| Basic Information | |
|---|---|
| Species | Brachypodium distachyon |
| Cazyme ID | Bradi5g24207.1 |
| Family | GH89 |
| Protein Properties | Length: 830 Molecular Weight: 94405.3 Isoelectric Point: 5.2537 |
| Chromosome | Chromosome/Scaffold: 5 Start: 25919230 End: 25929170 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 100 | 805 | 0 |
| PEILILGVSGVEISAGLHWYLKHYCAAHISWAKTGGAQLSSVPHPGSLPHVPAGGILIRRPVDWSYYQNAVTSSYSFAWWDWERWENEIDWMALQGINLP LAFTGQEAIWQKVFQRYNISKSNLDDFFGGPAFLAWSRMANMHGWGGPLPQTWLDDQLTLQKKILSRMYAFGMSPVLPAFSGSIPAALKSKFPSAKVTHL GNWFTVDSNPRWCCTYLLDASDPLFVEIGKLFIEEQIREYGRTSHVYNCDTFDENTPPLSDPNYISSLGAATFRGMQSGDDDAIWLMQGWLFTYDPFWEP PQMKALLHSVPVGRMIVLDLYAEVKPVWINSDQFYGVPYIWCMLHNFAADFEMYGVLDAVASGPIDARLSENSTMVGVGMSMEGIEQNPIVYDLMSEMVF HHRQVDLQVWVETYPTRRYGKSIVELQDAWRILHQTLYNCTDGKNDKNRDVIVAFPDVEPFVIQTPGLHTSASKMFSTMSAKSYLVKDESNDAYEQPHLW YDTNVVIRALQLFLQYGDEVSDSSTFRYDLVDLTRQALAKYANQIFAKIIQSYKSNNMNQVTTLSECFLDLVNDLDMLLASHEGFLLGPWLESAKGLARD QEQEIQYEWNARTQITMWFDNTETKASLLRDYANKYWSGLLGDYYGPRAAIYFKYLILSLEKKEPFALEEWRREWISLTNNWQSDRKVFATAATGDALNI ARSLYM | |||
| Full Sequence |
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| Protein Sequence Length: 830 Download |
| MLPSSPAPRF LLLVAVIACA ASVTRCSGRR FAQLDRLREL HQRERRPPAE QVYAAEGLLA 60 RLLPSHSTSF EFRVISTEQC GGKACFIINN HPLFDGEGTP EILILGVSGV EISAGLHWYL 120 KHYCAAHISW AKTGGAQLSS VPHPGSLPHV PAGGILIRRP VDWSYYQNAV TSSYSFAWWD 180 WERWENEIDW MALQGINLPL AFTGQEAIWQ KVFQRYNISK SNLDDFFGGP AFLAWSRMAN 240 MHGWGGPLPQ TWLDDQLTLQ KKILSRMYAF GMSPVLPAFS GSIPAALKSK FPSAKVTHLG 300 NWFTVDSNPR WCCTYLLDAS DPLFVEIGKL FIEEQIREYG RTSHVYNCDT FDENTPPLSD 360 PNYISSLGAA TFRGMQSGDD DAIWLMQGWL FTYDPFWEPP QMKALLHSVP VGRMIVLDLY 420 AEVKPVWINS DQFYGVPYIW CMLHNFAADF EMYGVLDAVA SGPIDARLSE NSTMVGVGMS 480 MEGIEQNPIV YDLMSEMVFH HRQVDLQVWV ETYPTRRYGK SIVELQDAWR ILHQTLYNCT 540 DGKNDKNRDV IVAFPDVEPF VIQTPGLHTS ASKMFSTMSA KSYLVKDESN DAYEQPHLWY 600 DTNVVIRALQ LFLQYGDEVS DSSTFRYDLV DLTRQALAKY ANQIFAKIIQ SYKSNNMNQV 660 TTLSECFLDL VNDLDMLLAS HEGFLLGPWL ESAKGLARDQ EQEIQYEWNA RTQITMWFDN 720 TETKASLLRD YANKYWSGLL GDYYGPRAAI YFKYLILSLE KKEPFALEEW RREWISLTNN 780 WQSDRKVFAT AATGDALNIA RSLYMKYLRN ADSLQLEDMD GSFGKSTSL* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 7.0e-21 | 51 | 148 | 98 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 6.0e-98 | 509 | 807 | 299 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 165 | 503 | 339 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAE04506.2 | 0 | 19 | 819 | 18 | 818 | OSJNBb0059K02.16 [Oryza sativa (japonica cultivar-group)] |
| GenBank | EEC78143.1 | 0 | 19 | 819 | 18 | 818 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| GenBank | EEE61812.1 | 0 | 29 | 819 | 328 | 1118 | hypothetical protein OsJ_16433 [Oryza sativa Japonica Group] |
| RefSeq | XP_002280399.1 | 0 | 34 | 816 | 31 | 813 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002511461.1 | 0 | 6 | 813 | 6 | 805 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 70 | 828 | 192 | 891 | A Chain A, Crystal Structure Of Wild-Type E.Coli Gs In Complex With Adp And Glucose(Wtgsb) |
| PDB | 2vcb_A | 0 | 70 | 828 | 192 | 891 | A Chain A, Crystal Structure Of Wild-Type E.Coli Gs In Complex With Adp And Glucose(Wtgsb) |
| PDB | 2vca_A | 0 | 70 | 828 | 192 | 891 | A Chain A, Crystal Structure Of Wild-Type E.Coli Gs In Complex With Adp And Glucose(Wtgsb) |
| PDB | 2vc9_A | 0 | 70 | 828 | 192 | 891 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 70 | 828 | 215 | 914 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
