Basic Information | |
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Species | Citrus clementina |
Cazyme ID | Ciclev10019304m |
Family | GH79 |
Protein Properties | Length: 629 Molecular Weight: 69858.7 Isoelectric Point: 8.5021 |
Chromosome | Chromosome/Scaffold: 3 Start: 7744611 End: 7750707 |
Description | glucuronidase 2 |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 125 | 621 | 0 |
DEHFICATVDWWPHDKCNYNHCPWGNSSVINLDLSHPLLANAIQAFQSLRIRIGGSLQDQVLYDVGDLKAPCHPFRKMKDGLFGFSKGCLHMQRWDELNQ LFNRTGAIVSFGLNALHGRHNIRHNAWGGAWDSNNARDFLKYTISMGYQIDSWEYGNELSGRTSIGASVDAELYGKDLINLKNIINELYKNSSSKPTILA PGGFFDQEWYAKFLQVSGSNVVNGVTHHIYNLGPGVDPNLVSKILNPQRLSRVSETFGNLKQTIEKHGPWASAWVGESGGAYNSGGRHVSNTFVNSFWYL DQLGMSSKYNTKVYCRQTLVGGNYGLLNATTFIPNPDYYSALLWHRLMGKGVLSVATDGSSSLRSYAHCSKEREGITLLLINLSNQTDYVISVHNSMNMK LTVKGKDINGESSLSRDIKRAVSWVGSTASDGHLTREEYHLTPKDGYLQSQTMVLNGIPLQLAEDEGIPKLDPVRVDVNSPIYITHLSIAFIVFPNF |
Full Sequence |
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Protein Sequence Length: 629 Download |
MGTFTLDRID TSSNPHSRKN LSLGGFLVQI YLTDPFQLTC CLFIVATTHK GPILRLLCLR 60 KLRVGLSALL LHSGSSCYLS SFFLAMGIFL SLFIYLISYL PVILARDVTR VTIFVDATKT 120 VATNDEHFIC ATVDWWPHDK CNYNHCPWGN SSVINLDLSH PLLANAIQAF QSLRIRIGGS 180 LQDQVLYDVG DLKAPCHPFR KMKDGLFGFS KGCLHMQRWD ELNQLFNRTG AIVSFGLNAL 240 HGRHNIRHNA WGGAWDSNNA RDFLKYTISM GYQIDSWEYG NELSGRTSIG ASVDAELYGK 300 DLINLKNIIN ELYKNSSSKP TILAPGGFFD QEWYAKFLQV SGSNVVNGVT HHIYNLGPGV 360 DPNLVSKILN PQRLSRVSET FGNLKQTIEK HGPWASAWVG ESGGAYNSGG RHVSNTFVNS 420 FWYLDQLGMS SKYNTKVYCR QTLVGGNYGL LNATTFIPNP DYYSALLWHR LMGKGVLSVA 480 TDGSSSLRSY AHCSKEREGI TLLLINLSNQ TDYVISVHNS MNMKLTVKGK DINGESSLSR 540 DIKRAVSWVG STASDGHLTR EEYHLTPKDG YLQSQTMVLN GIPLQLAEDE GIPKLDPVRV 600 DVNSPIYITH LSIAFIVFPN FSARACVV* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 110 | 428 | 319 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CAB62595.1 | 0 | 104 | 626 | 1 | 520 | putative protein [Arabidopsis thaliana] |
EMBL | CBI15157.1 | 0 | 100 | 627 | 14 | 513 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_002284470.1 | 0 | 100 | 627 | 14 | 539 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002321464.1 | 0 | 86 | 627 | 1 | 541 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002514696.1 | 0 | 101 | 627 | 15 | 539 | Heparanase-2, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.00007 | 175 | 516 | 75 | 409 | A Chain A, The Crystal Structure Of A Hyperthermoactive Exopolygalacturonase From Thermotoga Maritima |
PDB | 3vnz_A | 0.00007 | 175 | 516 | 75 | 409 | A Chain A, The Crystal Structure Of A Hyperthermoactive Exopolygalacturonase From Thermotoga Maritima |
PDB | 3vny_A | 0.00007 | 175 | 516 | 75 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |