| Basic Information | |
|---|---|
| Species | Brassica rapa |
| Cazyme ID | Bra004627 |
| Family | CE1 |
| Protein Properties | Length: 284 Molecular Weight: 31641.6 Isoelectric Point: 6.0301 |
| Chromosome | Chromosome/Scaffold: 05 Start: 1126609 End: 1128018 |
| Description | S-formylglutathione hydrolase |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| CE1 | 25 | 279 | 0 |
| SETLGCSMTFSIYFPPSSSSHRSPVLYWLSGLTCTDENFIIKSGAQRAASAHGIALVVPDTSPRGLNIEGEADSYDFGVGAGFYLNATQEKWKNWRMYDY VVKELPKLLSENFPQLDTARASISGHSMGGHGALTIYLKNLDKYKSVSAFAPIANPINCPWGQKAFTNYLGDNKAAWEEYDATCLISKFNNLSATILIDQ GENDQFYPDQLLPNKFEEACKKVNAPLLVRLQPGYDHSYYFIATFIEDHISHHVQ | |||
| Full Sequence |
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| Protein Sequence Length: 284 Download |
| MESGLSEIGS TKMFDGYNKR YKHNSETLGC SMTFSIYFPP SSSSHRSPVL YWLSGLTCTD 60 ENFIIKSGAQ RAASAHGIAL VVPDTSPRGL NIEGEADSYD FGVGAGFYLN ATQEKWKNWR 120 MYDYVVKELP KLLSENFPQL DTARASISGH SMGGHGALTI YLKNLDKYKS VSAFAPIANP 180 INCPWGQKAF TNYLGDNKAA WEEYDATCLI SKFNNLSATI LIDQGENDQF YPDQLLPNKF 240 EEACKKVNAP LLVRLQPGYD HSYYFIATFI EDHISHHVQA LEL* 300 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| COG1506 | DAP2 | 0.002 | 70 | 277 | 232 | + Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism] | ||
| pfam00756 | Esterase | 2.0e-61 | 25 | 274 | 262 | + Putative esterase. This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family. | ||
| COG0627 | COG0627 | 1.0e-83 | 20 | 283 | 294 | + Predicted esterase [General function prediction only] | ||
| TIGR02821 | fghA_ester_D | 2.0e-141 | 8 | 281 | 275 | + S-formylglutathione hydrolase. This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 3.1.2.12). Members in eukaryotes such as the human protein are better known as esterase D (EC 3.1.1.1), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well [Cellular processes, Detoxification]. | ||
| PLN02442 | PLN02442 | 0 | 1 | 283 | 283 | + S-formylglutathione hydrolase | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004091 | carboxylesterase activity |
| GO:0006508 | proteolysis |
| GO:0008236 | serine-type peptidase activity |
| GO:0016023 | cytoplasmic membrane-bounded vesicle |
| GO:0018738 | S-formylglutathione hydrolase activity |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | AAM65175.1 | 0 | 13 | 283 | 1 | 272 | putative esterase D [Arabidopsis thaliana] |
| GenBank | ACJ11734.1 | 0 | 1 | 283 | 1 | 284 | S-formylglutathione hydrolase [Gossypium hirsutum] |
| GenBank | ACU19052.1 | 0 | 1 | 283 | 1 | 284 | unknown [Glycine max] |
| RefSeq | NP_181684.1 | 0 | 1 | 283 | 1 | 284 | SFGH (S-FORMYLGLUTATHIONE HYDROLASE); S-formylglutathione hydrolase/ hydrolase, acting on ester bonds [Arabidopsis thaliana] |
| RefSeq | XP_002284489.1 | 0 | 1 | 283 | 1 | 284 | PREDICTED: hypothetical protein isoform 1 [Vitis vinifera] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3fcx_B | 0 | 4 | 281 | 2 | 280 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3fcx_A | 0 | 4 | 281 | 2 | 280 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3s8y_A | 0 | 5 | 277 | 4 | 274 | A Chain A, Bromide Soaked Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_B | 0 | 5 | 277 | 4 | 274 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_A | 0 | 5 | 277 | 4 | 274 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| formaldehyde oxidation II (glutathione-dependent) | S-FORMYLGLUTATHIONE-HYDROLASE-RXN | EC-3.1.2.12 | S-formylglutathione hydrolase |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| CN826258 | 285 | 1 | 284 | 0 |
| EX102539 | 251 | 1 | 251 | 0 |
| EW714403 | 259 | 1 | 259 | 0 |
| EE438421 | 270 | 1 | 269 | 0 |
| DT549152 | 283 | 1 | 282 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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