| Basic Information | |
|---|---|
| Species | Brachypodium distachyon |
| Cazyme ID | Bradi1g62007.1 |
| Family | GH89 |
| Protein Properties | Length: 810 Molecular Weight: 91591.3 Isoelectric Point: 7.489 |
| Chromosome | Chromosome/Scaffold: 1 Start: 61301294 End: 61318141 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 102 | 805 | 0 |
| AEIMIQGTTAVELASGLHWYLKYWCGVHISWDKTGGAQLASVPSPGSLPRVNGTGVKIKRPVPWNYYQNVVTSSYSFVWWDWRRWEKEIDWMALQGINLP LAFTGQEAVWQKVFKSFNVSDRDLDDFFGGPAFLAWARMGNLHAWGGPLSQNWLDGQLALQKKILSRMTELGMVPVLPSFSGNVPVAFKKLFPSANITRL GEWNTVDGDPRWCCTYILDPSDALFIDVGHAFIRQQIKEYGDITSIYNCDTFNENTPPTNEPAYISSLGSAIYEAMSSGNKDAVWLMQGWLFYSDAAFWK EPQMKALLHSVPIGKMIVLDLFADVKPVWKMSSQFYGVPYIWCMLHNFGGNIEMYGILDSISSGPIDARTSYGSTMVGVGMTMEGIEHNPVVFELMSEMS FRSQKVEVEDWLKSYSYRRYGQSNVKIEKAWGVLYHTIYNCTDGIADHNRDYIVEFPDMSPSSFSSHFSKQRGMPIVRKHPRFFLSEVSANLPHPHLWYS TNEAVKALELFLNAGNDLSKSLTFRYDLVDLTRQSLSKLANKVYLDAMDSYKNKNSSGLNFHTKKFLELIVDIDILLASDDNFLLGPWLESAKSLAMSEE ERKQYEWNARTQVTMWYDNTKTEQSHLHDYANKFWSGLLKNYYLPRASKYFTGLSRSLQENRSFQLEEWRRDWISYSNEWQSGEELYPVKAKGDALAISK SLFR | |||
| Full Sequence |
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| Protein Sequence Length: 810 Download |
| MRPPPPPSLA LLPFVLLLVL IPLPPAAATA AGHTWREALR TAAGRRAASP AVQEGAAAGV 60 LHRLLPSHAH SFRFQIDTKG GVCGESSCFR ISNVDGSGRG GAEIMIQGTT AVELASGLHW 120 YLKYWCGVHI SWDKTGGAQL ASVPSPGSLP RVNGTGVKIK RPVPWNYYQN VVTSSYSFVW 180 WDWRRWEKEI DWMALQGINL PLAFTGQEAV WQKVFKSFNV SDRDLDDFFG GPAFLAWARM 240 GNLHAWGGPL SQNWLDGQLA LQKKILSRMT ELGMVPVLPS FSGNVPVAFK KLFPSANITR 300 LGEWNTVDGD PRWCCTYILD PSDALFIDVG HAFIRQQIKE YGDITSIYNC DTFNENTPPT 360 NEPAYISSLG SAIYEAMSSG NKDAVWLMQG WLFYSDAAFW KEPQMKALLH SVPIGKMIVL 420 DLFADVKPVW KMSSQFYGVP YIWCMLHNFG GNIEMYGILD SISSGPIDAR TSYGSTMVGV 480 GMTMEGIEHN PVVFELMSEM SFRSQKVEVE DWLKSYSYRR YGQSNVKIEK AWGVLYHTIY 540 NCTDGIADHN RDYIVEFPDM SPSSFSSHFS KQRGMPIVRK HPRFFLSEVS ANLPHPHLWY 600 STNEAVKALE LFLNAGNDLS KSLTFRYDLV DLTRQSLSKL ANKVYLDAMD SYKNKNSSGL 660 NFHTKKFLEL IVDIDILLAS DDNFLLGPWL ESAKSLAMSE EERKQYEWNA RTQVTMWYDN 720 TKTEQSHLHD YANKFWSGLL KNYYLPRASK YFTGLSRSLQ ENRSFQLEEW RRDWISYSNE 780 WQSGEELYPV KAKGDALAIS KSLFRKYLS* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 3.0e-23 | 53 | 152 | 100 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 7.0e-98 | 511 | 807 | 297 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 167 | 506 | 340 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 7 | 809 | 62 | 868 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC75285.1 | 0 | 47 | 808 | 50 | 811 | hypothetical protein OsI_11626 [Oryza sativa Indica Group] |
| GenBank | EEE59081.1 | 0 | 47 | 809 | 50 | 812 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
| RefSeq | XP_002273084.1 | 0 | 17 | 809 | 8 | 803 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002465249.1 | 0 | 38 | 809 | 41 | 776 | hypothetical protein SORBIDRAFT_01g034960 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 97 | 798 | 207 | 867 | A Chain A, Characterization And Engineering Of The Bifunctional N- And O-glucosyltransferase Involved In Xenobiotic Metabolism In Plants |
| PDB | 2vcb_A | 0 | 97 | 798 | 207 | 867 | A Chain A, Characterization And Engineering Of The Bifunctional N- And O-glucosyltransferase Involved In Xenobiotic Metabolism In Plants |
| PDB | 2vca_A | 0 | 97 | 798 | 207 | 867 | A Chain A, Characterization And Engineering Of The Bifunctional N- And O-glucosyltransferase Involved In Xenobiotic Metabolism In Plants |
| PDB | 2vc9_A | 0 | 97 | 798 | 207 | 867 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 97 | 798 | 230 | 890 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
