| Basic Information | |
|---|---|
| Species | Brassica rapa |
| Cazyme ID | Bra033670 |
| Family | CBM57 |
| Protein Properties | Length: 1016 Molecular Weight: 112102 Isoelectric Point: 7.8041 |
| Chromosome | Chromosome/Scaffold: 06 Start: 25712861 End: 25718174 |
| Description | Leucine-rich repeat transmembrane protein kinase |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| CBM57 | 424 | 579 | 1.3e-26 |
| SINCGGPEMRSNGEVFEKEDEDLGTASFFVSDVQRWAVSSVGYYSARRNNVWIINTLNAELYKSARHSSSSLRYYGLGLENGGYTVTLQFAEIIITDSYS WKGLGTRRFDIYIQGRLVEKDFDIRRTAGGNTIQAVQRKYKTNVSENYLEIHLFWA | |||
| Full Sequence |
|---|
| Protein Sequence Length: 1016 Download |
| MMPTCLLLIV WFLLCIPGSL HLVRAQNLTR AITDPDEAEA LNSIFAAWKI LRLREWNTSS 60 ELCSGNAIDD NIKIDDPAYN PFIKCDCTFN SSTICRITAL KVFGKDAVGP IPPQLWTLIY 120 LENLNLAQNY LTGSISPAIG NLTRMEWLTF GINALSGPFP KEIGLLTNLK SLGFGVNKFS 180 GSIPPEIGNC TKLMKIYLGN FELKGGLPSS FANLVKLEDL WIVDLDVTGR IPDFIGSWTK 240 LLTMRIHGTG WSGPIPSSFS NLTSLNELRL GDISNGSSSL DFIKDMKSLR ILVLRNNNLT 300 GTIPSDIGEF SNLEQVDLSF NQLHGPIPAS LFNLNQLTYL FLGNNTLNGS LPTQKSQGLS 360 DIDVSYNDLS GSLPPWVSLP NLKLNLVANN FTLKGHDKRI LQGLKCLQKN FPCNRGKGIY 420 SEFSINCGGP EMRSNGEVFE KEDEDLGTAS FFVSDVQRWA VSSVGYYSAR RNNVWIINTL 480 NAELYKSARH SSSSLRYYGL GLENGGYTVT LQFAEIIITD SYSWKGLGTR RFDIYIQGRL 540 VEKDFDIRRT AGGNTIQAVQ RKYKTNVSEN YLEIHLFWAG KGTAGVPIMG TYGPLITSVS 600 AKPDFRPTVG NMPPSKEKYS TGTIVGVIVG LGLVSIIAGV AIFMIRKRNK RYTDDAELLS 660 MDIKPYTFSY SELKNATQDF NPSSKLGEGG FGSVYKGKLN DGREIAVKVL SVGSQHGKGQ 720 FVAEIVAISA VMHRNLVQLY GCCYEGDHRL LVYEYLPNGS LDQALFGGGK TLYLDWSTRF 780 EICMGVARGL AYLHEEASVR IVHRDVKAGN ILLDSSLVPK VSDFGLAKLY DDKKTHISTR 840 VAGTIGYLAP EYAMRGHLTE KADVYAFGIV ALELVSGRKN TDVNLDNEKK YLLQWAWNLH 900 QDGREAELID QELAEFNMEE VKRVIGIALL CTYSSHSLRP PMSRVVAMLS GDVEVSKITS 960 QLGYLTDWRF DESSSSSFSA FQTKDTGASG SFSTGFVTPK DGNFKQLGVK IKEGR* 1020 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam00069 | Pkinase | 1.0e-45 | 685 | 878 | 198 | + Protein kinase domain. | ||
| smart00221 | STYKc | 6.0e-46 | 684 | 876 | 199 | + Protein kinase; unclassified specificity. Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase. | ||
| pfam11721 | Malectin | 9.0e-47 | 423 | 596 | 176 | + Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan. | ||
| smart00219 | TyrKc | 5.0e-47 | 683 | 876 | 200 | + Tyrosine kinase, catalytic domain. Phosphotransferases. Tyrosine-specific kinase subfamily. | ||
| cd00180 | PKc | 3.0e-48 | 686 | 874 | 193 | + Catalytic domain of Protein Kinases. Protein Kinases (PKs), catalytic (c) domain. PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase. PKs make up a large family of serine/threonine kinases, protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation, about 95%, occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and 550 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004672 | protein kinase activity |
| GO:0005515 | protein binding |
| GO:0005524 | ATP binding |
| GO:0006468 | protein phosphorylation |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | AAG50909.1 | 0 | 5 | 1015 | 1025 | 2062 | AC069159_10 receptor protein kinase, putative [Arabidopsis thaliana] |
| Swiss-Prot | C0LGH3 | 0 | 5 | 1015 | 9 | 1033 | Y5614_ARATH RecName: Full=Probable LRR receptor-like serine/threonine-protein kinase At1g56140; Flags: Precursor |
| RefSeq | NP_176008.4 | 0 | 22 | 1015 | 1 | 1047 | kinase [Arabidopsis thaliana] |
| RefSeq | NP_176009.1 | 0 | 3 | 1015 | 8 | 1032 | leucine-rich repeat family protein / protein kinase family protein [Arabidopsis thaliana] |
| RefSeq | NP_564709.1 | 0 | 5 | 1015 | 9 | 1032 | leucine-rich repeat family protein / protein kinase family protein [Arabidopsis thaliana] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3ulz_A | 0 | 668 | 952 | 20 | 309 | B Chain B, Structural Basis Of Gibberellin(Ga3)-Induced Della Recognition By The Gibberellin Receptor |
| PDB | 3uim_A | 0 | 668 | 952 | 20 | 309 | A Chain A, Structural Basis For The Impact Of Phosphorylation On Plant Receptor- Like Kinase Bak1 Activation |
| PDB | 3tl8_H | 0 | 668 | 952 | 28 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
| PDB | 3tl8_G | 0 | 668 | 952 | 28 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
| PDB | 3tl8_D | 0 | 668 | 952 | 28 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
