| Basic Information | |
|---|---|
| Species | Aquilegia coerulea |
| Cazyme ID | Aquca_057_00157.1 |
| Family | GH89 |
| Protein Properties | Length: 780 Molecular Weight: 89478.4 Isoelectric Point: 6.6765 |
| Chromosome | Chromosome/Scaffold: 57 Start: 1583819 End: 1592116 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
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| Family | Start | End | Evalue |
| GH89 | 103 | 775 | 0 |
| GAQLSSVPNPGSLPPVKDKGVIIQRPVPWNYYQNVVTSSYSYVWWDWERWEKELDWMALQGINLPLAFTGQEAIWEKVFKNFNTSKKDLDGFFGGPAFLA WARMGNLHAWGGPLQQSWLDQQLALQKLILTRMVELGMTPVLPSFSGNVPASLKRIFPSANITRLGDWNTVNGDPRWCCTYLLDPSDPLFVEIGDAFIRQ QMEEYGDITDIYNCDTFNENSPPTNDPAYISLLGAAVYKAMSKTDKDAVWLMQGWLFSSDSAFWKPPQMKALLHSVPLGKMIVLDLFADVKPIWETSSQF YGTPYVWCLLHNFGGNIEMYGILDVISSGPVDARISQNSTMVGVGMCMEGIEQNPVVYELMSEMAFRSEKVPLKEWLKSYSYRRYGKKDPQIDSAWEILH QTIYNCTDGIADHNKDFIVQFPDWDPSDYFHTNMSKETHVHNLFAHNNTKRFFLRETTTDLPRAHLWYSTEEVIIALQLFLDAGSHLAGSLTYRYDLVDL MRQVLSKLANQVYLDAMTAFQQKNAKALTLQSLKFVELIKDIDTLLASDDNFLLGTWIESAKNLAASPREMRQYEWNARTQVTMWYDTRKTNQSKLHDYA NKFWSGLLEKYYLPRASTYFTYLLASLVQKEGFKLEEWRREWISFSNKWQSGTELYPVRAQGDALAISKALSK | |||
| Full Sequence |
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| Protein Sequence Length: 780 Download |
| MEVLLTKIET KRVSSYVQED AVIGVLKRLL PNHLSSFEFK IVPKHIEPFL FLRWICSCTM 60 VHLRTSPTSY VCGGYSCFWI KNAKTGNAKG KEIMYAFIED TSGAQLSSVP NPGSLPPVKD 120 KGVIIQRPVP WNYYQNVVTS SYSYVWWDWE RWEKELDWMA LQGINLPLAF TGQEAIWEKV 180 FKNFNTSKKD LDGFFGGPAF LAWARMGNLH AWGGPLQQSW LDQQLALQKL ILTRMVELGM 240 TPVLPSFSGN VPASLKRIFP SANITRLGDW NTVNGDPRWC CTYLLDPSDP LFVEIGDAFI 300 RQQMEEYGDI TDIYNCDTFN ENSPPTNDPA YISLLGAAVY KAMSKTDKDA VWLMQGWLFS 360 SDSAFWKPPQ MKALLHSVPL GKMIVLDLFA DVKPIWETSS QFYGTPYVWC LLHNFGGNIE 420 MYGILDVISS GPVDARISQN STMVGVGMCM EGIEQNPVVY ELMSEMAFRS EKVPLKEWLK 480 SYSYRRYGKK DPQIDSAWEI LHQTIYNCTD GIADHNKDFI VQFPDWDPSD YFHTNMSKET 540 HVHNLFAHNN TKRFFLRETT TDLPRAHLWY STEEVIIALQ LFLDAGSHLA GSLTYRYDLV 600 DLMRQVLSKL ANQVYLDAMT AFQQKNAKAL TLQSLKFVEL IKDIDTLLAS DDNFLLGTWI 660 ESAKNLAASP REMRQYEWNA RTQVTMWYDT RKTNQSKLHD YANKFWSGLL EKYYLPRAST 720 YFTYLLASLV QKEGFKLEEW RREWISFSNK WQSGTELYPV RAQGDALAIS KALSKKYLG* 780 |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12972 | NAGLU_C | 2.0e-105 | 477 | 777 | 301 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 133 | 472 | 340 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
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| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 1 | 778 | 91 | 867 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC75285.1 | 0 | 18 | 778 | 56 | 811 | hypothetical protein OsI_11626 [Oryza sativa Indica Group] |
| GenBank | EEE59081.1 | 0 | 18 | 778 | 56 | 811 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
| RefSeq | XP_002273084.1 | 0 | 1 | 778 | 26 | 802 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 1 | 779 | 29 | 806 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
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| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 107 | 768 | 246 | 867 | A Chain A, Crystal Structure Of Rice Bglu1 E386s Mutant |
| PDB | 2vcb_A | 0 | 107 | 768 | 246 | 867 | A Chain A, Crystal Structure Of Rice Bglu1 E386s Mutant |
| PDB | 2vca_A | 0 | 107 | 768 | 246 | 867 | A Chain A, Crystal Structure Of Rice Bglu1 E386s Mutant |
| PDB | 2vc9_A | 0 | 107 | 768 | 246 | 867 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 107 | 768 | 269 | 890 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| HO783455 | 323 | 278 | 600 | 0 |
| HO783455 | 148 | 609 | 756 | 0 |
| GT627657 | 271 | 180 | 450 | 0 |
| GT622356 | 273 | 253 | 525 | 0 |
| JG639310 | 285 | 384 | 668 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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