| Basic Information | |
|---|---|
| Species | Aquilegia coerulea |
| Cazyme ID | Aquca_057_00157.4 |
| Family | GH89 |
| Protein Properties | Length: 441 Molecular Weight: 49997.1 Isoelectric Point: 5.1172 |
| Chromosome | Chromosome/Scaffold: 57 Start: 1585182 End: 1592249 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
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| Family | Start | End | Evalue |
| GH89 | 1 | 438 | 0 |
| MALQGINLPLAFTGQEAIWEKVFKNFNTSKKDLDGFFGGPAFLAWARMGNLHAWGGPLQQSWLDQQLALQKLILTRMVELGMTPVLPSFSGNVPASLKRI FPSANITRLGDWNTVNGDPRWCCTYLLDPSDPLFVEIGDAFIRQQMEEYGDITDIYNCDTFNENSPPTNDPAYISLLGAAVYKAMSKTDKDAVWLMQGWL FSSDSAFWKPPQMKALLHSVPLGKMIVLDLFADVKPIWETSSQFYGTPYVWCLLHNFGGNIEMYGILDVISSGPVDARISQNSTMVGVGMCMEGIEQNPV VYELMSEMAFRSEKVPLKEWLKSYSYRRYGKKDPQIDSAWEILHQTIYNCTDGIADHNKDFIVQFPDWDPSDYFHTNMSKETHVHNLFAHNNTKRFFLRE TTTDLPRAHLWYSTEEVIIALQLFLDAGSHLAGSLTYR | |||
| Full Sequence |
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| Protein Sequence Length: 441 Download |
| MALQGINLPL AFTGQEAIWE KVFKNFNTSK KDLDGFFGGP AFLAWARMGN LHAWGGPLQQ 60 SWLDQQLALQ KLILTRMVEL GMTPVLPSFS GNVPASLKRI FPSANITRLG DWNTVNGDPR 120 WCCTYLLDPS DPLFVEIGDA FIRQQMEEYG DITDIYNCDT FNENSPPTND PAYISLLGAA 180 VYKAMSKTDK DAVWLMQGWL FSSDSAFWKP PQMKALLHSV PLGKMIVLDL FADVKPIWET 240 SSQFYGTPYV WCLLHNFGGN IEMYGILDVI SSGPVDARIS QNSTMVGVGM CMEGIEQNPV 300 VYELMSEMAF RSEKVPLKEW LKSYSYRRYG KKDPQIDSAW EILHQTIYNC TDGIADHNKD 360 FIVQFPDWDP SDYFHTNMSK ETHVHNLFAH NNTKRFFLRE TTTDLPRAHL WYSTEEVIIA 420 LQLFLDAGSH LAGSLTYRTL * |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12972 | NAGLU_C | 2.0e-23 | 319 | 438 | 120 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 3.0e-168 | 1 | 314 | 314 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
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| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 1 | 438 | 247 | 685 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC75285.1 | 0 | 1 | 438 | 196 | 629 | hypothetical protein OsI_11626 [Oryza sativa Indica Group] |
| GenBank | EEE59081.1 | 0 | 1 | 438 | 196 | 629 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
| RefSeq | XP_002273084.1 | 0 | 1 | 438 | 182 | 620 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 1 | 438 | 186 | 623 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
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| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 2 | 348 | 298 | 631 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vcb_A | 0 | 2 | 348 | 298 | 631 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vca_A | 0 | 2 | 348 | 298 | 631 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vc9_A | 0 | 2 | 348 | 298 | 631 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 2 | 348 | 321 | 654 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| HO783455 | 319 | 120 | 438 | 0 |
| GT627657 | 271 | 22 | 292 | 0 |
| GT622356 | 273 | 95 | 367 | 0 |
| EY072797 | 256 | 54 | 309 | 0 |
| GW865336 | 302 | 55 | 356 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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