y
Basic Information | |
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Species | Brassica rapa |
Cazyme ID | Bra009310 |
Family | GH79 |
Protein Properties | Length: 471 Molecular Weight: 52738.8 Isoelectric Point: 9.004 |
Chromosome | Chromosome/Scaffold: 10 Start: 16107763 End: 16118113 |
Description | glucuronidase 2 |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 44 | 417 | 0 |
DENFVCATLDWWPHDKCNYDNCPWGYSSVINMDLSRPLLTKAIQAFKPLRIRIGGSLQDQVIYDVGNLQTPCHPFRKMNSGLFGFSKGCLHMKRWDELHN FLTKSGAIVTFGLNALHGRHKLRGNAWGGAWNHVNTQDFINYTVSNGYVIDSWEFGNELSGTGVGASVSAELYGKDVIVLRDIIDKMYKDSKLTKPLLVA PGGFYEQQWYTKLLEISGQDVVDVVTHHIYNLGSGNDPQLVKKILDPSYLSRIAETFKNVNKTIQEHGPWASPWVGESGGAYNSGGRRVSDTFIDSFWYL DQLGMSSKHNTKVYCRQTLVGGFYGLLEKGTFVPNPDYYSALLWHRLMGKGVLSVQTDGPPQLRVYAHCSKGRY |
Full Sequence |
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Protein Sequence Length: 471 Download |
MGFKVCIFLL LLGCLLLVPE RTMARDMKRA SIVIQGASRI AETDENFVCA TLDWWPHDKC 60 NYDNCPWGYS SVINMDLSRP LLTKAIQAFK PLRIRIGGSL QDQVIYDVGN LQTPCHPFRK 120 MNSGLFGFSK GCLHMKRWDE LHNFLTKSGA IVTFGLNALH GRHKLRGNAW GGAWNHVNTQ 180 DFINYTVSNG YVIDSWEFGN ELSGTGVGAS VSAELYGKDV IVLRDIIDKM YKDSKLTKPL 240 LVAPGGFYEQ QWYTKLLEIS GQDVVDVVTH HIYNLGSGND PQLVKKILDP SYLSRIAETF 300 KNVNKTIQEH GPWASPWVGE SGGAYNSGGR RVSDTFIDSF WYLDQLGMSS KHNTKVYCRQ 360 TLVGGFYGLL EKGTFVPNPD YYSALLWHRL MGKGVLSVQT DGPPQLRVYA HCSKGRYKIC 420 SWLAIIFCAQ SLANMRNLEN DLKQISMAMM FAVMGLVTNY LGPNRPAAKK * 480 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03669 | UPF0139 | 8.0e-25 | 416 | 470 | 55 | + Uncharacterized protein family (UPF0139). | ||
pfam03662 | Glyco_hydro_79n | 0 | 27 | 347 | 321 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
DDBJ | BAB08480.1 | 0 | 27 | 419 | 1 | 392 | unnamed protein product [Arabidopsis thaliana] |
EMBL | CAB62595.1 | 0 | 23 | 416 | 1 | 394 | putative protein [Arabidopsis thaliana] |
RefSeq | NP_196400.2 | 0 | 1 | 416 | 1 | 416 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
RefSeq | NP_200933.2 | 0 | 1 | 419 | 1 | 415 | AtGUS1 (Arabidopsis thaliana glucuronidase 1); beta-glucuronidase |
RefSeq | XP_002514696.1 | 0 | 23 | 453 | 18 | 440 | Heparanase-2, putative [Ricinus communis] |