| Basic Information | |
|---|---|
| Species | Citrus clementina |
| Cazyme ID | Ciclev10010401m |
| Family | GH79 |
| Protein Properties | Length: 552 Molecular Weight: 60474.7 Isoelectric Point: 6.9025 |
| Chromosome | Chromosome/Scaffold: 1 Start: 1592275 End: 1594883 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
|---|
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 52 | 542 | 0 |
| DDNFICATLDWWPPDKCDYGTCSWGRASLLNLDLGNPILLKAVKAFSPLKIRMGGTLQDKAVYESKGIDEPCTPFVKNNSELFGFSEGCLTMRRWDELNI FFRRAGAVVTFGLNALRGRIIQSDGSARGAWDSSNAESLMRYTVNKGYKIYGWELGNELSGNGVGTRIGADQYASDVDRLQSIVQNIYKGFKIKPLIIAP GGFFDANWFKEFIDKTPESLQVVTHHIYNLGPGVDDRLIDKILDPSFLNSGSEPFSSLQSILRSSATSAVAWVGEAGGAYNSGHNLVTNAFVFSFWYLDQ LGMASIYGTKTYCRQTLIGGNYGLLNTNTFVPNPDYYSALLWHWLMGSNVLSTSLAGTTKIRAYAHCSKQSQGTTLLLINLDGNTTARVRVTISRENLAG NGALVVQQEQQNQRKRFAKICQDTKTNGKMREEYHLTARDGDLHSQTVLLNGEILAVNSSGDFPPLEPIYVSETAPIIVAPFSIVFAEIPS | |||
| Full Sequence |
|---|
| Protein Sequence Length: 552 Download |
| MCCVFILLFL CFWLFWAGHS SFIADSPSRT ASGSVIEGTV FINGTVAIAK TDDNFICATL 60 DWWPPDKCDY GTCSWGRASL LNLDLGNPIL LKAVKAFSPL KIRMGGTLQD KAVYESKGID 120 EPCTPFVKNN SELFGFSEGC LTMRRWDELN IFFRRAGAVV TFGLNALRGR IIQSDGSARG 180 AWDSSNAESL MRYTVNKGYK IYGWELGNEL SGNGVGTRIG ADQYASDVDR LQSIVQNIYK 240 GFKIKPLIIA PGGFFDANWF KEFIDKTPES LQVVTHHIYN LGPGVDDRLI DKILDPSFLN 300 SGSEPFSSLQ SILRSSATSA VAWVGEAGGA YNSGHNLVTN AFVFSFWYLD QLGMASIYGT 360 KTYCRQTLIG GNYGLLNTNT FVPNPDYYSA LLWHWLMGSN VLSTSLAGTT KIRAYAHCSK 420 QSQGTTLLLI NLDGNTTARV RVTISRENLA GNGALVVQQE QQNQRKRFAK ICQDTKTNGK 480 MREEYHLTAR DGDLHSQTVL LNGEILAVNS SGDFPPLEPI YVSETAPIIV APFSIVFAEI 540 PSSVLPACAQ G* |
| Functional Domains Download unfiltered results here | ||||||
|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description |
| pfam03662 | Glyco_hydro_79n | 0 | 37 | 353 | 318 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI25561.1 | 0 | 10 | 548 | 3 | 532 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002283254.1 | 0 | 1 | 550 | 1 | 538 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002283260.1 | 0 | 1 | 548 | 1 | 545 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002324878.1 | 0 | 38 | 548 | 1 | 504 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002515478.1 | 0 | 36 | 550 | 13 | 524 | heparanase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0002 | 140 | 445 | 115 | 409 | B Chain B, Reassembly And Co-Crystallization Of A Family 9 Processive Endoglucanase From Separately Expressed Gh9 And Cbm3c Modules |
| PDB | 3vnz_A | 0.0002 | 140 | 445 | 115 | 409 | B Chain B, Reassembly And Co-Crystallization Of A Family 9 Processive Endoglucanase From Separately Expressed Gh9 And Cbm3c Modules |
| PDB | 3vny_A | 0.0002 | 140 | 445 | 115 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
