| Basic Information | |
|---|---|
| Species | Aquilegia coerulea |
| Cazyme ID | Aquca_083_00009.1 |
| Family | GH79 |
| Protein Properties | Length: 550 Molecular Weight: 60732.1 Isoelectric Point: 7.0194 |
| Chromosome | Chromosome/Scaffold: 83 Start: 76004 End: 79475 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 54 | 542 | 0 |
| DDDFICATLDWWPPEKCDYGTCSWGRASLLNLDLNNIILLNAIKAFSPLKIRLGGTLQDKVIYDIGDPNQPCPQFIRNTSQMFGFTQGCLHMARWDELNS FFKKTGAVIIFGLNALNGRTMASDGSSVGPWDSTNAAAIMRYTVNKGYTIYAWELGNELSGNGVGTRVAAAQYVSDVMELNSVVKEIYQGFKVTPKIIAP GGFFDANWYKELVGKTPNSLDIVTHHIYNLGPGVDTHLVEKILDPSYLDNEINTFRDLKNILDTSTTSATAWVGEAGGAYNSGHNLVTNAFVFSFWYLDQ LGMASKYNTKTYCRQTLIGGNYGLLNTTTFVPNPDYYSALLWNQLMGRNVLLTNFTGTKKIRAYSHCAKQSKGIVVLLINLDGNTTVQVRLTTETAASNR IWSLNQQHISPKTRFARIPQESRKDVTTREEYHLTAKDRNLHSQIMLLNGKILAVNSSGDIPPLEPISVNLGEPIIVSPYSIVFAHIPT | |||
| Full Sequence |
|---|
| Protein Sequence Length: 550 Download |
| MGSSLYQSFG RLCFILYLIS CITVASSQNA EERGLRVEEG NAFIDGRNAI ASIDDDFICA 60 TLDWWPPEKC DYGTCSWGRA SLLNLDLNNI ILLNAIKAFS PLKIRLGGTL QDKVIYDIGD 120 PNQPCPQFIR NTSQMFGFTQ GCLHMARWDE LNSFFKKTGA VIIFGLNALN GRTMASDGSS 180 VGPWDSTNAA AIMRYTVNKG YTIYAWELGN ELSGNGVGTR VAAAQYVSDV MELNSVVKEI 240 YQGFKVTPKI IAPGGFFDAN WYKELVGKTP NSLDIVTHHI YNLGPGVDTH LVEKILDPSY 300 LDNEINTFRD LKNILDTSTT SATAWVGEAG GAYNSGHNLV TNAFVFSFWY LDQLGMASKY 360 NTKTYCRQTL IGGNYGLLNT TTFVPNPDYY SALLWNQLMG RNVLLTNFTG TKKIRAYSHC 420 AKQSKGIVVL LINLDGNTTV QVRLTTETAA SNRIWSLNQQ HISPKTRFAR IPQESRKDVT 480 TREEYHLTAK DRNLHSQIML LNGKILAVNS SGDIPPLEPI SVNLGEPIIV SPYSIVFAHI 540 PTIEVPACS* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 38 | 355 | 319 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAN81917.1 | 0 | 4 | 548 | 3 | 554 | hypothetical protein [Vitis vinifera] |
| EMBL | CBI25561.1 | 0 | 12 | 548 | 3 | 532 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002263173.1 | 0 | 4 | 548 | 7 | 558 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002283254.1 | 0 | 12 | 549 | 10 | 537 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002283260.1 | 0 | 8 | 548 | 6 | 545 | PREDICTED: hypothetical protein [Vitis vinifera] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.000007 | 149 | 442 | 122 | 408 | B Chain B, Structure Of A Cellulose Synthase - Cellulose Translocation Intermediate |
| PDB | 3vnz_A | 0.000007 | 149 | 442 | 122 | 408 | B Chain B, Structure Of A Cellulose Synthase - Cellulose Translocation Intermediate |
| PDB | 3vny_A | 0.000007 | 149 | 442 | 122 | 408 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
