| Basic Information | |
|---|---|
| Species | Capsella rubella |
| Cazyme ID | Carubv10004418m |
| Family | AA3 |
| Protein Properties | Length: 599 Molecular Weight: 64953.1 Isoelectric Point: 6.991 |
| Chromosome | Chromosome/Scaffold: 7 Start: 8267172 End: 8269165 |
| Description | Long-chain fatty alcohol dehydrogenase family protein |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| AA3 | 67 | 583 | 0 |
| TGRGFTVSSQKNKSKGSSLSNPVMTIRCDAVVVGSGSGGGVVAGVLAKAGYKVLVVESGNYYARSNLSLLEGQAMEDMYLSGGLLATSDTNVVILAGSTV GGGSTINWSASIKTPEHVMKEWTEKSKLEMFGSDLYREAMDVVCERMGVQCGFVEEGFNNEILRKGCEELGLPVKNIPRNAPSDHYCGHCCLGCKKGQKQ GTSETWLVDLVQSGNGLILPGCKAMEVLYECEQGKKNKKKATGVAFAFGEEIYVVESRATVVACGALRTPHLLKRSGLKNGNIGRNLCLHPVVMAWGWFP EGEKWPEKKKMSYEGGIMTAMSSVVNAETQSSYGETVIQTPALHPGMFSGVTPWASSKDFKTRMLKFSRTAHIFALLRDKGTGTINSKSYIDYNLNDEDE ESLKKGLEEVLKIMAAAGAEEIGTHNSEGKSLNVRRASAVEFERFVREESSKPLKNLSGQICSAHQMGSCRMGIRPEESAVRPTGETWEVEGLFVADTSV FPTALGVNPMVTVQSIA | |||
| Full Sequence |
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| Protein Sequence Length: 599 Download |
| MNSVDEKGRN LAWKAIGYNG PSLDDSDHDL EEELNEKKKK PEEIFGPLYN GIVDLNCPRE 60 AVTKKLTGRG FTVSSQKNKS KGSSLSNPVM TIRCDAVVVG SGSGGGVVAG VLAKAGYKVL 120 VVESGNYYAR SNLSLLEGQA MEDMYLSGGL LATSDTNVVI LAGSTVGGGS TINWSASIKT 180 PEHVMKEWTE KSKLEMFGSD LYREAMDVVC ERMGVQCGFV EEGFNNEILR KGCEELGLPV 240 KNIPRNAPSD HYCGHCCLGC KKGQKQGTSE TWLVDLVQSG NGLILPGCKA MEVLYECEQG 300 KKNKKKATGV AFAFGEEIYV VESRATVVAC GALRTPHLLK RSGLKNGNIG RNLCLHPVVM 360 AWGWFPEGEK WPEKKKMSYE GGIMTAMSSV VNAETQSSYG ETVIQTPALH PGMFSGVTPW 420 ASSKDFKTRM LKFSRTAHIF ALLRDKGTGT INSKSYIDYN LNDEDEESLK KGLEEVLKIM 480 AAAGAEEIGT HNSEGKSLNV RRASAVEFER FVREESSKPL KNLSGQICSA HQMGSCRMGI 540 RPEESAVRPT GETWEVEGLF VADTSVFPTA LGVNPMVTVQ SIAYCIGLNV VDVLKRNN* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| PRK02106 | PRK02106 | 0.0002 | 284 | 365 | 111 | + choline dehydrogenase; Validated | ||
| TIGR01810 | betA | 3.0e-5 | 305 | 568 | 302 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
| pfam05199 | GMC_oxred_C | 5.0e-23 | 444 | 586 | 150 | + GMC oxidoreductase. This domain found associated with pfam00732. | ||
| COG2303 | BetA | 2.0e-33 | 112 | 584 | 538 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
| pfam00732 | GMC_oxred_N | 3.0e-81 | 141 | 358 | 224 | + GMC oxidoreductase. This family of proteins bind FAD as a cofactor. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAA18625.1 | 0 | 2 | 596 | 84 | 676 | putative protein [Arabidopsis thaliana] |
| RefSeq | NP_193673.2 | 0 | 1 | 596 | 131 | 724 | alcohol oxidase-related [Arabidopsis thaliana] |
| RefSeq | XP_002269629.1 | 0 | 1 | 596 | 169 | 785 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002328753.1 | 0 | 1 | 596 | 137 | 743 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002519938.1 | 0 | 1 | 596 | 95 | 707 | electron carrier, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3ljp_B | 0.00000003 | 263 | 582 | 205 | 518 | A Chain A, Crystal Structure Of Choline Oxidase V464a Mutant |
| PDB | 3ljp_A | 0.00000003 | 263 | 582 | 205 | 518 | A Chain A, Crystal Structure Of Choline Oxidase V464a Mutant |
| PDB | 2jbv_B | 0.00000006 | 263 | 582 | 205 | 518 | A Chain A, Crystal Structure Of Choline Oxidase Reveals Insights Into The Catalytic Mechanism |
| PDB | 2jbv_A | 0.00000006 | 263 | 582 | 205 | 518 | A Chain A, Crystal Structure Of Choline Oxidase Reveals Insights Into The Catalytic Mechanism |
| PDB | 3nne_H | 0.00000006 | 263 | 582 | 205 | 518 | A Chain A, Crystal Structure Of Choline Oxidase S101a Mutant |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| DC883850 | 463 | 141 | 596 | 0 |
| BX836801 | 309 | 235 | 543 | 0 |
| HO794753 | 600 | 5 | 594 | 0 |
| EV019363 | 236 | 344 | 579 | 0 |
| BX836801 | 51 | 544 | 594 | 5e-21 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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