Basic Information | |
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Species | Citrus clementina |
Cazyme ID | Ciclev10007919m |
Family | GH79 |
Protein Properties | Length: 548 Molecular Weight: 59980.1 Isoelectric Point: 8.1115 |
Chromosome | Chromosome/Scaffold: 1 Start: 26032709 End: 26035828 |
Description | glucuronidase 3 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 58 | 540 | 0 |
DDDFVCATLDWWPPEKCDYGTCSWDRASLLNLDLNSNILLNAVKAFSPLKIRLGGTLQDKVIYDTEDNRQPCKQFVKNSSEMFGFTQGCLPMHRWDELNA FFKKSGAKIVFGLNALTGRSIQNDGSVKGAWDYTNAESFISYTVKKNYSIHGWELGNELCGNGVGTRVAAAQYATDTISLRNVVQKIYTGVDSKPLIIAP GGFFDAKWFKEFLDKSGQSLDVATHHIYNLGPGVDQHLVEKILDPSYLDGEVDTFSQLENTLKSSATSAVAWVGESGGAYNSGHNLVTNAFVFSFWYLDQ LGMAAAHDTKTYCRQSLIGGNYGLLNTTTFVPNPDYYSALLWHRLMGRNALSTSFSGTKKIRSYAHCAKQSKGLVLLLINLDNSTTVHASVAFNGTLTSR HKHKSLKMKIIKLPQASVGGNEREEYHLTAKDGDLHSQTMLLNGNILSVNSIGDIPTLEPLRVKSTQPVSVGPFSIVFVHMPH |
Full Sequence |
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Protein Sequence Length: 548 Download |
MGSQAWLKVL LFGFCFWLSS RSSSSSSLSI LQAEAAGGAG FVGGNVFIDR RSVIGRTDDD 60 FVCATLDWWP PEKCDYGTCS WDRASLLNLD LNSNILLNAV KAFSPLKIRL GGTLQDKVIY 120 DTEDNRQPCK QFVKNSSEMF GFTQGCLPMH RWDELNAFFK KSGAKIVFGL NALTGRSIQN 180 DGSVKGAWDY TNAESFISYT VKKNYSIHGW ELGNELCGNG VGTRVAAAQY ATDTISLRNV 240 VQKIYTGVDS KPLIIAPGGF FDAKWFKEFL DKSGQSLDVA THHIYNLGPG VDQHLVEKIL 300 DPSYLDGEVD TFSQLENTLK SSATSAVAWV GESGGAYNSG HNLVTNAFVF SFWYLDQLGM 360 AAAHDTKTYC RQSLIGGNYG LLNTTTFVPN PDYYSALLWH RLMGRNALST SFSGTKKIRS 420 YAHCAKQSKG LVLLLINLDN STTVHASVAF NGTLTSRHKH KSLKMKIIKL PQASVGGNER 480 EEYHLTAKDG DLHSQTMLLN GNILSVNSIG DIPTLEPLRV KSTQPVSVGP FSIVFVHMPH 540 VILPACS* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 46 | 359 | 315 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CAN81917.1 | 0 | 1 | 546 | 1 | 554 | hypothetical protein [Vitis vinifera] |
EMBL | CBI25561.1 | 0 | 12 | 546 | 1 | 532 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002263173.1 | 0 | 1 | 546 | 5 | 558 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002324603.1 | 0 | 44 | 547 | 1 | 506 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002533671.1 | 0 | 7 | 546 | 3 | 550 | heparanase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.0000002 | 153 | 399 | 122 | 357 | A Chain A, Crystal Structure Of Human Beta-Galactosidase In Complex With Galactose |
PDB | 3vnz_A | 0.0000002 | 153 | 399 | 122 | 357 | A Chain A, Crystal Structure Of Human Beta-Galactosidase In Complex With Galactose |
PDB | 3vny_A | 0.0000002 | 153 | 399 | 122 | 357 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |