| Basic Information | |
|---|---|
| Species | Brachypodium distachyon |
| Cazyme ID | Bradi3g54370.1 |
| Family | GH79 |
| Protein Properties | Length: 542 Molecular Weight: 58412.1 Isoelectric Point: 6.2969 |
| Chromosome | Chromosome/Scaffold: 3 Start: 54849942 End: 54853670 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 55 | 535 | 0 |
| QAFVCATLDWWPPEKCDYGTCAWGLASLLNLNLNNKILLNAVKAFSPLKLRLGGSLQDVLVYGTGDGPEPCTPFTFNSSVMFSFSQGCLPMHRWDELNAF FKKSGAQIIFGLNALNGRVPMPDGSLGGPWNYTNAASFIRYTVSKGYDIHGWELGNELSGSGVGARVGADQYAADVITLHQIIDKTYQGPKPLVIAPGGF FDAAWFNELVSKTKPNQMDVITHHIYNLGPGVDTHLIEKILDPSYLDGEASTFSNLQGILKSAGTSTVAWVGESGGAYNSGHHLVTDAFVFSFWYLDQLG MSAKYDTKSYCRQTLVGGNYGLLNTTTFEPNPDYYSALLWHRLMGTKVLSTTFNGTNKIRAYTHCARDTEGITLLLINLSGNDTNHIYVTSEGAHLYSAK KENRRFAHVPGLGEVAEFKRQEYHLTPKDGNLQSQHMLLNGNLLATDANGDIPKLEPVQVEGSQPITVGPYSIVFAHIPSF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 542 Download |
| MAAGLLLQVV GFCVWAVFSL GGSSATVSST SAAAAAAGGA LVVVDARSAI AETEQAFVCA 60 TLDWWPPEKC DYGTCAWGLA SLLNLNLNNK ILLNAVKAFS PLKLRLGGSL QDVLVYGTGD 120 GPEPCTPFTF NSSVMFSFSQ GCLPMHRWDE LNAFFKKSGA QIIFGLNALN GRVPMPDGSL 180 GGPWNYTNAA SFIRYTVSKG YDIHGWELGN ELSGSGVGAR VGADQYAADV ITLHQIIDKT 240 YQGPKPLVIA PGGFFDAAWF NELVSKTKPN QMDVITHHIY NLGPGVDTHL IEKILDPSYL 300 DGEASTFSNL QGILKSAGTS TVAWVGESGG AYNSGHHLVT DAFVFSFWYL DQLGMSAKYD 360 TKSYCRQTLV GGNYGLLNTT TFEPNPDYYS ALLWHRLMGT KVLSTTFNGT NKIRAYTHCA 420 RDTEGITLLL INLSGNDTNH IYVTSEGAHL YSAKKENRRF AHVPGLGEVA EFKRQEYHLT 480 PKDGNLQSQH MLLNGNLLAT DANGDIPKLE PVQVEGSQPI TVGPYSIVFA HIPSFYAPAC 540 M* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 45 | 354 | 312 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | EAY87898.1 | 0 | 1 | 540 | 1 | 540 | hypothetical protein OsI_09318 [Oryza sativa Indica Group] |
| GenBank | EAY99897.1 | 0 | 11 | 540 | 9 | 524 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
| GenBank | EAZ36024.1 | 0 | 11 | 540 | 9 | 524 | hypothetical protein OsJ_20330 [Oryza sativa Japonica Group] |
| RefSeq | NP_001048420.1 | 0 | 1 | 540 | 1 | 540 | Os02g0802200 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | XP_002452991.1 | 0 | 1 | 540 | 1 | 539 | hypothetical protein SORBIDRAFT_04g036200 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.000008 | 149 | 431 | 122 | 395 | A Chain A, Crystal Structure Of N-acetylglucosaminyltransferase I |
| PDB | 3vnz_A | 0.000008 | 149 | 431 | 122 | 395 | A Chain A, Crystal Structure Of N-acetylglucosaminyltransferase I |
| PDB | 3vny_A | 0.000008 | 149 | 431 | 122 | 395 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
