Basic Information | |
---|---|
Species | Capsella rubella |
Cazyme ID | Carubv10011709m |
Family | CBM57 |
Protein Properties | Length: 1007 Molecular Weight: 111896 Isoelectric Point: 7.3343 |
Chromosome | Chromosome/Scaffold: 1 Start: 10195586 End: 10207564 |
Description | Leucine-rich repeat transmembrane protein kinase |
View CDS |
External Links |
---|
CAZyDB |
Signature Domain Download full data set without filtering | |||
---|---|---|---|
Family | Start | End | Evalue |
CBM57 | 408 | 573 | 6.3e-27 |
HINCGGPDVTIENSRGRFLYEGDNYGLTSSSMSYHGKYWGFSNTGDFMDDGETDDTYSVTSESAVSAKYPELYHNARRSSLSLAYFGFCLENGSYNVKLH FAEIQFSDEEPFARLGKRFFNIYIQGKLIWEDFNIKEEANGTHKEVIREVNTTVSDNTLEIRFYWA |
Full Sequence |
---|
Protein Sequence Length: 1007 Download |
YKHMIMSQSR HLSSLLFVLT LIYLVYKTSA SPSLHPDEVK ALKDIALTLG VKHLNLSENP 60 CLTKTLVITQ DVLNGGKNST IICDCSFNNN STCHITHFIF KSSSLPGRLP PEFSKLRYLE 120 LIDLCRNYLY GSIPMEWASL PYLTSISVCA NRLSGDIPKG LGKFTNLTLL VLEANQFSGT 180 IPKELGNLVN LEGLALSSNQ LVGSVPKTLA RLRNLKNLRF SDNRLNGSIP EFIGNLSKLQ 240 RLELYASGLT EPIPESIFRL ENLKDLRISD TTAGLRQIPL ITSKRLETLV LRNMNLTGTI 300 PTSVWDLPKL KTLDLSFNSL TGEIPADASA PQYTYLAGNM LSGKVESGPF LTTSTNTDLS 360 YNNFTWSPSC IERNNVNTYE SSRSRNSLTR LLPCSAINQC KNYSRSLHIN CGGPDVTIEN 420 SRGRFLYEGD NYGLTSSSMS YHGKYWGFSN TGDFMDDGET DDTYSVTSES AVSAKYPELY 480 HNARRSSLSL AYFGFCLENG SYNVKLHFAE IQFSDEEPFA RLGKRFFNIY IQGKLIWEDF 540 NIKEEANGTH KEVIREVNTT VSDNTLEIRF YWAGKGTLII PKRGNYGSLI SAISVCPSSE 600 SECGVPRQIQ PVTKQHKPRR YPLILGIAAL ILSLAFLILG ALYWRICISN EDAGKRRGSF 660 SLRQLKVATD NFNPLNKIGE GGFGSVYKGR LPNGTLIAVK KLSSKSCQGN KEFINEIGII 720 TCLQHPNLVK LYGCCVDKTQ LLLVYEYLEN NCLADALFGR SSLKLDWQTR HKICLGIARG 780 LAFLHEDSAV KIIHRDIKGT NVLLDKDLNS KISDFGLARL HEDDQSHITT RVAGTIGYMA 840 PEYAMRGHLT EKADVYSFGV VAMEIVSGKS NANYTPDNEC CVGLLDWAFV LQKKGDFAEI 900 LDPRLAGMFD VLEAERMIKV SLLCSNKSPT LRPSMSEVVK MLEGETDIEQ IISDPGVYGE 960 DLRFNPSALP FDGIMSIPSS SESTYDHLMQ TNDLYPLSPE SIVFTS* |
Functional Domains Download unfiltered results here | ||||||||
---|---|---|---|---|---|---|---|---|
Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
smart00220 | S_TKc | 2.0e-50 | 672 | 870 | 201 | + Serine/Threonine protein kinases, catalytic domain. Phosphotransferases. Serine or threonine-specific kinase subfamily. | ||
cd00180 | PKc | 9.0e-51 | 678 | 865 | 192 | + Catalytic domain of Protein Kinases. Protein Kinases (PKs), catalytic (c) domain. PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase. PKs make up a large family of serine/threonine kinases, protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation, about 95%, occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and 550 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. | ||
smart00219 | TyrKc | 7.0e-53 | 675 | 942 | 283 | + Tyrosine kinase, catalytic domain. Phosphotransferases. Tyrosine-specific kinase subfamily. | ||
smart00221 | STYKc | 2.0e-53 | 675 | 942 | 283 | + Protein kinase; unclassified specificity. Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase. | ||
pfam11721 | Malectin | 2.0e-54 | 406 | 593 | 190 | + Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan. |
Gene Ontology | |
---|---|
GO Term | Description |
GO:0004672 | protein kinase activity |
GO:0005515 | protein binding |
GO:0005524 | ATP binding |
GO:0006468 | protein phosphorylation |
Annotations - NR Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAG10621.1 | 0 | 1 | 1005 | 5 | 945 | AC008030_21 Putative receptor-like serine/threonine kinase [Arabidopsis thaliana] |
GenBank | AAG50774.1 | 0 | 1 | 1002 | 5 | 968 | AC079288_3 receptor protein kinase, putative [Arabidopsis thaliana] |
GenBank | AAG50775.1 | 0 | 1 | 1005 | 5 | 938 | AC079288_4 receptor-like serine/threonine kinase, putative [Arabidopsis thaliana] |
RefSeq | NP_174266.2 | 0 | 1 | 1005 | 5 | 967 | ATP binding / kinase/ protein binding / protein kinase/ protein serine/threonine kinase/ protein tyrosine kinase [Arabidopsis thaliana] |
RefSeq | NP_174267.4 | 0 | 1 | 1002 | 5 | 1006 | kinase [Arabidopsis thaliana] |
Annotations - PDB Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3ulz_A | 0 | 660 | 945 | 20 | 309 | A Chain A, Human Gamma-Glutamyl Cyclotransferase |
PDB | 3uim_A | 0 | 660 | 945 | 20 | 309 | A Chain A, Structural Basis For The Impact Of Phosphorylation On Plant Receptor- Like Kinase Bak1 Activation |
PDB | 3tl8_H | 0 | 660 | 945 | 28 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
PDB | 3tl8_G | 0 | 660 | 945 | 28 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
PDB | 3tl8_D | 0 | 660 | 945 | 28 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |