| Basic Information | |
|---|---|
| Species | Brassica rapa |
| Cazyme ID | Bra023429 |
| Family | GH89 |
| Protein Properties | Length: 834 Molecular Weight: 96059.6 Isoelectric Point: 6.6121 |
| Chromosome | Chromosome/Scaffold: 02 Start: 3337134 End: 3341179 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH89 | 121 | 829 | 0 |
| GPEIVIKGTTGVEIASGLHWYLKYKCNAHVSWDKTGGIQIASVPLPGHLPRLEYSKRILIRRPVPWNYYQNVVTSSYSYVWWGWERWEREIDWMALQGVN LPLAFTGQEAIWLKVFKRFNISKEDLDDYFGGPAFLAWARMGNLHAWGGPLSRNWLSDQLNLQKQILSRMLELGMTPVLPSFSGNVPSALRKIYPAANIT RLDDWNTVDGDSRWCCTYLLNPSDPLFIDIGEAFIKQQTEEYGEITNIYNCDTFNENTPPTSEPEYISSLGAAVYKAMSKGNKNAVWLMQGWLFSSDSEF WKPPQMKALLHSVPFGKMIVLDLFADVKPIWNTSAQFYGTPYIWCMLHNFGGNIEMYGNLDSISSGPVDARVSENSTMVGVGMCMEGIEHNPVVYELMSE MAFRDEKVDVQKWLKSYARRRYMKQNDKVDAAWEILYHTVYNCTDGVADHNTDFIVKLPDWDPSSSSLHGTDTYMISTDTYETKRRFLFEDNSSDLPKAH LWYSTKEVIKALRLFLEAGDDLFGSLTYRYDMVDLTRQVLSKLANKVYMDAVTAFVRKDIESLRRLSEKFLELIKDIDVLLASDDNFLLGTWVESAKKLA RNSDERKQYEWNARTQVTMWYDSKGVNQSMLHDYANKFWSGLLEDYYLPRATLYFDELLKSLEDEKKLEIERWRREWIIMSHKWQQSSSEVYPVKAKGDA LAISRHLLS | |||
| Full Sequence |
|---|
| Protein Sequence Length: 834 Download |
| MVITWLWHLH IYSYHRHSLV SDEHTIKLTM PPIKFALLVL LILSIHSQSL SLQHPAINPL 60 LHRLDSLRPT SSVQESAAKG LLQRLIPTHS HSFEFSIISK DVCGGSSCFI IENHDGPRGN 120 GPEIVIKGTT GVEIASGLHW YLKYKCNAHV SWDKTGGIQI ASVPLPGHLP RLEYSKRILI 180 RRPVPWNYYQ NVVTSSYSYV WWGWERWERE IDWMALQGVN LPLAFTGQEA IWLKVFKRFN 240 ISKEDLDDYF GGPAFLAWAR MGNLHAWGGP LSRNWLSDQL NLQKQILSRM LELGMTPVLP 300 SFSGNVPSAL RKIYPAANIT RLDDWNTVDG DSRWCCTYLL NPSDPLFIDI GEAFIKQQTE 360 EYGEITNIYN CDTFNENTPP TSEPEYISSL GAAVYKAMSK GNKNAVWLMQ GWLFSSDSEF 420 WKPPQMKALL HSVPFGKMIV LDLFADVKPI WNTSAQFYGT PYIWCMLHNF GGNIEMYGNL 480 DSISSGPVDA RVSENSTMVG VGMCMEGIEH NPVVYELMSE MAFRDEKVDV QKWLKSYARR 540 RYMKQNDKVD AAWEILYHTV YNCTDGVADH NTDFIVKLPD WDPSSSSLHG TDTYMISTDT 600 YETKRRFLFE DNSSDLPKAH LWYSTKEVIK ALRLFLEAGD DLFGSLTYRY DMVDLTRQVL 660 SKLANKVYMD AVTAFVRKDI ESLRRLSEKF LELIKDIDVL LASDDNFLLG TWVESAKKLA 720 RNSDERKQYE WNARTQVTMW YDSKGVNQSM LHDYANKFWS GLLEDYYLPR ATLYFDELLK 780 SLEDEKKLEI ERWRREWIIM SHKWQQSSSE VYPVKAKGDA LAISRHLLSK YFT* 840 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 2.0e-25 | 74 | 172 | 99 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 3.0e-100 | 532 | 831 | 300 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 188 | 527 | 340 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 16 | 832 | 51 | 867 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC75285.1 | 0 | 74 | 832 | 56 | 811 | hypothetical protein OsI_11626 [Oryza sativa Indica Group] |
| RefSeq | NP_196873.1 | 0 | 30 | 832 | 1 | 805 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
| RefSeq | XP_002273084.1 | 0 | 34 | 833 | 3 | 803 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 49 | 832 | 20 | 805 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 79 | 822 | 175 | 867 | A Chain A, Crystal Structure At 1.45- Resolution Of The Major Allergen Endo-Beta-1,3-Glucanase Of Banana As A Molecular Basis For The Latex-Fruit Syndrome |
| PDB | 2vcb_A | 0 | 79 | 822 | 175 | 867 | A Chain A, Crystal Structure At 1.45- Resolution Of The Major Allergen Endo-Beta-1,3-Glucanase Of Banana As A Molecular Basis For The Latex-Fruit Syndrome |
| PDB | 2vca_A | 0 | 79 | 822 | 175 | 867 | A Chain A, Crystal Structure At 1.45- Resolution Of The Major Allergen Endo-Beta-1,3-Glucanase Of Banana As A Molecular Basis For The Latex-Fruit Syndrome |
| PDB | 2vc9_A | 0 | 79 | 822 | 175 | 867 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 79 | 822 | 198 | 890 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| Hydropathy |
|---|
 |
| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| HO783455 | 321 | 333 | 653 | 0 |
| HO783455 | 145 | 662 | 806 | 0 |
| GT627657 | 271 | 235 | 505 | 0 |
| GT622356 | 273 | 308 | 580 | 0 |
| DK464069 | 163 | 267 | 429 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
|---|
 |
