| Basic Information | |
|---|---|
| Species | Brassica rapa |
| Cazyme ID | Bra012974 |
| Family | GH79 |
| Protein Properties | Length: 542 Molecular Weight: 60243.8 Isoelectric Point: 6.668 |
| Chromosome | Chromosome/Scaffold: 03 Start: 21242137 End: 21244692 |
| Description | glucuronidase 1 |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 42 | 535 | 0 |
| DENFVCATLDWWPPEKCNYDQCPWGYASLINLNLSSPLLAKAIQAFKTLRIRIGGSLQDQVIYDVGDLKTPCTQFKKTDDGLFGFSEGCLYMERWDELNR FFHATGAIVTFGLNALYGREKLRGNAWGGEWDHTNTQDFMNYTVSKGYAVDSWEFGNELSGSGIGASVSVELYGNDLIVLKDVIKNVYKTSQTKPLLLAP GGFYEEKWYSELFRLSGPGVLDVMTHHIYNLGPGNDPKLVSRILDPKYLSGSVTGLFKNVERTIQEHGPWASAWVGEAGGAFNSGGREVSETFINSFWYL DQFGMSSMHNTKVYCRQALVGGFYGLLEKETFVPNPDYYSALLWHRLMGKGVLGVQTNASEYLRTYVHCSKGRAGITILLINLSKQTTFTVGVSNGVKVV LQAESTKRRSFLETIKSKVSWVGKKASDGYLNREEYHLSPKDGDLRSKIMMLNGDPLEPTVTGDIPKLEPVRHGVKSPVYINPLSISFIVLPTF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 542 Download |
| MSYNVCFLVF LSCLLLPGVT FATNMEQTTI VIDGTRQIAE IDENFVCATL DWWPPEKCNY 60 DQCPWGYASL INLNLSSPLL AKAIQAFKTL RIRIGGSLQD QVIYDVGDLK TPCTQFKKTD 120 DGLFGFSEGC LYMERWDELN RFFHATGAIV TFGLNALYGR EKLRGNAWGG EWDHTNTQDF 180 MNYTVSKGYA VDSWEFGNEL SGSGIGASVS VELYGNDLIV LKDVIKNVYK TSQTKPLLLA 240 PGGFYEEKWY SELFRLSGPG VLDVMTHHIY NLGPGNDPKL VSRILDPKYL SGSVTGLFKN 300 VERTIQEHGP WASAWVGEAG GAFNSGGREV SETFINSFWY LDQFGMSSMH NTKVYCRQAL 360 VGGFYGLLEK ETFVPNPDYY SALLWHRLMG KGVLGVQTNA SEYLRTYVHC SKGRAGITIL 420 LINLSKQTTF TVGVSNGVKV VLQAESTKRR SFLETIKSKV SWVGKKASDG YLNREEYHLS 480 PKDGDLRSKI MMLNGDPLEP TVTGDIPKLE PVRHGVKSPV YINPLSISFI VLPTFDAPAC 540 S* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 25 | 345 | 321 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| DDBJ | BAB08480.1 | 0 | 25 | 541 | 1 | 516 | unnamed protein product [Arabidopsis thaliana] |
| EMBL | CAB62595.1 | 0 | 21 | 541 | 1 | 521 | putative protein [Arabidopsis thaliana] |
| RefSeq | NP_196400.2 | 0 | 1 | 541 | 1 | 543 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
| RefSeq | NP_200933.2 | 0 | 1 | 541 | 1 | 539 | AtGUS1 (Arabidopsis thaliana glucuronidase 1); beta-glucuronidase |
| RefSeq | XP_002514696.1 | 0 | 19 | 541 | 16 | 539 | Heparanase-2, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0006 | 92 | 448 | 75 | 425 | A Chain A, Structure Of Dually Phosphorylated Erk2 Bound To The Pea-15 Death Effector Domain |
| PDB | 3vnz_A | 0.0006 | 92 | 448 | 75 | 425 | A Chain A, Structure Of Dually Phosphorylated Erk2 Bound To The Pea-15 Death Effector Domain |
| PDB | 3vny_A | 0.0006 | 92 | 448 | 75 | 425 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
