| Basic Information | |
|---|---|
| Species | Capsella rubella |
| Cazyme ID | Carubv10020023m |
| Family | AA3 |
| Protein Properties | Length: 595 Molecular Weight: 65407.2 Isoelectric Point: 10.3591 |
| Chromosome | Chromosome/Scaffold: 2 Start: 11024255 End: 11027398 |
| Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| AA3 | 41 | 587 | 0 |
| EKASTFSSSSSSSFSSNGQDSSYDYIVIGGGTAGCPLAATLSQNFSVLVLERGGVPFTNANVSFLRNFHIGLADTSASSASQAFVSTDGVFNARARVLGG GSCINAGFYSRADDAFVKRSGWDPKLVKESYPWVERVIVHQPKLTLWQKALRDSLLEVGVRPFNGFTYDHVSGTKVGGTIFDRFGRRHTSAELLAYANPQ KLRVLIYATVQKIVFDTSGTRPRVTGVIFKDEKGNQHQALLSNRKGSEVILSSGAMGSPQMLMLSGIGPKKELQRLKIPVVLENEHVGKGMADNPMNTIL VPSKAPIEQSLIQTVGITKMGVYVEASTGFGQSPQSIHTHYGIMSDKNELFSATPAKQRRPEAAQAFIRRKKYQLHEAFNGSFILEKLAYPLSRGHLSLV NTNVDDNPSVTFNYFKHPADLQRCVEAIRLVSKVVTSKRFLNYTQCEKQDVHKMLSLSVKANINLRPKQLNDTESMAQFCKDTVVTIWHYHGGCLVGKVV SPNRRVLGVDRLRVIDGSTFHESPGTNPQATLMMMGRYMGVKILRKR | |||
| Full Sequence |
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| Protein Sequence Length: 595 Download |
| MALKLFLFAL LLCLPTSLSS TASKGKEKKL KFNPYRYSFI EKASTFSSSS SSSFSSNGQD 60 SSYDYIVIGG GTAGCPLAAT LSQNFSVLVL ERGGVPFTNA NVSFLRNFHI GLADTSASSA 120 SQAFVSTDGV FNARARVLGG GSCINAGFYS RADDAFVKRS GWDPKLVKES YPWVERVIVH 180 QPKLTLWQKA LRDSLLEVGV RPFNGFTYDH VSGTKVGGTI FDRFGRRHTS AELLAYANPQ 240 KLRVLIYATV QKIVFDTSGT RPRVTGVIFK DEKGNQHQAL LSNRKGSEVI LSSGAMGSPQ 300 MLMLSGIGPK KELQRLKIPV VLENEHVGKG MADNPMNTIL VPSKAPIEQS LIQTVGITKM 360 GVYVEASTGF GQSPQSIHTH YGIMSDKNEL FSATPAKQRR PEAAQAFIRR KKYQLHEAFN 420 GSFILEKLAY PLSRGHLSLV NTNVDDNPSV TFNYFKHPAD LQRCVEAIRL VSKVVTSKRF 480 LNYTQCEKQD VHKMLSLSVK ANINLRPKQL NDTESMAQFC KDTVVTIWHY HGGCLVGKVV 540 SPNRRVLGVD RLRVIDGSTF HESPGTNPQA TLMMMGRYMG VKILRKRLGD KAGV* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| TIGR03970 | Rv0697 | 1.0e-19 | 64 | 335 | 316 | + dehydrogenase, Rv0697 family. This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function. | ||
| pfam05199 | GMC_oxred_C | 2.0e-28 | 431 | 576 | 151 | + GMC oxidoreductase. This domain found associated with pfam00732. | ||
| TIGR01810 | betA | 9.0e-39 | 64 | 576 | 559 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
| COG2303 | BetA | 1.0e-47 | 63 | 585 | 574 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
| PLN02785 | PLN02785 | 0 | 63 | 594 | 532 | + Protein HOTHEAD | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| DDBJ | BAA77842.1 | 0 | 15 | 594 | 15 | 594 | ACE [Arabidopsis thaliana] |
| RefSeq | NP_001154469.1 | 0 | 15 | 594 | 15 | 567 | HTH (HOTHEAD); FAD binding / aldehyde-lyase/ mandelonitrile lyase [Arabidopsis thaliana] |
| RefSeq | NP_565050.1 | 0 | 15 | 594 | 15 | 594 | HTH (HOTHEAD); FAD binding / aldehyde-lyase/ mandelonitrile lyase [Arabidopsis thaliana] |
| RefSeq | XP_002329018.1 | 0 | 32 | 594 | 29 | 591 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002527404.1 | 0 | 34 | 593 | 38 | 596 | glucose-methanol-choline (gmc) oxidoreductase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3gdp_B | 0 | 60 | 587 | 24 | 517 | A Chain A, Glu381ser Mutant Of Maize Cytokinin OxidaseDEHYDROGENASE COMPLEXED With N6-Isopentenyladenosine |
| PDB | 3gdp_A | 0 | 60 | 587 | 24 | 517 | A Chain A, Glu381ser Mutant Of Maize Cytokinin OxidaseDEHYDROGENASE COMPLEXED With N6-Isopentenyladenosine |
| PDB | 3gdn_B | 0 | 60 | 587 | 24 | 517 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
| PDB | 3gdn_A | 0 | 60 | 587 | 24 | 517 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
| PDB | 3red_L | 0 | 60 | 587 | 24 | 518 | A Chain A, 3.0 A Structure Of The Prunus Mume Hydroxynitrile Lyase Isozyme-1 |
