| Basic Information | |
|---|---|
| Species | Citrus clementina |
| Cazyme ID | Ciclev10018883m |
| Family | GH89 |
| Protein Properties | Length: 815 Molecular Weight: 93088.8 Isoelectric Point: 5.5328 |
| Chromosome | Chromosome/Scaffold: 3 Start: 2719886 End: 2727822 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 102 | 803 | 0 |
| PEIVISGVTGVEVLAGLHWYLRYWCGSHISWDKTGGVQVASMPKLGSFPRVQDAGVFVKRPIPLNYYQNAVTSSYTFAWWDWKRWEKEIDWMALQGINLP LAFTGQETIWQKVFQKFNISNSDLDDFFGGPGFLAWSRMSNLHGWGGPLPQSWLDQQLVLQKKILVRMYELGMNPVLPAFSGNVPAALQNVFPSAKITQL GNWFSVKSDPRWCCTYLLDATDPLFIEIGRAFIEQQLKEYGRTSHIYNCDTFDENTPPVDSPEYISSLGAAIYSGMQSGDSDAVWLMQGWLFSYDPFWRP PQMKALLHSVPLGKLVVLDLFAEVKPIWSTSKQFYGVPYIWCMLHNFAGNIEMYGILDSIAFGPVEARTSENTTMVGVGMSMEGIEQNPVVYDLMSEMAF QHENVDVKAWINQYSVRRYGRSVPAIQDAWNVLYHTVYNCTDGATDKNRDVIVAFPDVDPSIISVTEGKYQNYGKPVSKKAVLKSETSSYDHPHLWYSTS EVIRALELFIASGNELSASNTYRYDLIDLTRQALAKYANELFLNILEAYQLNDAHGVFQLSRRFLELVEDMDGLLACHDGFLLGPWLESAKQLAQNEEQE KQYEWNARTQITMWFDNTQEEASLLRDYGNKYWSGLLRDYYGPRAAIYFKYMIESLESGDGFRLKDWRREWIKLTNYWQNGRNVYPVESNGDALITSQWL YN | |||
| Full Sequence |
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| Protein Sequence Length: 815 Download |
| MDSPFRSVSL ILFFITTITL STLAVAQSST IGVQYISRLL DIQDRERAPP SVQLAAAYAV 60 LQRLLPSHYS AFQFRIISKK QCGGEYCFIL RNHPSSYIRG TPEIVISGVT GVEVLAGLHW 120 YLRYWCGSHI SWDKTGGVQV ASMPKLGSFP RVQDAGVFVK RPIPLNYYQN AVTSSYTFAW 180 WDWKRWEKEI DWMALQGINL PLAFTGQETI WQKVFQKFNI SNSDLDDFFG GPGFLAWSRM 240 SNLHGWGGPL PQSWLDQQLV LQKKILVRMY ELGMNPVLPA FSGNVPAALQ NVFPSAKITQ 300 LGNWFSVKSD PRWCCTYLLD ATDPLFIEIG RAFIEQQLKE YGRTSHIYNC DTFDENTPPV 360 DSPEYISSLG AAIYSGMQSG DSDAVWLMQG WLFSYDPFWR PPQMKALLHS VPLGKLVVLD 420 LFAEVKPIWS TSKQFYGVPY IWCMLHNFAG NIEMYGILDS IAFGPVEART SENTTMVGVG 480 MSMEGIEQNP VVYDLMSEMA FQHENVDVKA WINQYSVRRY GRSVPAIQDA WNVLYHTVYN 540 CTDGATDKNR DVIVAFPDVD PSIISVTEGK YQNYGKPVSK KAVLKSETSS YDHPHLWYST 600 SEVIRALELF IASGNELSAS NTYRYDLIDL TRQALAKYAN ELFLNILEAY QLNDAHGVFQ 660 LSRRFLELVE DMDGLLACHD GFLLGPWLES AKQLAQNEEQ EKQYEWNART QITMWFDNTQ 720 EEASLLRDYG NKYWSGLLRD YYGPRAAIYF KYMIESLESG DGFRLKDWRR EWIKLTNYWQ 780 NGRNVYPVES NGDALITSQW LYNKYLQGTG VFDH* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 1.0e-19 | 53 | 144 | 92 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 7.0e-99 | 510 | 805 | 296 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 167 | 504 | 338 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI15090.1 | 0 | 1 | 813 | 1 | 845 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC78143.1 | 0 | 35 | 807 | 32 | 808 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| RefSeq | XP_002280399.1 | 0 | 1 | 813 | 1 | 812 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002318632.1 | 0 | 27 | 814 | 25 | 812 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511461.1 | 0 | 1 | 814 | 1 | 809 | alpha-n-acetylglucosaminidase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 100 | 795 | 210 | 866 | A Chain A, Crystal Structure Of Brassica Juncea Chitinase Catalytic Module (Bjchi3) |
| PDB | 2vcb_A | 0 | 100 | 795 | 210 | 866 | A Chain A, Crystal Structure Of Brassica Juncea Chitinase Catalytic Module (Bjchi3) |
| PDB | 2vca_A | 0 | 100 | 795 | 210 | 866 | A Chain A, Crystal Structure Of Brassica Juncea Chitinase Catalytic Module (Bjchi3) |
| PDB | 2vc9_A | 0 | 100 | 795 | 210 | 866 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 100 | 795 | 233 | 889 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
