDNDLRRSIR 120 SSRSNFSSSM GNLHFPPFPE NPIIKQYSAE YWILGDLMTP QKLRGSSFAE RVFNYRDADV 180 VFVPFFATLS AEMQLIMGKS VFRKKVNENE DYVRQKNLMD LIRSSEAWKQ SGGRDHVFVL 240 TDPVAMWHVR DEIGPAVLLV VDFGGWYRHD LKASNGSSSD MIQHTQVSLL KDVIVPYTHL 300 LPRLHLSDNQ NRRTLLYFKG AKHRHRGGVV REKLWDLLVD EPDVVMEEGF PNSTGKEQSI 360 KGMRSSEFCL HPAGDTPTSC RLFDAILSLC IPVIVSDDIE LPFEGMVDYS DFSIFVPVSD 420 ALQPNWLIRH LQSFSKFQKN TLRQSMAHIQ HIFEYDNGHP GGVGPVPSDG AVNHVWKKVY 480 QKLPMIKEAM VREKRKPKGV SVPLRCHCT* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 1.0e-55 | 136 | 434 | 311 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | NP_564443.1 | 0 | 66 | 508 | 41 | 476 | exostosin family protein [Arabidopsis thaliana] |
| RefSeq | XP_002270238.1 | 0 | 21 | 509 | 9 | 440 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002325567.1 | 0 | 29 | 509 | 13 | 476 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002327326.1 | 0 | 44 | 509 | 1 | 449 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002533317.1 | 0 | 61 | 509 | 36 | 478 | catalytic, putative [Ricinus communis] |
