| Basic Information | |
|---|---|
| Species | Capsella rubella |
| Cazyme ID | Carubv10000251m |
| Family | GH89 |
| Protein Properties | Length: 807 Molecular Weight: 93550.3 Isoelectric Point: 8.9498 |
| Chromosome | Chromosome/Scaffold: 6 Start: 4406731 End: 4411443 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 93 | 801 | 0 |
| PEIVIKGTTGVEIASGLHWYLKYKCNAHVSWDKTGGIQIASVPQPGHLPRLDSKRILIRRPVPWNYYQNVVTSSYSYVWWGWERWQREIDWMALQGINLP LAFTGQEAIWQKVFKRFNISREDLDDYFGGPAFLAWARMGNLHAWGGPLSKNWLRDQLLLQKQILSQMLKLGMTPVLPSFSGNVPSALRKIYPGANITRL DNWNTVDGDSRWCCTYLLNPSDPLFIDIGEAFIKQQIEEYGEVTNIYNCDTFNENTPPTSEPGYISSLGAAVYKAMSKGNKNAVWLMQGWLFSSDSTFWK PPQMKALLHSVPFGKMIVLDLYAEVKPIWNTSIQFYRTPYIWCMLHNFGGNIEMYGVLDSISSGPVDARVSKNSTMVGVGMCMEGIEQNPVVYELTSEMA FRDEKVNVQKWLKSYARRRYMKENHQIEAAWEILYHTIYNCTDGIADHNTDFIVKLPDWDPSCSVQDESKETESYMTSTAPYETKRRFLFQDNISGFPKA HLWYSTKEVIKALKLFLEAGDDLSRSLTYRYDMVDLTRQVLSKLANQVYIEAVTAFVKKDIGRLRRLSEKFLEIMKDMDVLLASDNNFLLGTWLESAKKL ARNDDERKQYEWNARTQVTMWYDSKDVNQSKLHDYGNKFWSGLLEDYYLPRATLYFSEMIKSLRDKKKFKIEKWRREWIMKSHKWQQSSSEIYGVKAKGD ALAISRHLL | |||
| Full Sequence |
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| Protein Sequence Length: 807 Download |
| MRSIKLVLLV LWIFSLHSQS FSKQHPTIEN LLDRLDSLRP TRSVQESAAK GLLQRLLPAH 60 FHSFDFRIIS KNVCDGSSCF LIENYDGTRR FGPEIVIKGT TGVEIASGLH WYLKYKCNAH 120 VSWDKTGGIQ IASVPQPGHL PRLDSKRILI RRPVPWNYYQ NVVTSSYSYV WWGWERWQRE 180 IDWMALQGIN LPLAFTGQEA IWQKVFKRFN ISREDLDDYF GGPAFLAWAR MGNLHAWGGP 240 LSKNWLRDQL LLQKQILSQM LKLGMTPVLP SFSGNVPSAL RKIYPGANIT RLDNWNTVDG 300 DSRWCCTYLL NPSDPLFIDI GEAFIKQQIE EYGEVTNIYN CDTFNENTPP TSEPGYISSL 360 GAAVYKAMSK GNKNAVWLMQ GWLFSSDSTF WKPPQMKALL HSVPFGKMIV LDLYAEVKPI 420 WNTSIQFYRT PYIWCMLHNF GGNIEMYGVL DSISSGPVDA RVSKNSTMVG VGMCMEGIEQ 480 NPVVYELTSE MAFRDEKVNV QKWLKSYARR RYMKENHQIE AAWEILYHTI YNCTDGIADH 540 NTDFIVKLPD WDPSCSVQDE SKETESYMTS TAPYETKRRF LFQDNISGFP KAHLWYSTKE 600 VIKALKLFLE AGDDLSRSLT YRYDMVDLTR QVLSKLANQV YIEAVTAFVK KDIGRLRRLS 660 EKFLEIMKDM DVLLASDNNF LLGTWLESAK KLARNDDERK QYEWNARTQV TMWYDSKDVN 720 QSKLHDYGNK FWSGLLEDYY LPRATLYFSE MIKSLRDKKK FKIEKWRREW IMKSHKWQQS 780 SSEIYGVKAK GDALAISRHL LCKYFP* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 2.0e-24 | 45 | 143 | 99 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 6.0e-106 | 502 | 804 | 303 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 158 | 497 | 340 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 5 | 805 | 68 | 867 | unnamed protein product [Vitis vinifera] |
| GenBank | EEE59081.1 | 0 | 45 | 805 | 56 | 811 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
| RefSeq | NP_196873.1 | 0 | 1 | 806 | 1 | 806 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
| RefSeq | XP_002273084.1 | 0 | 5 | 805 | 3 | 802 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 27 | 805 | 28 | 805 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 50 | 743 | 175 | 816 | A Chain A, Solution Structure Of The C-Terminal Domain Ole E 9 |
| PDB | 2vcb_A | 0 | 50 | 743 | 175 | 816 | A Chain A, Solution Structure Of The C-Terminal Domain Ole E 9 |
| PDB | 2vca_A | 0 | 50 | 743 | 175 | 816 | A Chain A, Solution Structure Of The C-Terminal Domain Ole E 9 |
| PDB | 2vc9_A | 0 | 50 | 743 | 175 | 816 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 50 | 743 | 198 | 839 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
