Basic Information | |
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Species | Citrus clementina |
Cazyme ID | Ciclev10025289m |
Family | GT68 |
Protein Properties | Length: 564 Molecular Weight: 65073.2 Isoelectric Point: 7.2702 |
Chromosome | Chromosome/Scaffold: 7 Start: 7964711 End: 7967426 |
Description | O-fucosyltransferase family protein |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT68 | 244 | 538 | 0 |
NRVLVIPSSKFDYQYSRVLDIEHINDCLGRKVVVSFENFMEMKKNHAHIDRFLCYFGLPQPCFVDDEHIKKLKQLGISMGKTETVWKNEDTRKPSKRTVQ DIEGKFKTDDDVIAVGDLFYADVERDWVMQPGGPINHRCKTLIEPSRLIMVTAQRFVQTFLGSNFIALHFRRHGFLKFCNAKKPSCFYPIPQAADCITRL AERAKAPVIYLSTDAAESETSLLQSLVVLNGKTIALVKRPPRNSAEKWDSLLYRHHLEDDSQVEAMLDKTICAMSNVFIGASGSTFTEDIMRLRK |
Full Sequence |
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Protein Sequence Length: 564 Download |
MERDSSDDDD DRETLIHQND TKHGNHRLPT SDNNEDEEHN RRHSTFHIDD FPNAPPIRRR 60 FTFDFKKLNN KRYLFALSLP LLIILLYFSV NLRSLFSGNY VNFRFDSLAD RMRESELRAL 120 SLLKQQQSHL LSLWNQSFVN NSYGNNTNNP FFQEAKSVLL NQISLNRQIE QILLSPHKVS 180 NFTPNDAVWG LESCRKIDSI IPNKRTVEWK PKSDKFLFAI CLSGQMSNHL ICLEKHMFLA 240 ALLNRVLVIP SSKFDYQYSR VLDIEHINDC LGRKVVVSFE NFMEMKKNHA HIDRFLCYFG 300 LPQPCFVDDE HIKKLKQLGI SMGKTETVWK NEDTRKPSKR TVQDIEGKFK TDDDVIAVGD 360 LFYADVERDW VMQPGGPINH RCKTLIEPSR LIMVTAQRFV QTFLGSNFIA LHFRRHGFLK 420 FCNAKKPSCF YPIPQAADCI TRLAERAKAP VIYLSTDAAE SETSLLQSLV VLNGKTIALV 480 KRPPRNSAEK WDSLLYRHHL EDDSQVEAML DKTICAMSNV FIGASGSTFT EDIMRLRKDW 540 GSTSLCDEYL CQGEEPNFIA EDE* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam10250 | O-FucT | 0.0005 | 392 | 537 | 177 | + GDP-fucose protein O-fucosyltransferase. This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. | ||
cd11548 | NodZ_like | 0.0003 | 383 | 531 | 150 | + Alpha 1,6-fucosyltransferase similar to Bradyrhizobium NodZ. Bradyrhizobium NodZ is an alpha 1,6-fucosyltransferase involved in the biosynthesis of the nodulation factor, a lipo-chitooligosaccharide formed by three-to-six beta-1,4-linked N-acetyl-d-glucosamine (GlcNAc) residues and a fatty acid acyl group attached to the nitrogen atom at the non-reducing end. NodZ transfers L-fucose from the GDP-beta-L-fucose donor to the reducing residue of the chitin oligosaccharide backbone, before the attachment of a fatty acid group. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
cd11296 | O-FucT_like | 0.0001 | 216 | 250 | 35 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
cd11298 | O-FucT-2 | 5.0e-9 | 390 | 530 | 141 | + GDP-fucose protein O-fucosyltransferase 2. O-FucT-2 adds O-fucose to thrombospondin type 1 repeats (TSRs), and appears conserved in bilateria. The O-fucosylation of TSRs appears to play a role in regulating secretion of metalloproteases of the ADAMTS superfamily. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
cd11296 | O-FucT_like | 4.0e-18 | 379 | 537 | 169 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAM66093.1 | 0 | 1 | 563 | 1 | 566 | unknown [Arabidopsis thaliana] |
RefSeq | NP_173170.2 | 0 | 1 | 563 | 1 | 564 | unknown protein [Arabidopsis thaliana] |
RefSeq | NP_199853.1 | 0 | 1 | 563 | 1 | 566 | unknown protein [Arabidopsis thaliana] |
RefSeq | XP_002264087.1 | 0 | 1 | 563 | 1 | 559 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002533327.1 | 0 | 1 | 563 | 1 | 565 | conserved hypothetical protein [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 4ap6_D | 0.002 | 404 | 530 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
PDB | 4ap6_C | 0.002 | 404 | 530 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
PDB | 4ap6_B | 0.002 | 404 | 530 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
PDB | 4ap6_A | 0.002 | 404 | 530 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
PDB | 4ap5_B | 0.002 | 404 | 530 | 263 | 369 | A Chain A, Crystal Structure Of Human Pofut2 |