y
Basic Information | |
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Species | Brachypodium distachyon |
Cazyme ID | Bradi1g31250.1 |
Family | AA3 |
Protein Properties | Length: 588 Molecular Weight: 62186.8 Isoelectric Point: 9.2567 |
Chromosome | Chromosome/Scaffold: 1 Start: 26722143 End: 26725633 |
Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
AA3 | 46 | 583 | 0 |
EEQEEYDYIVVGGGAAGCPLAATLAGPGGGRVLLLERGGAPSEFPALATAGGFVRTLALADPSPESDAPAQAFSSEDGVANVRARVLGGGTAINAGFYSR AHPSWFQGQGETQGAEVTDWDMRLVNASYEWVEQELAFQPEVHGWQAAVRAALLEANVTPWNGFTVEHVTGTKIGATTFDASGRRHSAADLLAFARPGRL HVAIRATVTRIIINPIDPAARRGRSRPAVAAVGVVYQDRLLQQHHALLRPGGEVILSAGALGSPQLLLLSGIGPASDLTSLGIPNSADAPDVGKHMFDNP RNGISIIPSVPIDHSLIQVVGIPSANGTASYLEAASYIVPLAPMLRPAGPFISPSSPLYVTMATIMEKVPGPLSEGSLWLSSPNPLETPAVRFNYFSRPE DLAQCVVGVRRVAQVLRSRTMDIFRSTVGSSSQGRRGPVRRDFRIVGATLPVDWSTNNTAVADFCRRTVTTLWHYHGGCVVGKVVDRDFRVIGTRALRVV DGSTFSVTPGTNPQATVMMMGRYVGQKMVGERHSRRQA |
Full Sequence |
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Protein Sequence Length: 588 Download |
MAAAPARLRF FLLLVALLPS LAAAQSRPFG GAPPGYARYV ADAAGEEQEE YDYIVVGGGA 60 AGCPLAATLA GPGGGRVLLL ERGGAPSEFP ALATAGGFVR TLALADPSPE SDAPAQAFSS 120 EDGVANVRAR VLGGGTAINA GFYSRAHPSW FQGQGETQGA EVTDWDMRLV NASYEWVEQE 180 LAFQPEVHGW QAAVRAALLE ANVTPWNGFT VEHVTGTKIG ATTFDASGRR HSAADLLAFA 240 RPGRLHVAIR ATVTRIIINP IDPAARRGRS RPAVAAVGVV YQDRLLQQHH ALLRPGGEVI 300 LSAGALGSPQ LLLLSGIGPA SDLTSLGIPN SADAPDVGKH MFDNPRNGIS IIPSVPIDHS 360 LIQVVGIPSA NGTASYLEAA SYIVPLAPML RPAGPFISPS SPLYVTMATI MEKVPGPLSE 420 GSLWLSSPNP LETPAVRFNY FSRPEDLAQC VVGVRRVAQV LRSRTMDIFR STVGSSSQGR 480 RGPVRRDFRI VGATLPVDWS TNNTAVADFC RRTVTTLWHY HGGCVVGKVV DRDFRVIGTR 540 ALRVVDGSTF SVTPGTNPQA TVMMMGRYVG QKMVGERHSR RQANISS* 600 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
TIGR03970 | Rv0697 | 3.0e-22 | 127 | 566 | 476 | + dehydrogenase, Rv0697 family. This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function. | ||
pfam05199 | GMC_oxred_C | 3.0e-25 | 417 | 566 | 155 | + GMC oxidoreductase. This domain found associated with pfam00732. | ||
TIGR01810 | betA | 3.0e-27 | 128 | 577 | 507 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
COG2303 | BetA | 3.0e-30 | 128 | 582 | 508 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
PLN02785 | PLN02785 | 3.0e-148 | 102 | 580 | 511 | + Protein HOTHEAD |
Gene Ontology | |
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GO Term | Description |
GO:0009055 | electron carrier activity |
GO:0016491 | oxidoreductase activity |
GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
GO:0050660 | flavin adenine dinucleotide binding |
GO:0055114 | oxidation-reduction process |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ACN31582.1 | 0 | 1 | 581 | 1 | 586 | unknown [Zea mays] |
DDBJ | BAD37565.1 | 0 | 1 | 587 | 1 | 586 | putative (R)-(+)-mandelonitrile lyase isoform MDL3 precursor [Oryza sativa Japonica Group] |
GenBank | EAZ37866.1 | 0 | 159 | 587 | 60 | 485 | hypothetical protein OsJ_22211 [Oryza sativa Japonica Group] |
RefSeq | XP_002311915.1 | 0 | 34 | 577 | 2 | 517 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002437392.1 | 0 | 167 | 581 | 1 | 414 | hypothetical protein SORBIDRAFT_10g026110 [Sorghum bicolor] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 1ju2_B | 0 | 36 | 577 | 11 | 517 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
PDB | 1ju2_A | 0 | 36 | 577 | 11 | 517 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
PDB | 3gdp_B | 0 | 36 | 577 | 11 | 517 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
PDB | 3gdp_A | 0 | 36 | 577 | 11 | 517 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
PDB | 3gdn_B | 0 | 36 | 577 | 11 | 517 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
Metabolic Pathways | |||
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Pathway Name | Reaction | EC | Protein Name |
amygdalin and prunasin degradation | MANDELONITRILE-LYASE-RXN | EC-4.1.2.10 | (R)-mandelonitrile lyase |
vicianin bioactivation | MANDELONITRILE-LYASE-RXN | EC-4.1.2.10 | (R)-mandelonitrile lyase |