| Basic Information | |
|---|---|
| Species | Capsella rubella |
| Cazyme ID | Carubv10004208m |
| Family | AA3 |
| Protein Properties | Length: 762 Molecular Weight: 83696.7 Isoelectric Point: 7.6685 |
| Chromosome | Chromosome/Scaffold: 7 Start: 8264856 End: 8269165 |
| Description | Long-chain fatty alcohol dehydrogenase family protein |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| AA3 | 230 | 746 | 0 |
| TGRGFTVSSQKNKSKGSSLSNPVMTIRCDAVVVGSGSGGGVVAGVLAKAGYKVLVVESGNYYARSNLSLLEGQAMEDMYLSGGLLATSDTNVVILAGSTV GGGSTINWSASIKTPEHVMKEWTEKSKLEMFGSDLYREAMDVVCERMGVQCGFVEEGFNNEILRKGCEELGLPVKNIPRNAPSDHYCGHCCLGCKKGQKQ GTSETWLVDLVQSGNGLILPGCKAMEVLYECEQGKKNKKKATGVAFAFGEEIYVVESRATVVACGALRTPHLLKRSGLKNGNIGRNLCLHPVVMAWGWFP EGEKWPEKKKMSYEGGIMTAMSSVVNAETQSSYGETVIQTPALHPGMFSGVTPWASSKDFKTRMLKFSRTAHIFALLRDKGTGTINSKSYIDYNLNDEDE ESLKKGLEEVLKIMAAAGAEEIGTHNSEGKSLNVRRASAVEFERFVREESSKPLKNLSGQICSAHQMGSCRMGIRPEESAVRPTGETWEVEGLFVADTSV FPTALGVNPMVTVQSIA | |||
| Full Sequence |
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| Protein Sequence Length: 762 Download |
| MSESKSDVEI GNLRRQTNET KPFYANSLTQ REMETLVAFC DTLIPSIDGS GVGGHVDDSV 60 AEYFAASASQ TGTPDRVARL MSERLDHPKK WILRVALWLL STWIGSLVLC GRRSFTGEFP 120 YFRRFCRLPT KQREAILLNW SESYFSLLRM FFRCIKLITA FVFFTQVDEK GRNLAWKAIG 180 YNGPSLDDSD HDLEEELNEK KKKPEEIFGP LYNGIVDLNC PREAVTKKLT GRGFTVSSQK 240 NKSKGSSLSN PVMTIRCDAV VVGSGSGGGV VAGVLAKAGY KVLVVESGNY YARSNLSLLE 300 GQAMEDMYLS GGLLATSDTN VVILAGSTVG GGSTINWSAS IKTPEHVMKE WTEKSKLEMF 360 GSDLYREAMD VVCERMGVQC GFVEEGFNNE ILRKGCEELG LPVKNIPRNA PSDHYCGHCC 420 LGCKKGQKQG TSETWLVDLV QSGNGLILPG CKAMEVLYEC EQGKKNKKKA TGVAFAFGEE 480 IYVVESRATV VACGALRTPH LLKRSGLKNG NIGRNLCLHP VVMAWGWFPE GEKWPEKKKM 540 SYEGGIMTAM SSVVNAETQS SYGETVIQTP ALHPGMFSGV TPWASSKDFK TRMLKFSRTA 600 HIFALLRDKG TGTINSKSYI DYNLNDEDEE SLKKGLEEVL KIMAAAGAEE IGTHNSEGKS 660 LNVRRASAVE FERFVREESS KPLKNLSGQI CSAHQMGSCR MGIRPEESAV RPTGETWEVE 720 GLFVADTSVF PTALGVNPMV TVQSIAYCIG LNVVDVLKRN N* 780 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| PRK02106 | PRK02106 | 0.0002 | 447 | 528 | 111 | + choline dehydrogenase; Validated | ||
| TIGR01810 | betA | 2.0e-5 | 468 | 731 | 302 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
| pfam05199 | GMC_oxred_C | 6.0e-23 | 607 | 749 | 150 | + GMC oxidoreductase. This domain found associated with pfam00732. | ||
| COG2303 | BetA | 8.0e-33 | 275 | 747 | 538 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
| pfam00732 | GMC_oxred_N | 5.0e-81 | 304 | 521 | 224 | + GMC oxidoreductase. This family of proteins bind FAD as a cofactor. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAA18625.1 | 4e-23 | 2 | 77 | 13 | 86 | putative protein [Arabidopsis thaliana] |
| EMBL | CAA18625.1 | 0 | 166 | 759 | 85 | 676 | putative protein [Arabidopsis thaliana] |
| RefSeq | NP_193673.2 | 0 | 33 | 759 | 1 | 724 | alcohol oxidase-related [Arabidopsis thaliana] |
| RefSeq | XP_002269629.1 | 0 | 21 | 759 | 28 | 785 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002328753.1 | 0 | 33 | 759 | 1 | 743 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3ljp_B | 0.00000007 | 426 | 745 | 205 | 518 | A Chain A, Crystal Structure Of Choline Oxidase V464a Mutant |
| PDB | 3ljp_A | 0.00000007 | 426 | 745 | 205 | 518 | A Chain A, Crystal Structure Of Choline Oxidase V464a Mutant |
| PDB | 2jbv_B | 0.0000001 | 426 | 745 | 205 | 518 | A Chain A, Crystal Structure Of Choline Oxidase Reveals Insights Into The Catalytic Mechanism |
| PDB | 2jbv_A | 0.0000001 | 426 | 745 | 205 | 518 | A Chain A, Crystal Structure Of Choline Oxidase Reveals Insights Into The Catalytic Mechanism |
| PDB | 3nne_H | 0.0000001 | 426 | 745 | 205 | 518 | A Chain A, Crystal Structure Of Choline Oxidase S101a Mutant |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| DC883850 | 463 | 304 | 759 | 0 |
| BX836801 | 309 | 398 | 706 | 0 |
| HO794753 | 763 | 11 | 757 | 0 |
| BX841281 | 297 | 63 | 359 | 0 |
| BX836801 | 51 | 707 | 757 | 1e-20 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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